中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2014
Turn off MathJax
Article Contents

Research progress in HBV /HCV co- infection

DOI: 10.3969/j.issn.1001-5256.2014.06.024
Research funding:

 

  • Received Date: 2014-02-10
  • Published Date: 2014-06-20
  • Hepatitis B virus ( HBV) is a hepatotropic DNA virus; HBV DNA and special P protein are covered by capsid proteins to form core particles, which are then covered by lipoprotein to form complete virus particles. Hepatitis C virus ( HCV) , which belongs to the Flaviviridae family, is a single- stranded, positive- sense RNA. HBV and HCV are transmitted by parenteral route and may cause co- infection through the same route of transmission. The pathogenesis of HBV /HCV co- infection and its relationship with occult HBV infection, hepatocellular carcinoma, organ transplantation, and HBV vaccine are reviewed. Meanwhile, the treatment of co- infection is presented. It is shown that HBV and HCV interfere with each other in terms of virology and pathology.

     

  • loading
  • [1]SORIANO V, VISPO E, LABARGA P, et al.Viral hepatitis and HIV co-infection[J].Antivir Res, 2010, 85 (1) :303-315.
    [2]DONG R, QIAO X, JIA W, et al.HIV, HCV, and HBV co-infections in a rural area of Shanxi province with a history of commercial blood donation[J].Biomed Environ Sci, 2011, 24 (3) :207-213.
    [3]CHU CJ, LEE SD.Hepatitis B virus/hepatitis C virus coinfection:epidemiology, clinical features, viral interactions and treatment[J].Gastroenterol Hepatol, 2008, 23 (4) :512-520.
    [4]GAETA GB, STORNAIUOLO G, PRECONE DF, et al.Epidemiological and clinical burden of chronic hepatitis B virus/hepatitis C virus infection[J].J Hepatol, 2003, 39 (6) :1036-1041.
    [5]LIAW YF, CHEN YC, SHEEN IS, et al.Impact of acute hepatitis C virus super-infection in patients with chronic hepatitis B virus infection[J].Gastroenterology, 2004, 126 (4) :1024-1029.
    [6]SQUADRITO G, ORLANDO ME, POLLICINO T, et al.Virological profiles in patients with chronic hepatitis C and overt or occult HBV infection[J].Am J Gastroenterol, 2002, 97 (6) :1518-1523.
    [7]ZHU FS, QIN YJ, CHENG ZJ, et al.The impact of HBV/HCV co-infection on HBV DNA levels and the severity of liver diseases in HBV-infected patients undergoing hemodialysis[J].J Clin Hepatol, 2013, 29 (2) :136-141. (in Chinese) 朱复生, 秦玉杰, 成振江, 等.丙型肝炎病毒/乙型肝炎病毒重叠感染对维持性血液透析患者HBV DNA水平及肝功能的影响[J].临床肝胆病杂志, 2013, 29 (2) :136-141.
    [8]MATHURIN P, THIBAULT V, KADIDJA K, et al.Replication status and histological features of patients with triple (B, C, D) and dual (B, C) hepatic infections[J].J Viral Hepat, 2000, 7 (1) :15-22.
    [9]MOREIRA M, RAMOS A, NETTO EM, et al.Characteristics of co-infections by HCV and HBV among Brazilian patients infected by HIV-1 and/or HTLV-1[J].Braz J Infect Dis, 2013, 17 (6) :661-666.
    [10]de ALMEIDA FB, CORRA CL, de SIQUEIRA NG, et al.Histopathological findings of an uncommon co-infection:Echinococcus vogeli, HIV, hepatitis C virus, and hepatitis B virus[J].Int J Infect Dis, 2013, 17 (10) :e925-e927.
    [11]BELLECAVE P, GOUTTENOIRE J, GAJER M, et al.Hepatitis B and C virus coinfection:a novel model system reveals the absence of direct viral interference[J].Hepatology, 2009, 50 (1) :46-55.
    [12]AZADMANESH K, MOHRAZ M, AGHAKHANI A, et al.Occult hepatitis B virus infection in HIV-infected patients with isolated hepatitis B core antibody[J].Intervirology, 2008, 51 (4) :270-274.
    [13]SQUADRITO G, CACCIOLA I, ALIBRANDI A, et al.Impact of occult hepatitis B virus infection on the outcome of chronic hepatitis C[J].J Hepatol, 2013, 59 (4) :696-700.
    [14]YUAN W, HUANG T, YU J, et al.Comparative analysis of viral protein interaction networks in Hepatitis B Virus and Hepatitis C Virus infected HCC[J].Biochim Biophys Acta, 2014, 1844 (1) :271-279.
    [15]CHANG ML, LIN YJ, CHANG CJ, et al.Occult and overt HBV co-infections independently predict postoperative prognosis in HCV-associated hepatocellular carcinoma[J].PLoS One, 2013, 8 (6) :e64891.
    [16]TAHA SE, EL-HADY AS, AHMED TM, et al.Detection of occult HBV infection by nested PCR assay among chronic hepatitis C patients with and without hepatocellular carcinoma[J].Egyp J Med Human Genetics, 2013, 14 (4) :353-360.
    [17]TANDOI F, ROMAGNOLI R, MARTINI S, et al.Outcomes of liver transplantation from hepatitis B core antibody-positive donors in viral cirrhosis patients:the prevailing negative effect of recipient hepatitis C virus infection[J].Transplant Proc, 2012, 44 (7) :1963-1965.
    [18]WANG JM, MA CJ, LI GY, et al.Tim-3 alters the balance of IL-12/IL-23 and drives TH17 cells:role in hepatitis B vaccine failure during hepatitis C infection[J].Vaccine, 2013, 31 (18) :2238-2245.
    [19]HAMZAOUI L, EL BOUCHTILI S, SIAI K, et al.Hepatitis B virus and hepatitis C virus co-infection:A therapeutic challenge[J].Clin Res Hepatol Gastroenterol, 2013, 37 (1) :e16-e20.
    [20]European Association for the Study of the Liver.EASL clinical practice guidelines:management of chronic hepatitis C virus infection[J].J Hepatol, 2014, 60 (2) :392-420.
    [21]European Association for the Study of the Liver.EASL clinical practice guidelines:management of chronic hepatitis B virus infection[J].J Hepatol, 2012, 57 (1) :167-185.
    [22]POTTHOFF A, WEDEMEYER H, BOECHER WO, et al.The HEP-NET B/C co-infection trial:A prospective multicenter study to investigate the efficacy of pegylated interferon-alpha 2b and ribavirin in patients with HBV/HCV co-infection[J].J Hepatol, 2008, 49 (5) :688-694.
    [23]COPPOLA N, STANZIONE M, MESSINA V, et al.Tolerability and efficacy of anti-HBV nucleos (t) ide analogues in HBV-DNA-positive cirrhotic patients with HBV/HCV dual infection[J].J Viral Hepat, 2012, 19 (12) :890-896.
    [24]HUNG CH, CHEN CH, LU SN, et al.Precore/core promoter mutations and hepatitis B virus genotype in hepatitis B and C dually infected patients treated with interferon-based therapy[J].Antiviral Res, 2012, 93 (1) :55-63.
    [25]LIU C, CHUANG W, LEE C, et al.Peginterferon alfa-2a plus ribavirin for the treatment of dual chronic infection with hepatitis B and C viruses[J].Gastroenterology, 2009, 136 (2) :496-504.
    [26]YU ML, LEE CM, CHEN CL, et al.Sustained hepatitis C virus clearance and increased hepatitis B surface antigen seroclearance in patients with dual chronic hepatitis C and B during posttreatment follow-up[J].Hepatology, 2013, 57 (6) :2135-2142.
    [27]URGANCI N, GULEC S, DOGAN S, et al.Interferon and ribavirin treatment results of patients with HBV-HCV co-infection cured of childhood malignancies[J].Int J Infect Dis, 2006, 10 (6) :453-457.
    [28]XIA W, CHEN F.Clinical signicance of HCV RNA assay in patients with HCV infection or coinfection of HBV[J].China Med Herald, 2012, 9 (13) :84-85. (in Chinese) 夏伟, 陈芳.HCV及其与HBV重叠感染患者血清HCV RNA检测的临床意义[J].中国医药导报, 2012, 9 (13) :84-85.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2992) PDF downloads(749) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return