Objective To analyze the clinical characteristics of patients aged equal to or more than 80 years receiving multiple endoscopic retrograde cholangiopancreatography( ERCP) procedures and to evaluate the safety and efficacy of ERCP. Methods The clinical data were collected and retrospectively reviewed for patients aged 80 years or older who were admitted to the Gastroenterology Department of Beijing Army General Hospital and underwent ERCP at least twice from July 2010 to December 2014. Results Sixty patients( male 33,female 27)underwent 146 times of ERCP in total,among which 2 times were performed in 47 patients,3 times in 5 patients,4 times in 5 patients,5times in 2 patients,and 7 times in 1 patient. Postoperative events included hemorrhea after endoscopic sphincterotomy in 2 cases,post- ERCP acute pancreatitis in 1 case,and death within 3 weeks after ERCP in 2 cases due to chronic obstructive pulmonary disease. Conclusion Recurrent common bile duct stones and prolonged survival time of malignant tumor patients are the main reasons for repeated ERCP in elderly patients. As a whole,ERCP shows good safety and efficacy and improves the prognosis in elderly patients with biliopancreatic disorders.