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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2014
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The challenges to hepatitis C research in era of direct antiviral agents

DOI: 10.3969/j.issn.1001-5256.2014.06.001
  • Received Date: 2014-04-18
  • Published Date: 2014-06-20
  • Hepatitis C virus ( HCV) is an important human pathogen that causes chronic viral hepatitis worldwide. HCV infection, often persistent and asymptomatic, could lead to liver fibrosis /cirrhosis and hepatocellular carcinoma. The interferon /ribavirin therapy has been widely used for treating chronic hepatitis C, but it is not always effective and has strong side effects. The development of small- molecule direct antiviral agents ( DAA) has greatly improved the curing efficiency of chronic hepatitis C therapeutics and will likely replace the interferon- based therapy in the future. However, these developments do not necessarily suggest that the problems of chronic hepatitis C have been completely solved. The HCV research is still facing many challenges in this new DAA era.

     

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