Patients with liver FNH and HCC patients with negative AFP: plain and dynamic enhanced MRI and CT findings

Objective To investigate plain and dynamic enhanced magnetic resonance imaging(MRI) and computed tomography(CT)findings in patients with focal nodular hyperplasia(FNH) of the liver and hepatocellular carcinoma(HCC) patients with negative alpha-fetoprotein(AFP).Methods A statistical analysis was performed on the clinical data of 124 cases of liver tumor admitted to Beijing Miyun County Hospital from April 2012 to April 2014.Results Fifty-five of the 74 patients with FNH underwent CT examination,among whom38 patients received three-phase dynamic enhanced scan and 16 received only plain scan; 62 cases had plain and enhanced MRI with the application of contrast agent Gd-BOPTA in 42 patients.Among the 50 HCC patients with negative AFP,CT examination was performed in40 and 10 only had plain scan; 46 patients received plain and enhanced MRI with the use of contrast agent Gd-BOPTA in 30.Delayed scan after 1-2 h demonstrated low signal in 30 lesions of the 30 cases.Conclusion For patients with liver FNH and AFP-negative HCC patients,their plain and dynamic enhanced MRI and CT scan have respective characteristics.A combination of multiple examination methods can significantly improve diagnostic yield of the two diseases.