Correlation between HBV DNA load and ALT level: analysis of 800 patients with chronic hepatitis B

Objective To analyze the relationship between hepatitis B virus ( HBV) DNA load and serum alanine aminotransferase ( ALT) level and to investigate the reason that ALT level changes in patients with HBV infection. Methods ALT level ( dependent variable) and HBV DNA load ( independent variable) were subjected to curve fitting using SPSS 16. 0 to establish a curve regression equation and analyze the curve regression equation. Results A power model was established by software analysis, with the following results: R2= 0. 107, F = 85. 887, P = 0. 000, b0= 47. 785, b1= 0. 075, b2= 0. The curve analysis showed that as the HBV DNA load increased, the ALT level kept rising, but at a decreasing rate; within a certain range, the increase in HBV DNA load led to little change in ALT level, which was infinitely close to a certain value. Conclusion ALT level is correlated with HBV DNA load, but HBV DNA may not be the most direct cause of change in ALT level.