中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 5
May  2014
Turn off MathJax
Article Contents

Research progress in liver-specific miR-122 in regulating liver diseases

DOI: 10.3969/j.issn.1001-5256.2014.05.025
Research funding:

 

  • Published Date: 2014-05-20
  • MicroRNA- 122 ( miR- 122) , a liver- specific microRNA, has important functions in the physiological function and disease development of the liver. The association of miR- 122 with steatohepatitis and its possible action mechanism are described, and the effects of altered miR- 122 expression in regulating infections with hepatitis B virus and hepatitis C virus are discussed. In addition, the roles of miR- 122 in the development and progression of hepatocellular carcinoma are summarized. It is thought that the functions of miR- 122 in the liver provide a new target and therapeutic strategy for treatment of liver diseases.

     

  • loading
  • [1]WINTER J, JUNG S, KELLER S, et al.Many roads to maturity:miRNA biogenesis pathways and their regulation[J].Nature cell biology, 2009, 11 (3) :228-234.
    [2] MAKEYEV EV, MANIATIS T.Multilevel regulation of gene expression by miRNAs[J].Science Signaling, 2008, 319 (5871) :1789-1790.
    [3]HE MZ, ZHAO YL, LIU XD, et al.Screening and prediction of differential expression miRNA and their target genes in papillary thyroid carcinoma tissue[J].J Jilin Univ:Med Edit, 2013, 39 (1) :99-103. (in Chinese) 贺梦子, 赵银龙, 刘晓东, 等.甲状腺乳头状癌组织中差异表达miRNA及其靶基因的筛选和预测[J].吉林大学学报:医学版, 2013, 39 (1) :99-103.
    [4]HUANG XM, CHEN X, JAI ZY.Progress of artificial microRNAs in cancer gene therapy[J].Chin J Cell Biol, 2013, 35 (7) :1018-1026. (in Chinese) 黄晓明, 陈翔, 贾振宇.人工microRNAs在肿瘤基因治疗中的研究[J].中国细胞生物学学报, 2013, 35 (7) :1018-1026.
    [5]SONG YX, YUE ZY, WANG ZN, et al.MiRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation[J].Mol Cancer, 2011, 10 (1) :1-3.
    [6]LUAN T, TONG L, XU W, et al.MiR-122 stimulates the apoptosis of hepatoma cell Huh-7[J].Prati Oncol, 2012, 26 (5) :428-431. (in Chinese) 栾天, 佟雷, 徐威, 等.MiR-122促进原发性肝细胞癌Huh-7细胞凋亡[J].实用肿瘤学杂志, 2012, 26 (5) :428-431.
    [7]ESAU C, DAVIS S, MURRAY SF, et al.miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting[J].Cell metabolism, 2006, 3 (2) :87-98.
    [8]HSU S, WANG B, KOTA J, et al.Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver[J].J Clin Invest, 2012, 122 (8) :2871-2883.
    [9]TSAI WC, HSU SD, HSU CS, et al.MiRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis[J].J Clin Invest, 2012, 122 (8) :2884-2897.
    [10]DING X, DING J, NING J, et al.Circulating microRNA-122 as apotential biomarker for liver injury[J].Mol Med Rep, 202, 5 (6) :1428-1432.
    [11]LAUDADIO I, MANFROID I, ACHOURI Y, et al.A feedback loop between the liver-enriched transcription factor network and miR-122 controls hepatocyte differentiation[J].Gastroenterology, 2012, 142 (1) :119-129.
    [12]KARLMARK KR, WEISKIRCHEN R, ZIMMERMANN HW, et al.Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis[J].Hepatology, 2009, 50 (1) :261-274.
    [13]JOPLING CL, SCHTZ S, SARNOW P.Position-dependent function for a tandem miRNA miR-122-binding site located in the hepatitis C virus RNA genome[J].Cell Host Microbe, 2008, 4 (1) :77-85.
    [14]LINDENBACH BD, RICE CM.Unravelling hepatitis C virus replication from genome to function[J].Nature, 2005, 436 (7053) :933-938.
    [15]NORMAN KL, SARNOW P.Modulation of hepatitis C virus RNA abundance and the isoprenoid biosynthesis pathway by miRNA miR-122 involves distinct mechanisms[J].J Virol, 2010, 84 (1) :666-670.
    [16]VILLANUEVA RA, JANGRA RK, YI M, et al.miR-122 does not modulate the elongation phase of hepatitis C virus RNA synthesis in isolated replicase complexes[J].Antiviral Res, 2010, 88 (1) :119-123.
    [17]MACHLIN ES, SARNOW P, SAGAN SM.Masking the 5'terminal nucleotides of the hepatitis C virus genome by an unconventional miRNA-target RNA complex[J].Proc Natl Acad Sci U S A, 2011, 108 (8) :3193-3198.
    [18]WILSON JA, ZHANG C, HUYS A, et al.Human Ago2 is required for efficient miRNA 122 regulation of hepatitis C Virus RNA accumulation and translation[J].J virol, 2011, 85 (5) :2342-2350.
    [19]ROBERTS APE, LEWIS AP, JOPLING CL.miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA components[J].Nucleic Acids Res, 2011, 39 (17) :7716-7729.
    [20]LANFORD RE, HILDEBRANDT-ERIKSEN ES, PETRI A, et al.Therapeutic silencing of miRNA-122 in primates with chronic hepatitis C virus infection[J].Science, 2010, 327 (5962) :198-201.
    [21]SARASIN-FILIPOWICZ M, KROL J, MARKIEWICZ I, et al.Decreased levels of miRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy[J].Nat Med, 2009, 15 (1) :31-33.
    [22]HU J, XU Y, HAO J, et al.MiR-122 in hepatic function and liver diseases[J].Protein Cell, 2012, 3 (5) :364-371.
    [23]CHEN Y, SHEN A, RIDER PJ, et al.A liver-specific miRNA binds to a highly conserved RNA sequence of hepatitis B virus and negatively regulates viral gene expression and replication[J].FASEB J, 2011, 25 (12) :4511-4521.
    [24]FAN CG, WANG CM, TIAN C, et al.miR-122 inhibits viral replication and cell proliferation in hepatitis B virus-related hepatocellular carcinoma and targets NDRG3[J].Oncol Rep, 2011, 26 (5) :1281-1286.
    [25]WANG S, QIU L, YAN X, et al.Loss of miRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G1-modulated P53 activity[J].Hepatology, 2012, 55 (3) :730-741.
    [26]PEDERSEN IM, CHENG G, WIELAND S, et al.Interferon modulation of cellular miRNAs as an antiviral mechanism[J].Nature, 2007, 449 (7164) :919-922.
    [27]XU J, ZHU X, WU L, et al.MiRNA-122 suppresses cell proliferation and induces cell apoptosis in hepatocellular carcinoma by directly targeting Wnt/β-catenin pathway[J].Liver Int, 2012, 32 (5) :752-760.
    [28]ZENG C, WANG R, LI D, et al.A novel GSK-3 beta-C/EBP alpha-miR-122-insulin-like growth factor 1 receptor regulatory circuitry in human hepatocellular carcinoma[J].Hepatology, 2010, 52 (5) :1702-1712.
    [29]MIZUGUCHI Y, MISHIMA T, YOKOMURO S, et al.Sequencing and bioinformatics-based analyses of the miRNA transcriptome in hepatitis B-related hepatocellular carcinoma[J].PLoS One, 2011, 6 (1) :e15304.
    [30]KARAKATSANIS A, PAPACONSTANTINOU I, GAZOULI M, et al.Expression of miRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance[J].Mol Carcinog, 2013, 52 (4) :297-303.
    [31]ZHUANG P, LI ZY, WANG PC, et al.The functional characterization of the human liver-specific miR-122 expression in hepatocullar carcinoma[J].Chin J Immunol, 2013, 29 (7) :686-688. (in Chinese) 庄鹏, 李志莹, 王氵柏郴.肝特异性的miR-122对肝癌细胞增殖及凋亡的影响[J].中国免疫学杂志, 2013, 29 (7) :686-688.
    [32]WANG L, XU Y.MicroRNAs-the important participant in oncogenesis[J].China Med Herald, 2012, 9 (6) :15-17. (in Chinese) 王玲, 徐艳.MicroRNAs (miRNAs) ———肿瘤形成过程中的重要参与者[J].中国医药导报, 2012, 9 (6) :15-17.
    [33]BURCHARD J, ZHANG C, LIU AM, et al.miRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma[J].Mol Syst Biol, 2010, 6:402.
    [34]YANG YP.Current perspectives in preventive and therapeutic strategies for hepatocellular carcinoma[J].J Clin Hepatol, 2013, 29 (1) :1-4. (in Chinese) 杨永平.肝细胞癌防治热点与策略[J].临床肝胆病杂志, 2013, 29 (1) :1-4.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2776) PDF downloads(679) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return