中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 9
Sep.  2014
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Article Contents

Role of cancer- associated fibroblasts in growth and metastasis of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2014.09.007
  • Received Date: 2014-05-27
  • Published Date: 2014-09-20
  • The development and progression of tumors are closely related to the tumor microenvironment. As one of the most important components in tumor microenvironment, cancer- associated fibroblasts ( CAFs) play an important role in carcinogenesis, angiogenesis, invasion, and metastasis of tumors. The role of CAFs in the development and progression of hepatocellular carcinoma ( HCC) is reviewed by discussing how CAFs are recruited and activated in the tumor microenvironment and how CAFs promote tumor angiogenesis and regulate tumor immunity. This review may provide new approaches for the treatment of HCC.

     

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