IgG4- related diseases are a class of chronic, progressive, systemic inflammatory disorders that are characterized by lymphoplasmacytic inflammation, as well as elevated IgG4 levels in serum and tissue, and may involve multiple organs or tissues. When involving the pancreas, liver, and biliary tracts, they are called IgG4- related hepatobiliary diseases. IgG4- related autoimmune pancreatitis, IgG4- related sclerosing cholangitis, and IgG4- associated autoimmune hepatitis are reviewed in terms of their clinical manifestations and laboratory findings. Accurate identification of the laboratory results for IgG4- related hepatobiliary diseases and correct diagnosis of these diseases help to avoid unnecessary surgery and wrong treatment.
[1]KAMISAWA T, FUNATA N, HAYASHI Y, et al.A new clinicopathological entity of IgG4-related autoimmune disease[J].J Gastroenterol, 2003, 38 (10) :982-984.
|
[2]TAKAHASHI H, YAMAMOTO M, SUZUKI C, et al.The birthday of a new syndrome:IgG4-related diseases constitute a clinical entity[J].Autoimmun Rev, 2010, 9 (9) :591-594.
|
[3]HAMANO H, KAWA S, HORIUCHI A, et al.High serum IgG4concentrations in patients with sclerosing pancreatitis[J].N Engl J Med, 2001, 344 (10) :732-738.
|
[4]ZHANG L, SMYRK TC.Autoimmune pancreatitis and IgG4-related systemic diseases[J].Int J Clin Exp Pathol, 2010, 3 (5) :491-504.
|
[5]FRULLONI L, LUNARDI C, SIMONE R, et al.Identification of a novel antibody associated with autoimmune pancreatitis[J].N Engl J Med, 2009, 361 (22) :2135-2142.
|
[6]STONE JH, ZEN Y, DESHPANDE V.IgG4-Related Disease[J].N Engl J Med, 2012, 366 (6) :539-551.
|
[7]SAH RP, CHARI ST.Serologic issues in IgG4-related systemic disease and autoimmune pancreatitis[J].Curr Opin Rheumatol, 2011, 23 (1) :108-113.
|
[8]KAMISAWA T, SHIMOSEGAWA T, OKAZAKI K, et al.Standard steroid treatment for autoimmune pancreatitis[J].Gut, 2009, 58 (11) :1504-1507.
|
[9]SARLES H, SARLES JC, MURATORE R, et al.Chronic inflammatory sclerosis of the pancreas—an autonomous pancreatic disease?[J].Am J Dig Dis, 1961, 6 (7) :688-698.
|
[10]YOSHIDA K, TOKI F, TAKEUCHI T, et al.Chronic pancreatitis caused by an autoimmune abnormality.Proposal of the concept of autoimmune pancreatitis[J].Dig Dis Sci, 1995, 40 (7) :1561-1568.
|
[11]RYU JK, LEE JK, KIM YT, et al.Clinical features of chronic pancreatitis in Korea:a multicenter nationwide study[J].Digestion, 2005, 72 (4) :207-211.
|
[12]ZHANG L, CHARI S, SMYRK TC, et al.Autoimmune pancreatitis (AIP) type 1 and type 2:an international consensus study on histopathologic diagnostic criteria[J].Pancreas, 2011, 40 (8) :1172-1179.
|
[13]SAH RP, CHARI ST, PANNALA R, et al.Differences in clinical profile and relapse rate of type 1 versus type 2 autoimmune pancreatitis pancreatitis[J].Gastroenterology, 2010, 139 (1) :140-148.
|
[14]KAWA S, HAMANO H.Assessment of serological markers for the diagnosis of autoimmune pancreatitis[J].J Jpn Pancreas Soc, 2003, 17 (1) :607-610.
|
[15]KAMISAWA T, KIM MH, LIAO WC, et al.Clinical characteristics of 327 Asian patients with autoimmune pancreatitis based on Asian diagnostic criteria[J].Pancreas, 2011, 40 (2) :200-205.
|
[16]KAMISAWA T, CHARI ST, GIDAY SA, et al.Clinical profile of autoimmune pancreatitis and its histological subtypes:an international multicenter survey[J].Pancreas, 2011, 40 (6) :809-814.
|
[17]PAIK WH, RYU JK, PARK JM, et al.Clinical and pathological differences between serum immunoglobulin G4-positive and-negative type 1 autoimmune pancreatitis[J].World J Gastroenterol, 2013, 19 (25) :4031-4038.
|
[18]MATSUBAYASHI H, SAWAI H, KIMURA H, et al.Characteristics of autoimmune pancreatitis based on serum IgG4 level[J].Dig Liver Dis, 2011, 43 (9) :731-735.
|
[19]FRULLONI L, SCATTOLINI C, FALCONI M, et al.Autoimmune pancreatitis:differences between the focal and diffuse forms in 87patients[J].Am J Gastroenterol, 2009, 104 (9) :2288-2294.
|
[20]NAITOH I, NAKAZAWA T, OHARA H, et al.Clinical significance of extrapancreatic lesions in autoimmune pancreatitis[J].Pancreas, 2010, 39 (1) :e1-e5.
|
[21]SHIMOSEGAWA T, CHARI ST, FRULLONI L, et al.International consensus diagnostic criteria for autoimmune pancreatitis:guidelines of the International Association of Pancreatology[J].Pancreas, 2011, 40 (3) :352-358.
|
[22]OTSUKI M, CHUNG JB, OKAZAKI K, et al.Asian diagnostic criteria for autoimmune pancreatitis:consensus of the Japan-Korea Symposium on Autoimmune Pancreatitis[J].J Gastroenterol, 2008, 43 (6) :403-408.
|
[23]OKAZAKI K, TOMIYAMA T, MITSUYAMA T, et al.Diagnosis and classification of autoimmune pancreatitis[J].Autoimmun Rev, 2014, 13 (4-5) :451-458.
|
[24]CHARI ST, TAKAHASHI N, LEVY MJ, et al.A diagnostic strategy to distinguish autoimmune pancreatitis from pancreatic cancer[J].Clin Gastroenterol Hepatol, 2009, 7 (10) :1097-1103.
|
[25]PICKARTZ T, MAYERLE J, LERCH M.Autoimmune pancreatitis[J].Nat Clin Pract Gastroenterol Hepatol, 2007, 4 (6) :314-323.
|
[26]GHAZALE A, CHARI ST, ZHANG L, et al.Immunoglobulin G4-associated cholangitis:clinical profile and response to therapy[J].Gastroenterology, 2008, 134 (3) :706-715.
|
[27]NISHINO T, OYAMA H, HASHIMOTO E, et al.Clinicopathological differentiation between sclerosing cholangitis with autoimmune pancreatitis and primary sclerosing cholangitis[J].J Gastroenterol, 2007, 42 (7) :550-559.
|
[28]NAKAZAWA T, NAITOH I, HAYASHI K, et al.Diagnostic criteria for IgG4-related sclerosing cholangitis based on cholangiographic classification[J].J Gastroenterol, 2012, 47 (1) :79-87.
|
[29]OSEINI AM, CHAITEERAKIJ R, SHIRE AM, et al.Utility of serum immunoglobulin G4 in distinguishing immunoglobulin G4-associated cholangitis from cholangiocarcinoma[J].Hepatology, 2011, 54 (3) :940-948.
|
[30]MENDES FD, JORGENSEN R, KEACH J, et al.Elevated serum IgG4concentration in patients with primary sclerosing cholangitis[J].Am J Gastroenterol, 2006, 101 (9) :2070-2075.
|
[31]NAKAZAWA T, NAITOH I, HAYASHI K, et al.Diagnosis of IgG4-related sclerosing cholangitis[J].World J Gastroenterol, 2013, 19 (43) :7661-7670.
|
[32]HIRANO K, TADA M, ISAYAMA H, et al.Endoscopic evaluation of factors contributing to intrapancreatic biliary stricture in autoimmune pancreatitis[J].Gastrointest Endosc, 2010, 71 (1) :85-90.
|
[33]OHARA H, OKAZAKI K, TSUBOUCHI H, et al.Clinical diagnostic criteria of IgG4-related sclerosing cholangitis 2012[J].J Hepatobiliary Pancreat Sci, 2012, 19 (5) :536-542.
|
[34]NAITOH I, NAKAZAWA T, OHARA H, et al.Endoscopic transpapillary intraductal ultrasonography and biopsy in the diagnosis of IgG4-related sclerosing cholangitis[J].J Gastroenterol, 2009, 44 (11) :1147-1155.
|
[35]UMEMURA T, ZEN Y, HAMANO H, et al.Immunoglobin G4-hepatopathy:association of immunoglobin G4-bearing plasma cells in liver with autoimmune pancreatitis[J].Hepatology, 2007, 46 (2) :463-471.
|
[36]UMEMURA T, ZEN Y, HAMANO H, et al.Clinical significance of immunoglobulin G4-associated autoimmune hepatitis[J].J Gastroenterol, 2011, 46 (Suppl 1) :48-55.
|
[37]CHUNG H, WATANABE T, KUDO M, et al.Identification and characterization of IgG4-associated autoimmune hepatitis[J].Liver Int, 2010, 30 (2) :222-231.
|