Portal vein thrombosis( PVT) develops in some patients with liver cirrhosis and may aggravate portal hypertension. The risk factors for PVT have not yet been completely clarified. Splenectomy might increase the risk of developing PVT,which may progress to a life-threatening complication after splenectomy if not diagnosed promptly and treated properly. In this review,we discuss the recent findings concerning the risk factors for PVT after splenectomy. It is pointed out that splenectomy is the major cause of PVT developed in patients with liver cirrhosis.