中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2016
Turn off MathJax
Article Contents

Research advances in treatment of cirrhotic ascites

DOI: 10.3969/j.issn.1001-5256.2016.06.009
Research funding:

 

  • Received Date: 2016-03-09
  • Published Date: 2016-06-20
  • Ascites is the most common complication of liver cirrhosis,and prevention and control of the development and progression of ascites are the key to improving the prognosis of patients with liver cirrhosis.This article summarizes the new advances in the treatment of ascites,including the update on first- line therapeutic methods such as etiological treatment,limited intake of sodium,and diuretic treatment,and investigates the treatment of intractable ascites.

     

  • loading
  • [1]RUNYON BA,AASLD.Introduction to the revised American Association for the Study of Liver Diseases Practice Guideline management of adult patients with ascites due to cirrhosis 2012[J].Hepatology,2013,57(4):1651-1653.
    [2]PLANAS R,MONTOLIU S,BALLESTE B,et al.Natural history of patients hospitalized for management of cirrhotic ascites[J].Clin Gastroenterol Hepatol,2006,4(11):1385-1394.
    [3]HONDA K,SEIKE M,MURAKAMI K.Benefits of nucleos(t)ide analog treatments for hepatitis B virus-related cirrhosis[J].World J Hepatol,2015,7(22):2404-2410.
    [4]KIM MS,ONG M,QU X.Optimal management for alcoholic liver disease:conventional medications,natural therapy or combination?[J].World J Gastroenterol,2016,22(1):8-23.
    [5]BIECKER E.Diagnosis and therapy of ascites in liver cirrhosis[J].World J Gastroenterol,2011,17(10):1237-1248.
    [6]SOLE,SOLC,GINS P.Management of uninfected and infected ascites in cirrhosis[J].Liver Int,2016,36(Suppl 1):109-115.
    [7] LENZ K,BUDER R,KAPUN L,et al.Treatment and management of ascites and hepatorenal syndrome:an update[J].Therap Adv Gastroenterol,2015,8(2):83-100.
    [8] European Association for the Study of the Liver.EASL clinical practice guidelines on the management of ascites,spontaneous bacterial peritonitis,and hepatorenal syndrome in cirrhosis[J].J Hepatol,2010,53(3):397-417.
    [9] PEREZ-AYUSO RM,ARROYO V,PLANAS R,et al.Randomized comparative study of efficacy of furosemide versus spironolactone in nonazotemic cirrhosis with ascites.Relationship between the diuretic response and the activity of the renin-aldosterone system[J].Gastroenterology,1983,84(5 Pt 1):961-968.
    [10] BERNARDI M,SERVADEI D,TREVISANI F,et al.Importance of plasma aldosterone concentration on the natriuretic effect of spironolactone in patients with liver cirrhosis and ascites[J].Digestion,1985,31(4):189-193.
    [11] ANGELI P,FASOLATO S,MAZZA E,et al.Combined versus sequential diuretic treatment of ascites in non-azotaemic patients with cirrhosis:results of an open randomised clinical trial[J].Gut,2010,59(1):98-104.
    [12] ANGELI P,WONG F,WATSON H,et al.Hyponatremia in cirrhosis:results of a patient population survey[J].Hepatology,2006,44(6):1535-1542.
    [13]ALESSANDRIA C,ELIA C,MEZZABOTTA L,et al.Prevention of paracentesis-induced circulatory dysfunction in cirrhosis:standard vs half albumin doses.A prospective,randomized,unblinded pilot study[J].Dig Liver Dis,2011,43(11):881-886.
    [14]MANDORFER M,BOTA S,SCHWABL P,et al.Nonselective beta blockers increase risk for hepatorenal syndrome and death in patients with cirrhosis and spontaneous bacterial peritonitis[J].Gastroenterology,2014,146(7):1680-1690.
    [15] LEITHEAD JA,RAJORIYA N,TEHAMI N,et al.Non-selective beta-blockers are associated with improved survival in patients with ascites listed for liver transplantation[J].Gut,2015,64(7):1111-1119.
    [16] KRAG A,MADSEN BS.To block,or not to block in advanced cirrhosis and ascites:that is the question[J].Gut,2015,64(7):1015-1017.
    [17]GUO TT,YANG Y,SONG Y,et al.Effects of midodrine in patients with ascites due to cirrhosis:systematic review and meta-analysis[J].J Dig Dis,2016,17(1):11-19.
    [18]BARI K,MINANO C,SHEA M,et al.The combination of octreotide and midodrine is not superior to albumin in preventing recurrence of ascites after large-volume paracentesis[J].Clin Gastroenterol Hepatol,2012,10(10):1169-1175.
    [19]BELLOT P,WELKER MW,SORIANO G,et al.Automated low flow pump system for the treatment of refractory ascites:a multicenter safety and efficacy study[J].J Hepatol,2013,58(5):922-927.
    [20] THOMAS MN,SAUTER GH,GERBES AL,et al.Automated low flow pump system for the treatment of refractory ascites:a singlecenter experience[J].Langenbecks Arch Surg,2015,400(8):979-983.
    [21]PONZIANI FR.Effect of rifaximin on gut microbiota composition in advanced liver disease and its complications[J].World J Gastroenterol,2015,21(43):12322.
    [22] ASSEM M,ELSABAAWY M,ABDELRASHED M,et al.Efficacy and safety of alternating norfloxacin and rifaximin as primary prophylaxis for spontaneous bacterial peritonitis in cirrhotic ascites:a prospective randomized open-label comparative multicenter study[J].Hepatol Int,2016,10(2):377-385.
    [23] Liver Failure and Artificial Liver Group,Chinese Society of Infectious Diseases,Chinese Medical Association;Severe Liver Diseases and Artificial Liver Group,Chinese Society of Hepatology,Chinese Medical Association.Guidelines for diagnosis and treatment liver failure[J].Chin J Clin Infect Dis,2012,5(6):321-327.(in Chinese)中华医学会感染病学分会肝衰竭与人工肝学组,中华医学会肝病学分会重型肝病与人工肝学组.肝衰竭诊治指南(2012年版)[J].中华临床感染病杂志,2012,5(6):321-327.
    [24]SOLA E,GINES P.Renal and circulatory dysfunction in cirrhosis:current management and future perspectives[J].J Hepatol,2010,53(6):1135-1145.
    [25] WONG F.Recent advances in our understanding of hepatorenal syndrome[J].Nat Rev Gastroenterol Hepatol,2012,9(7):382-391.
    [26]SERSTE T,GUSTOT T,RAUTOU PE,et al.Severe hyponatremia is a better predictor of mortality than MELDNa in patients with cirrhosis and refractory ascites[J].J Hepatol,2012,57(2):274-280.
    [27] STOCKAND JD.Vasopressin regulation of renal sodium excretion[J].Kidney Int,2010,78(9):849-856.
    [28] YAMAMURA Y,NAKAMURA S,ITOH S,et al.OPC-41061,a highly potent human vasopressin V2-receptor antagonist:pharmacological profile and aquaretic effect by single and multiple oral dosing in rats[J].J Pharmacol Exp Ther,1998,287(3):860-867.
    [29]SAKAIDA I,KAWAZOE S,KAJIMURA K,et al.Tolvaptan for improvement of hepatic edema:a phase 3,multicenter,randomized,double-blind,placebo-controlled trial[J].Hepatol Res,2014,44(1):73-82.
    [30] IMAMURA T,KINUGAWA K,MINATSUKI S,et al.Urine sodium excretion after tolvaptan administration is dependent upon baseline serum sodium levels[J].Int Heart J,2014(14):131-137.
    [31] SAKAIDA I,NAKAJIMA K,OKITA K,et al.Can serum albumin level affect the pharmacological action of tolvaptan in patients with liver cirrhosis?A post hoc analysis of previous clinical trials in Japan[J].J Gastroenterol,2015,50(10):1047-1053.
    [32] SHOAF SE,BRICMONT P,MALLIKAARJUN S.Pharmacokinetics and pharmacodynamics of oral tolvaptan in patients with varying degrees of renal function[J].Kidney Int,2014,85(4):953-961.
    [33]GOLDSMITH SR,BART BA,BURNETT J.Decongestive therapy and renal function in acute heart failure:time for a new approach?[J].Circ Heart Fail,2014,7(3):531-535.
    [34] VADUGANATHAN M,GHEORGHIADE M,PANG PS,et al.Efficacy of oral tolvaptan in acute heart failure patients with hypotension and renal impairment[J].J Cardiovasc Med(Hagerstown),2012,13(7):415-422.
    [35]UDELSON JE,ORLANDI C,OUYANG J,et al.Acute hemodynamic effects of tolvaptan,a vasopressin V2 receptor blocker,in patients with symptomatic heart failure and systolic dysfunction:an international,multicenter,randomized,placebo-controlled trial[J].J Am Coll Cardiol,2008,52(19):1540-1545.
    [36]CARDENAS A,GINES P,MAROTTA P,et al.Tolvaptan,an oral vasopressin antagonist,in the treatment of hyponatremia in cirrhosis[J].J Hepatol,2012,56(3):571-578.
    [37]AHLUWALIA V,HEUMAN DM,FELDMAN G,et al.Correction of hyponatremia improves cognition,quality of life,and brain edema in cirrhosis[J].J Hepatol,2015,1(62):75-82.
    [38] KOGISO T,TOKUSHIGE K,HASHIMOTO E,et al.Safety and efficacy of long-term tolvaptan therapy for decompensated liver cirrhosis[J].Hepatol Res,2016,46(3):e194-e200.
    [39]ZHANG X,WANG SZ,ZHENG JF,et al.Clinical efficacy of tolvaptan for treatment of refractory ascites in liver cirrhosis patients[J].World J Gastroenterol,2014,20(32):11400-11405.
    [40]OHKI T,SATO K,YAMADA T,et al.Efficacy of tolvaptan in patients with refractory ascites in a clinical setting[J].World J Hepatol,2015,7(12):1685-1693.
    [41] TORRES VE,CHAPMAN AB,DEVUYST O,et al.Tolvaptan in patients with autosomal dominant polycystic kidney disease[J].NEngl J Med,2012,367(25):2407-2418.
    [42] WATKINS PB,LEWIS JH,KAPLOWITZ N,et al.Clinical pattern of tolvaptan-associated liver injury in subjects with autosomal dominant polycystic kidney disease:analysis of clinical trials database[J].Drug Saf,2015,38(11):1103-1113.
    [43] YAN L,XIE F,LU J,et al.The treatment of vasopressin V2-receptor antagonists in cirrhosis patients with ascites:a meta-analysis of randomized controlled trials[J].BMC Gastroenterol,2015,15:65.
    [44]PERICLEOUS M,SARNOWSKI A,MOORE A,et al.The clinical management of abdominal ascites,spontaneous bacterial peritonitis and hepatorenal syndrome:a review of current guidelines and recommendations[J].Eur J Gastroenterol Hepatol,2016,28(3):e10-e18.
    [45] WONG F,WATSON H,GERBES A,et al.Satavaptan for the management of ascites in cirrhosis:efficacy and safety across the spectrum of ascites severity[J].Gut,2012,61(1):108-116.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2504) PDF downloads(639) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return