Non- alcoholic fatty liver disease( NAFLD) affects up to a third of the population in developed countries. Between 10% and30% of patients with NAFLD have non- alcoholic steatohepatitis( NASH). There are metabolic risk factors common to both NAFLD and cardiovascular disease,so patients with NASH have an increased risk of liver- related and cardiovascular death. This articles reviews the most recent advances in the management of NAFLD in five main areas: lifestyle modification,weight loss treatment,therapy for metabolic syndrome,insulin sensitizer and antioxidant pharmacotherapy,and management of end- stage liver disease. It is pointed out that clinicians need to pay more attention to metabolic syndrome in the diagnosis and treatment of NAFLD.
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