中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 9
Sep.  2014
Turn off MathJax
Article Contents

Current status of research on liver innate immunity

DOI: 10.3969/j.issn.1001-5256.2014.09.003
Research funding:

 

  • Received Date: 2014-06-18
  • Published Date: 2014-09-20
  • Liver innate immunity plays an important role in the defense against pathogen invasion. The mechanisms of liver innate immunity for defending against pathogen invasion are reviewed, including the special anatomical and physiological characteristics of the liver, the features of innate immune cells in the liver ( liver- settled cells and cells raised from blood circulation) and their function and relationship with each other in pathogen invasion, the process of pathogen identification and effect of liver innate immune cells, and the mechanism of liver immune injury and immune tolerance. Given current research on innate immune cells and innate immune molecules in the liver, further studies should be conducted to understand the connection and difference between liver innate immunity and systemic immunity, thus promoting the diagnosis and treatment of liver diseases and deeper research.

     

  • loading
  • [1] BERG R.Bacterial translocation from the gastrointestinal tract[J].Trends Microbiol, 1995, 3 (4) :149-154.
    [2]LUMSDEN AB, HENDERSON JM, KUTNER MH.Endotoxin levels measured by a chrom ogenic assay in portal, hepatic and peripheral venous blood in patients with cirrhosis[J].Hepatology, 1988, 8 (2) :232-236.
    [3] BILZER M, ROGGEL F, GERBES AL.Role of Kupffer cells in host defense and liver disease[J].Liver Int, 2006, 26 (10) :1175-1186.
    [4]GALE RP, SPARKES RS, GOLDE DW.Bone marrow origin of hepatic macrophages (Kupffer cells) in humans[J].Science, 1978, 201 (4359) :937-938.
    [5] HELMY KY, KATSCHKE KJ, GORGANI NN, et al.CRIg:a macrophage complement receptor required for phagocytosis of circulating pathogens[J].Cell, 2006, 124 (5) :915-927.
    [6] EBE Y, HASEGAWA G, TAKATSUKA H, et al.The role of Kupffer cells and regulation of neutrophil migration into the liver by macrophage inflammatory protein-2 in primary listeriosis in mice[J].Pathol Int, 1999, 49 (6) :519-532.
    [7]YOU Q, CHENG L, KEDL RM, et al.Mechanism of T cell tolerance induction by murine hepatic Kupffer cells[J].Hepatology, 2008, 48 (3) :978-990.
    [8]LEE WY, MORIARTY TJ, WONG CH, et al.An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells[J].Nat Immunol, 2010, 11 (4) :295-302.
    [9]SHI J, GILBERT GE, KOKUBO Y, et al.Role of the liver in regulating numbers of circulating neutrophils[J].Blood, 2001, 98 (4) :1226-1230.
    [10] BOLTJES A, MOVITA D, BOONSTRA A, et al.The role of Kupffer cells in hepatitis B and hepatitis C virus infections[J].J Hepatol, 2014, 61 (3) :660-671.
    [11]RACANELLI V, REHERMANN B.The liver as an immunological organ[J].Hepatology, 2006, 43 (2 Suppl 1) :s54-s62.
    [12] WU J, MENG Z, JIANG M, et al.Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific[J].Immunology, 2010, 129 (3) :363-374.
    [13]NAHMIAS Y, CASALI M, BARBE L, et al.Liver endothelial cells promote LDL-R expression and the uptake of HCV-like particles in primary rat and human hepatocytes[J].Hepatology, 2006, 43 (2) :257-265.
    [14]BALAM S, ROMERO JF, BONGFEN SE, et al.C SP-a model for in vivo presentation of Plasmodium berghei sporozoite antigens by hepatocytes[J].PLoS One, 2012, 7 (12) :e51875.
    [15]FENG G, ZHANG JY, ZENG QL, et al.Interleukin-21 mediates hepatitis B virus-associated liver cirrhosis by activating hepatic stellate cells[J].Hepatol Res, 2013.[Epub ahead of print]
    [16] WINAU F, HEGASY G, WEISKIRCHEN R, et al.Ito cells are liver-resident antigen-presenting cells for activating T cell responses[J].Immunity, 2007, 26 (1) :117-129.
    [17]STEPTOE RJ, FU F, LI W, et al.Augmentation of dendritic cells in murine organ donors by Flt3 ligand alters the balance between transplant tolerance and immunity[J].J Immunol, 1997, 159 (11) :5483-5491.
    [18]KUDO S, MATSUNO K, EZAKI T, et al.A novel migration pathway for rat dendritic cells from the blood:hepatic sinusoids-lymph translocation[J].J Exp Med, 1997, 185 (4) :777-784.
    [19] ZHENG JM, SHI GF, LI N, et al.Study on type I interferon and phospho-IRF3 in murine liver dendritic cells after intervened by HBV[J].Chin J Hepatol, 2011, 19 (6) :450-453. (in Chinese) 郑建铭, 施光峰, 李宁, 等.乙型肝炎病毒干预后小鼠肝脏树突状细胞P-干扰素调节因子3表达的研究[J].中华肝脏病杂志, 2011, 19 (6) :450-453.
    [20]GOLDEN-MASON L, COX AL, RANDALL JA, et al.Increased natural killer cell cytotoxicity and NKp30 expression protects against hepatitis C virus infection in high-risk individuals and inhibits replication in vitro[J].Hepatology, 2010, 52 (5) :1581-1589.
    [21]ZEISSIG S, MURATA K, SWEET L, et al.Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity[J].Nat Med, 2012, 18 (7) :1060-1068.
    [22]YAMAGIWA S, MATSUDA Y, ICHIDA T, et al.Sustained response to interferon-alpha plus ribavirin therapy for chronic hepatitis C is closely associated with increased dynamism of intrahepatic natural killer and natural killer T cells[J].Hepatol Res, 2008, 38 (7) :664-672.
    [23] DIAO H, HE J, ZHENG Q, et al.A possible role for NKT-like cells in patients with chronic hepatitis B during telbivudine treatment[J].Immunol Lett, 2014, 160 (1) :65-71.
    [24] JENNE CN, WONG CH, ZEMP FJ, et al.Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps[J].Cell Host Microbe, 2013, 13 (2) :169-180.
    [25]IANNACONE M, SITIA G, ISOGAWA M, et al.Platelets mediate cytotoxic T lymphocyte-induced liver damage[J].Nat Med, 2005, 11 (11) :1167-1169.
    [26]SCHFER G, GULER R, MURRAY G, et al.The role of scavenger receptor B1 in infection with Mycobacterium tuberculosis in a murine model[J].PLoS One, 2009, 4 (12) :e8448.
    [27]EYRE NS, DRUMMER HE, BEARD MR.The SR-BI partner PDZK1 facilitates hepatitis C virus entry[J].PLoS Pathog, 2010, 6 (10) :e1001130.
    [28] WU J, MENG Z, JIANG M, et al.Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific[J].Immunology, 2010, 129 (3) :363-374.
    [29]WILKINS C, WOODWARD J, LAU DT, et al.IFITM1 is a tight junction protein that inhibits hepatitis C virus entry[J].Hepatology, 2013, 57 (2) :461-469.
    [30]BERG M, WINGENDER G, DJANDJI D, et al.Cross-presentation of antigens from apoptotic tumor cells by liver sinusoidal endothelial cells leads to tumor-specific CD8+T cell tolerance[J].Eur J Immunol, 2006, 36 (11) :2960-2970.
    [31]SEKI E, BRENNER DA.Toll-like receptors and adaptor molecules in liver disease:update[J].Hepatology, 2008, 48 (1) :322-335.引证本文:YE CT, WEI X, ZHANG Y.Current status of research on liver innate immunity[J].J Clin Hepatol, 2014, 30 (9) :846-850. (in Chinese) 叶传涛, 魏欣, 张颖.肝脏固有免疫系统研究现状[J].临床肝胆病杂志, 2014, 30 (9) :846-850.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (3107) PDF downloads(631) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return