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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2016
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Article Contents

Research advances in the role of aquaporins in liver fibrosis and liver cirrhosis

DOI: 10.3969/j.issn.1001-5256.2016.06.041
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  • Received Date: 2016-01-05
  • Published Date: 2016-06-20
  • Liver fibrosis is the final outcome of various chronic liver diseases,and various cells,cytokines,and miRNAs are involved in the development and progression of liver fibrosis and liver cirrhosis.Hepatic fibrosis and pathologic angiogenesis are interdependent processes and promote each other,but the physiopathological mechanism of arterial capillary proliferation in liver fibrosis remains unknown.Aquaporins not only transport water molecules,but also promote angiogenesis.This article briefly introduces the expression of aquaporins in the hepatobiliary system and their physiological and biochemical characteristics and summarizes the role of aquaporins in the progression of liver fibrosis and liver cirrhosis,in order to provide new thoughts and guidance for aquaporins as the target in the treatment of liver fibrosis and liver cirrhosis.

     

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