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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 5
May  2014
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Article Contents

Significance of clinical pathology in diagnosis and treatment of autoimmune liver diseases

DOI: 10.3969/j.issn.1001-5256.2014.05.001
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  • Received Date: 2014-03-25
  • Published Date: 2014-05-20
  • Liver biopsy plays an important role in the diagnosis of autoimmune liver diseases, particularly in patients without specific clinical manifestations or negative for autoantibodies. The histological features of several autoimmune liver diseases are reviewed. The characteristic features of autoimmune hepatitis in histology include interface hepatitis with lymphoplasmacytic infiltration, hepatic rosette formation, and emperipolesis, while chronic nonsuppurative destructive cholangitis and epithelioid granuloma are frequently found in primary biliary cirrhosis. Primary sclerosing cholangitis is characterized by onion skin- like periductal fibrosis, while storiform fibrosis with IgG4- positive plasma cell infiltration often indicates IgG4- related sclerosing cholangitis. Enhanced communication between clinicians and pathologists can help improve the diagnosis and treatment of autoimmune liver diseoses.

     

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