Primary biliary cirrhosis ( PBC) is characterized by injury of small intrahepatic bile ducts, but its mechanism, especially the role of B cell immunity in this disease, remains unclear. The possible role of B cell immunity in the pathogenesis of PBC is reviewed from the following aspects: distribution of B cells and plasma cells in the liver tissues of PBC patients, clearance of B cells, mechanism of abnormal increase in serum IgM and its sources among PBC patients, mechanism of production of antimitochondrial antibodies and their possible functions in bile duct injury, and typical autoantibodies in PBC. B cell immunity is considered to play a significant role in the pathogenesis of PBC, but there are still many key problems to be clarified.
[1]BOGDANOS DP, KOMOROWSKI L.Disease-specific autoantibodies in primary biliary cirrhosis[J].Clin Chim Acta, 2011, 412 (7-8) :502-512.
|
[2]HIRSCHFIELD GM, GERSHWIN ME.Primary biliary cirrhosis:one disease with many faces[J].IMAJ, 2011, 13 (1) :55-59.
|
[3]YIN YF, ZHANG X.B cell depletion in treating primary biliary cirrhosis:pros and cons[J].World J Gastroenterol, 2012, 18 (30) :3938-3940.
|
[4]HU CJ, ZHANG FC, LI YZ, et al.Primary biliary cirrhosis:what do autoantibodies tell us?[J].World J Gastroenterol, 2010, 16 (29) :3616-3629.
|
[5]TAKAHASHI T, MIURA T, NAKAMURA J, et al.Plasma cells and the chronic nonsuppurative destructive cholangitis of primary billiary cirrhosis[J].Hepatology, 2012, 55 (3) :846-855.
|
[6]YOU Z, WANG Q, BIAN Z, et al.The immunopathology of liver granulomas in primary biliary cirrhosis[J].J Autoimmun, 2012, 39 (3) :216-221.
|
[7]RUBIO CA, TRUSKAITE K, RAJANI R, et al.A method to assess the distribution and frequency of plasma cells and plasma cell precursors inautoimmune hepatitis[J].Anticancer Res, 2013, 33 (2) :665-669.
|
[8]GMEZ-PUERTA JA, QUINTANA LF, STONE JH, et al.B-cell depleting agents for ANCA vasculitides:A new therapeutic approach[J].Autoimmun Rev, 2012, 11 (9) :646-652.
|
[9]AGARWAL SK.Biologic agents in rheumatoid arthritis:an update for managed care professionals[J].J Manag Care Pharm, 2011, 17:s14.
|
[10]DHIRAPONG A, LLEO A, YANG GX, et al.B cell depletion therapy exacerbates murine primary biliary cirrhosis[J].Hepatology, 2011, 53 (2) :527-535.
|
[11]MORITOKI Y, LIAN ZX, LINDOR K, et al.B-cell depletion with anti-CD20 ameliorates autoimmune cholangitis but exacerbates colitis in transforming growth factor-beta receptor II dominant negative mice[J].Hepatology, 2009, 50 (6) :1893-1903.
|
[12] TSUDA M, MORITOKI Y, LIAN ZX, et al.Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid[J].Hepatology, 2012, 55 (2) :512-521.
|
[13]MENNDEZ-CARO JL, ALVAREZ-MON M, GIRN JA, et al.Increased IgM B cell differentiation lymphokine production by T lymphocytes from patients with primary biliary cirrhosis[J].J Hepatol, 1994, 20 (4) :446-453.
|
[14] LLEO A, LIAO J, INVERNIZZI P, et al.Immunoglobulin M levels inversely correlate with CD40 ligand promoter methylation in patients with primary biliary cirrhosis[J].Hepatology, 2012, 55 (1) :153-160.
|
[15]KIKUCHI K, LIAN ZX, KIMURA Y, et al.Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis[J].J Autoimmun, 2005, 24 (4) :347-352.
|
[16]KIKUCHI K, LIAN ZX, YANG GX, et al.Bacterial CpG induces hyper-IgM production in CD27 (+) memory B cells in primary biliary cirrhosis[J].Gastroenterology, 2005, 128 (2) :304-312.
|
[17]UIBO R, KISAND K, YANG CY, et al.Primary biliary cirrhosis:a multi-faced interactive disease involving genetics, environment and the immune response[J].APMIS, 2012, 120 (11) :857-871.
|
[18]ARANBURU A, CECCARELLI S, GIORDA E, et al.TLR ligation triggers somatic hypermutation in transitional B cells inducing the generation of IgM memory B cells[J].J Immunol, 2010, 185 (12) :7293-7301.
|
[19]KUROSAKI T, AIBA Y, KOMETANI K, et al.Unique properties of memory B cells of different isotypes[J].Immunol Rev, 2010, 237 (1) :104-116.
|
[20]KIKUCHI K, TSUNEYAMA K, YAMADA H, et al.Splenic lymph follicles generate IgM producing B cells in primary biliary cirrhosis[J].Hepatol Res, 2013, doi: 10.1111/hepr.12231.
|
[21]MCNALLY RJ, JAMES PW, DUCKER S, et al.Seasonal variation in the patient diagnosis of primary biliary cirrhosis:further evidence for an environmental component to etiology[J].Hepatology, 2011, 54 (6) :2099-2103.
|
[22] DANIELS JA, TORBENSON M, ANDERS RA, et al.Immunostaining of plasma cells in primary biliary cirrhosis[J].Am J Clin Pathol, 2009, 131 (2) :243-249.
|
[23]LEE H, STAPP RT, ORMSBY AH, et al.The usefulness of IgG and IgM immunostaining of periportal inflammatory cells (plasma cells and lymphocytes) for the distinction of autoimmune hepatitis and primary biliary cirrhosis and their staining pattern in autoimmune hepatitis-primary biliary cirrhosis overlap syndrome[J].Am J Clin Pathol, 2010, 133 (3) :430-437.
|
[24]BJRKLAND A, LF L, MENDEL-HARTVIG I, et al.Primary biliary cirrhosis.High proportions of B cells in blood and liver tissue produce anti-mitochondrialantibodies of several Ig classes[J].J Immunol, 1994, 153 (6) :2750-2757.
|
[25]DHNRICH C, PARES A, CABALLERIA L, et al.New ELISA for detecting primary biliary cirrhosis-specific antimitochondrial antibodies[J].Clin Chem, 2009, 55 (5) :978-985.
|
[26]AMBROSINI YM, YANG GX, ZHANG W, et al.The multi-hit hypothesis of primary biliary cirrhosis:polyinosinic-polycytidylic acid (poly I:C) and murine autoimmune cholangitis[J].Clin Exp Immunol, 2011, 166 (1) :110-120.
|
[27]LEUNG PS, PARK O, TSUNEYAMA K, et al.Induction of primary biliary cirrhosis in guinea pigs following chemical xenobiotic immunization[J].J Immunol, 2007, 179 (4) :2651-2657.
|
[28]HIRSCHFIELD GM, GERSHWIN ME.The immunobiology and pathophysiology of primary biliary cirrhosis[J].Annu Rev Pathol, 2013, 8:303-330.
|
[29]BERG PA.The role of the innate immune recognition system in the pathogenesis of primary biliary cirrhosis:a conceptual view[J].Liver Int, 2011, 31 (7) :920-931.
|
[30]SFAKIANAKI O, TZARDI M, VOUMVOURAKI A, et al.Presence of disease specific autoantibodies against liver sinusoidal cells in primary biliary cirrhosis[J].World J Hepatol, 2013, 5 (10) :568-576.
|
[31]LLE A, BOWLUS CL, YANG GX, et al.Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis[J].Hepatology, 2010, 52 (3) :987-998.
|
[32]RONG G, ZHONG R, LLEO A, et al.Epithelial cell specificity and apotope recognition by serum autoantibodies in primary biliary cirrhosis[J].Hepatology, 2011, 54 (1) :196-203.
|
[33]BHANJI RA, MASON AL, GIRGIS S, et al.Liver transplantationfor overlap syndromes of autoimmune liver diseases[J].Liver Int, 2013, 33 (2) :210-219.
|