Association between non-high-density lipoprotein cholesterol and nonalcoholic fatty liver disease in postmenopausal Uyghur women in Xinjiang,China

Objective To investigate the association between non- high- density lipoprotein cholesterol(non- HDL- C) and nonalcoholic fatty liver disease(NAFLD) in postmenopausal Uyghur women in Xinjiang,China.Methods A total of 1271 postmenopausal Uyghur women who underwent physical examination in the physical examination centers of hospitals in the First Affiliated Hospital of Urumqi and the First People's Hospital of Kashgar,Xinjiang,were enrolled as study subjects,and according to the presence or absence of NAFLD,they were divided into NAFLD group(682 women) and control group(589 women).Demographic data were recorded in detail,and the hepatic enzyme parameters,parameters for glucose and lipid metabolism,and parameters including uric acid and non- HDL- C were measured.The t- test was used for comparison of continuous data between groups,the chi- square test was used for comparison of categorical data between groups,and non- conditional logistic regression analysis was used to determine the risk factors for NAFLD in postmenopausal women.Results Compared with the control group,the NAFLD group had significantly higher uric acid,fasting blood glucose,triglyceride(TG),glycosylated hemoglobin,alanine aminotransferase(ALT),aspartate aminotransferase(AST),waist circumference,hip circumference,body mass index,waist- hip ratio,and non- HDL- C level(all P < 0.05),and a significantly lower HDL- C and adiponection level(all P < 0.05).Compared with the group with a non- HDL- C level of ≥3.58 mmol / L,the group with a non- HDL- C level of < 3.58 mmol / L had significantly lower levels of blood glucose,total cholesterol,TG,AST,ALT,and low- density lipoprotein cholesterol.The multivariate logistic regression analysis showed that non- HDL- C,serum uric acid,and BMI were risk factors for NAFLD in postmenopausal women.Conclusion Non- HDL- C,along with central obesity,hypertriglyceridemia,and hyperuricemia,is a major risk factor for NAFLD in postmenopausal women.