Association between GCKR gene rs780094( C > T) polymorphism and non- alcoholic fatty liver disease in Han population in Qingdao,China

Objective To investigate the association between glucokinase regulatory protein( GCKR) gene rs780094( C > T) polymorphism and non- alcoholic fatty liver disease( NAFLD) in the Han population in Qingdao,China. Methods A case- control study was conducted in 180 patients with NAFLD and 172 healthy controls. Blood samples were collected from all the subjects and were genotyped for rs780094 by polymerase chain reaction and DNA sequencing method. Genotype and allele frequencies were compared between the control and case groups. Results No significant differences between the two groups were observed in both genotype and allele frequencies( both P > 0. 05).The variant GCKR rs780094 T allele did not significantly increase the risk of NAFLD( OR = 1. 068,95% CI: 0. 748- 1. 525,P = 0. 719)compared with the C allele. Logistic regression model analysis adjusted for confounding factors exhibited that the TT + CT genotype of GCKR rs780094 did not significantly increase the risk of NAFLD relative to the CC genotype( P > 0. 05). Conclusion GCKR rs780094 T allele may be not associated with the increased risk of NAFLD in the Han population in Qingdao.