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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 4
Apr.  2014
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Article Contents

Research advances in osteopontin and liver diseases

DOI: 10.3969/j.issn.1001-5256.2014.04.024
  • Published Date: 2014-04-20
  • There has been rapid research progress in the biological characteristics and function of osteopontin (OPN) over the last 20 years.OPN, synthesized and secreted by many tissue cells, has a similar structure as many matrix proteins and possesses the functional characteristics of cytokines.It is involved in the physiological and pathological processes such as inflammation, wound healing, bone formation, and remodeling, as well as development of cancer and liver diseases.Recent studies on the biological characteristics of OPN and its role in hepatitis, liver fibrosis, and liver cancer are reviewed.These studies have shown that abnormal changes in OPN expression occur in many liver diseases and may play an important role in the development and progression of these diseases and that detecting or suppressing OPN expression is of clinical significance for preventing and treating hepatitis, liver fibrosis, and liver cancer.

     

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