Objective To systematically evaluate the clinical efficacy of Liuweiwuling tablets in the treatment of non- alcoholic fatty liver disease( NAFLD),and to provide an evidence- based medicine basis for its clinical application. Methods Literature about Liuweiwuling tablets in the treatment of NAFLD published up to January 30,2015 was searched for in Cochrane Library,CNKI,Wanfang Data,and Pub Med. And the randomized controlled trials( RCTs) of Liuweiwuling tablets combined with conventional therapy( experimental group)versus conventional therapy( control group) for NAFLD were included in the analysis. The quality of included studies was assessed,and the data were extracted. And then they were subjected to meta- analysis using Rev Man 5. 2 to analyze the improvements in alanine aminotransferase( ALT),aspartate aminotransferase( AST),gamma- glutamyl transpeptidase( GGT),triglyceride( TG),clinical overall response rate,and imaging indices. Results A total of six RCTs were included in the analysis,involving 228 cases in the experimental group and205 cases in the control group. The analysis results showed that the experimental group had significantly reduced levels of ALT,AST,GGT,and TG compared with the control group( standardized mean difference [SMD] =- 1. 29,95% confidence interval [CI]:- 1. 69 ~- 0. 89,P < 0. 01; SMD =- 1. 15,95% CI:- 1. 85 ~- 0. 45,P < 0. 01; SMD =- 1. 47,95% CI:- 1. 68 ~- 1. 25,P < 0. 01; SMD =- 0. 48,95% CI:- 0. 60 ~- 0. 35,P < 0. 01). The experimental group had significantly higher clinical overall response rate and better improvements in imaging indices than the control group( relative risk [RR]= 1. 48,95% CI: 1. 29- 1. 70,P < 0. 01; RR = 1. 43,95%CI: 1. 21- 1. 68,P < 0. 01). Conclusion For patients with NAFLD,Liuweiwuling tablets combined with conventional therapy can significantly improve the liver function,reduce the blood lipid level,and increase the clinical overall response rate. However,since the quality of included literature is low,the reliability of the current meta- analysis conclusions should be further verified.
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