|
[1]FILIPP FV.Cancer metabolism meets systems biology:pyruvate kinase isoform PKM2 is a metabolic master regulator[J].J Carcinog,2013,12(1):14.
|
|
[2]CHANETON B,GOTTLIEB E.Rocking cell metabolism:revised functions of the key glycolytic regulator PKM2 in cancer[J].Trends Biochem Sci,2012,37(8):309-316.
|
|
[3]MAZUREK S.Pyruvate kinase type M2:a key regulator of the metabolic budget system in tumor cells[J].Int J Biochem Cell Biol,2011,43(7):969-980.
|
|
[4] LV L,XU YP,ZHAO D,et al.Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization[J].Mol Cell,2013,52(3):340-352.
|
|
[5]CHIAVARINA B,WHITAKER-MENEZES D,MARTINEZ-OUT-SCHOORN UE,et al.Pyruvate kinase expression(PKM1 and PKM2)in cancer-associated fibroblasts drives stromal nutrient production and tumor growth[J].Cancer Biol Ther,2011,12(12):1101-1113.
|
|
[6]LEE J,KIM H K,HAN Y M,et al.Pyruvate kinase isozyme type M2(PKM2)interacts and cooperates with Oct-4 in regulating transcription[J].Int J Biochem Cell Biol,2008,40(5):1043-1054.
|
|
[7]PRIGIONE A,ROHWER N,HOFFMANN S,et al.HIF1alpha modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2[J].Stem Cells,2014,32(2):364-376.
|
|
[8]YANG W,XIA Y,JI H,et al.Nuclear PKM2 regulates betacatenin transactivation upon EGFR activation[J].Nature,2011,480(7375):118-122.
|
|
[9]YANG W,XIA Y,HAWKE D,et al.PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis[J].Cell,2012,150(4):685-696.
|
|
[10]GAO X,WANG H,YANG JJ,et al.Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase[J].Mol Cell,2012,45(5):598-609.
|
|
[11]LV L,XU YP,ZHAO D,et al.Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization[J].Mol Cell,2013,52(3):340-352.
|
|
[12]LO CH,FARINA F,MORRIS HP,et al.Glycolytic regulation in rat liver and hepatomas[J].Adv Enzyme Regul,1968,6:453-464.
|
|
[13]XU Q,LIU X,ZHENG X,et al.PKM2 regulates Gli1 expression in hepatocellular carcinoma[J].Oncol Lett,2014,8(5):1973-1979.
|
|
[14]CHRISTOFK HR,VANDER HEIDEN MG,HARRIS MH,et al.The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth[J].Nature,2008,452(7184):230-233.
|
|
[15]TAMADA M,SUEMATSU M,SAYA H.Pyruvate kinase M2:multiple faces for conferring benefits on cancer cells[J].Clin Cancer Res,2012,18(20):5554-5561.
|
|
[16]LUO W,SEMENZA GL.Emerging roles of PKM2 in cell metabolism and cancer progression[J].Trends Endocrinol Metab,2012,23(11):560-566.
|
|
[17]BLUEMLEIN K,GRUNING NM,FEICHTINGER RG,et al.No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis[J].Oncotarget,2011,2(5):393-400.
|
|
[18] VANDER HEIDEN MG,CANTLEY LC,THOMPSON CB.Understanding the warburg effect:the metabolic requirements of cell proliferation[J].Science(NY),2009,324(5930):1029-1033.
|
|
[19]HITOSUGI T,KANG S,VANDER HEIDEN MG,et al.Tyrosine phosphorylation inhibits PKM2 to promote the warburg effect and tumor growth[J].Sci Signal,2009,2(97):ra73.
|
|
[20]GAO X,WANG H,YANG JJ,et al.Reciprocal regulation of protein kinase and pyruvate kinase activities of pyruvate kinase M2 by growth signals[J].J Biol Chem,2013,288(22):15971-15979.
|
|
[21]ASHIZAWA K,WILLINGHAM MC,LIANG CM,et al.In vivo regulation of monomer-tetramer conversion of pyruvate kinase subtype M2 by glucose is mediated via fructose 1,6-bisphosphate[J].J Biol Chem,1991,266(25):16842-16846.
|
|
[22]ASHIZAWA K,MCPHIE P,LIN KH,et al.An in vitro novel mechanism of regulating the activity of pyruvate kinase M2 by thyroid hormone and fructose 1,6-bisphosphate[J].Biochemistry,1991,30(29):7105-7111.
|
|
[23]LV L,LI D,ZHAO D,et al.Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth[J].Mol Cell,2011,42(6):719-730.
|
|
[24]ANASTASIOU D,POULOGIANNIS G,ASARA JM,et al.Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses[J].Science(NY),2011,334(6060):1278-1283.
|
|
[25]KEFAS B,COMEAU L,ERDLE N,et al.Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells[J].Neuro Oncol,2010,12(11):1102-1112.
|
|
[26]ZHANG LF,LOU JT,LU MH,et al.Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma[J].EMBO J,2015,34(21):2671-2685.
|
|
[27]KOSUGI M,AHMAD R,ALAM M,et al.MUC1-C oncoprotein regulates glycolysis and pyruvate kinase M2 activity in cancer cells[J].PLoS One,2011,6(11):e28234.
|
|
[28]SHIMADA N,SHINAGAWA T,ISHII S.Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein[J].Genes Cells,2008,13(3):245-254.
|
|
[29]GUMINSKA M,STACHURSKA MB,IGNACAK J.Pyruvate kinase isoenzymes in chromatin extracts of Ehrlich ascites tumour,Morris hepatoma 7777 and normal mouse and rat livers[J].Biochim Biophys Acta,1988,966(2):207-213.
|
|
[30]DONG T,YAN Y,CHAI H,et al.Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1alpha and Bcl-xL in culture[J].Biomed Pharmacother,2015,69:277-284.
|
|
[31]HU W,LU SX,LI M,et al.Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma[J].Oncotarget,2015,6(9):6570-6583.
|
|
[32]CHEN Z,LU X,WANG Z,et al.Co-expression of PKM2 and TRIM35 predicts survival and recurrence in hepatocellular carcinoma[J].Oncotarget,2015,6(4):2538-2548.
|
|
[33]LIU WR,TIAN MX,YANG LX,et al.PKM2 promotes metastasis by recruiting myeloid-derived suppressor cells and indicates poor prognosis for hepatocellular carcinoma[J].Oncotarget,2015,6(2):846-861.
|
|
[34]CHEN SH,SHI WM,CHEN HL,et al.Further study on the value of M2-type pyvarate type kinase in the diagnosis of primary hepatocarcinoma[J].Chin J Oncol,1993,15(4):268-270.(in Chinese)陈士浩,施伟民,陈慧黎,等.M2型丙酮酸激酶对肝癌诊断意义的进一步研究[J].中华肿瘤杂志,1993,15(4):268-270.
|
|
[35]WANG C,DELOGU S,HO C,et al.Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways[J].J Hepatol,2012,57(3):577-583.
|
|
[36]LUO W,HU H,CHANG R,et al.Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1[J].Cell,2011,145(5):732-744.
|
|
[37]KITAMURA K,HATANO E,HIGASHI T,et al.Proliferative activity in hepatocellular carcinoma is closely correlated with glucose metabolism but not angiogenesis[J].J Hepatol,2011,55(4):846-857.
|
|
[38]TANAKA M,MASAKI Y,TANAKA K,et al.Reduction of fatty acid oxidation and responses to hypoxia correlate with the progression of de-differentiation in HCC[J].Mol Med Report,2013,7(2):365-570.
|
|
[39]SHEN YN,LU JH.Molecular targeted therapy for hepatocellular carcinoma[J].J Clin Hepatol,2015,31(1):130-134.(in Chinese)沈艺南,卢军华.肝细胞癌相关分子靶向治疗研究进展[J].临床肝胆病杂志,2015,31(1):130-134.
|
|
[40]FAN FT,SHEN CS,TAO L,et al.PKM2 regulates hepatocellular carcinoma cell epithelial-mesenchymal transition and migration upon EGFR activation[J].Asian Pac J Cancer Prev,2014,15(5):1961-1970.
|
|
[41]WONG CC,AU SL,TSE AP,et al.Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis[J].PLoS One,2014,9(12):e115036.
|
|
[42]ZHANG X,HE C,HE C,et al.Nuclear PKM2 expression predicts poor prognosis in patients with esophageal squamous cell carcinoma[J].Pathol Res Pract,2013,209(8):510-515.
|
|
[43]LIM JY,YOON SO,SEOL SY,et al.Overexpression of the M2isoform of pyruvate kinase is an adverse prognostic factor for signet ring cell gastric cancer[J].World J Gastroenterol,2012,18(30):4037-4043.
|
|
[44]WONG N,YAN J,OJO D,et al.Changes in PKM2 associate with prostate cancer progression[J].Cancer Invest,2014,32(7):330-338.
|
|
[45]TONUS C,SELLINGER M,KOSS K,et al.Faecal pyruvate kinase isoenzyme type M2 for colorectal cancer screening:a meta-analysis[J].World J Gastroenterol,2012,18(30):4004-4011.
|
|
[46]MENG W,ZHU HH,XU ZF,et al.Serum M2-pyruvate kianse:a promising non-invasive biomarker for colorectal cancer mass screening[J].World J Gastroenterol,2012,4(6):145-151.
|
|
[47]GOLDBERG MS,SHARP PA.Pyruvate kinase M2-specific siR-NA induces apoptosis and tumor regression[J].J Exp Med,2012,209(2):217-224.
|
|
[48]YANG W,XIA Y,CAO Y,et al.EGFR-induced and PKCepsilon monoubiquitylation-dependent NF-kappaB activation upregulates PKM2 expression and promotes tumorigenesis[J].Molecular cell,2012,48(5):771-784.
|
|
[49]GORRINI C,HARRIS IS,MAK TW.Modulation of oxidative stress as an anticancer strategy[J].Nat Rev Drug Discov,2013,12(12):931-947.
|
|
[50]JUNG Y,JANG YJ,KANG MH,et al.Metabolic signature genes associated with susceptibility to pyruvate kinase,muscle type 2 gene ablation in cancer cells[J].Mol Cells,2013,35(4):335-341.
|
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