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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2016
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Article Contents

Advances in basic research on mesenchymal stem cells and its clinical application in liver cirrhosis

DOI: 10.3969/j.issn.1001-5256.2016.06.042
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  • Received Date: 2015-11-27
  • Published Date: 2016-06-20
  • Adult mesenchymal stem cells(MSCs) have the features of high plasticity and low immunogenicity,and hold promise for wide clinical application.This article reviews the basic research on MSCs in bone marrow and umbilical cord blood and their clinical application in liver diseases to lay a theoretical foundation and provide support for their clinical application in liver cirrhosis,and to provide more technical measures for the treatment of end- stage liver disease.However,the safety and efficacy in clinical application still need further studies.

     

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  • [1]MEIER RP,MAHOU R,MOREL P,et al.Microencapsulated human mesenchymal stem cells decrease liver fibrosis in mice[J].JHepatol,2015,62(3):634-641.
    [2]SATO Y,ARAKI H,KATO J,et al.Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion[J].Blood,2005,106(2):756-763.
    [3]CHIVU M,DIMA SO,STANCU CI,et al.In vitro hepatic differentiation of human bone marrow mesenchymal stem cells under differential exposure to liver-specific factors[J].Transl Res,2009,154(3):122-132.
    [4]OYAGI S,HIROSE M,KOJIMA M,et al.Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats[J].J Hepatol,2006,44(4):742-748.
    [5]ZHANG LT,CHEN H,FENG L,et al.Human bone marrow mesenchymal stem cells differentiating into hepatocyte-like cells after being induced by co-culturing with human hepatocyte line L02[J].Shandong Med J,2008,48(24):4-6.(in Chinese)张立婷,陈红,冯利,等.人肝细胞L02诱导MSCs分化为肝样细胞的观察[J].山东医药,2008,48(24):4-6.
    [6]LAM SP,LUK JM,MAN K,et al.Activation of interleukin-6-induced glycoprotein 130/signal transducer and activator of transcription 3 pathway in mesenchymal stem cells enhances hepatic differentiation,proliferation,and liver regeneration[J].Liver Transpl,2010,16(10):1195-1206.
    [7]YAN XM,ZHANG LT,LUO JY,et al.Therapeutic effect of estradiol-pretreated human bone marrow mesenchymal stem cells on liver cirrhosis in mice[J].J Clin Hepatol,2015,31(2):424-430.(in Chinese)颜小明,张立婷,骆菁怡,等.雌二醇预处理的人骨髓间充质干细胞对实验性小鼠肝硬化模型的疗效对比研究[J].临床肝胆病杂志,2015,31(2):424-430.
    [8]ZHANG LT,WANG S,LI JF,et al.Effect of human bone marrow mesenchymal stem cell supernatant on proliferation cycle and MMP-1expression of hepatic stellate cells[J].J Clin Hepatol,2012,28(11):836-838.(in Chinese)张立婷,王珊,李俊峰,等.人骨髓间充质干细胞上清液对体外肝星状细胞增殖周期及MMP-1表达的影响[J].临床肝胆病杂志,2012,28(11):836-838.
    [9]WANG S,WANG LT,CHEN H.Effect of human bone marrow mesenchymal stem cells culture supernatant on related enzyme expression in hepatic stellate cells[J].J Clin Rehabil Tissue Eng Res,2012,16(45):8374-8379.(in Chinese)王珊,张立婷,陈红.人骨髓间充质干细胞培养上清与肝星状细胞相关酶的分泌[J].中国组织工程研究,2012,16(45):8374-8379.
    [10]ZHANG LT,FANG XQ,CHEN QF,et al.Bone marrow-derived mesenchymal stem cells inhibit the proliferation of hepatic stellate cells by inhibiting the transforming growth factor beta pathway[J].Mol Med Rep,2015,12(5):7227-7232.
    [11]MOHAMADNEJAD M,ALIMOGHADDAM K,MOHYEDDIN-BONAB M,et al.Phase 1 trial of autologous bone marrow mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis[J].Arch Iran Med,2007,10(4):459-466.
    [12]KHARAZIHA P,HELLSTROM PM,NOORINAYER B,et al.Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection:a phaseⅠ-Ⅱclinical trial[J].Eur J Gastroenterol Hepatol,2009,21(10):1199-1205.
    [13]PENG L,XIE DY,LIN BL,et al.Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B:short-term and long-term outcomes[J].Hepatology,2011,54(3):820-828.
    [14]KAKINUMA S,TANAKA Y,CHINZEI R,et al.Human umbilical cord blood as a source of transplantable hepatic progenitor cells[J].Stem Cells,2003,21(2):217-227.
    [15]NEWSOME PN,JOHANNESSEN I,BOYLE S,et al.Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion[J].Gastroenterology,2003,124(7):1891-1900.
    [16]LEE OK,KUO TK,CHEN WM,et al.Isolation of multipotent mesenchymal stem cells from umbilical cord blood[J].Blood,2004,103(5):1669-1675.
    [17]HONG SH,GANG EJ,JEONG JA,et al.In vitro differentiation of human umbilical cord blood-derived mesenchymal stem cells into hepatocyte-like cells[J].Biochem Biophys Res Commun,2005,330(4):1153-1161.
    [18]ZHAO Q,REN H,LI X,et al.Differentiation of human umbilical cord mesenchymal stromal cells into low immunogenic hepatocyte-like cells[J].Cytotherapy,2009,11(4):414-426.
    [19]YAN Y,XU W,QIAN H,et al.Mesenchymal stem cells from human umbilical cords ameliorate mouse hepatic injury in vivo[J].Liver Int,2009,29(3):356-365.
    [20]JUNG KH,UHM YK,LIM YJ,et al.Human umbilical cord blood-derived mesenchymal stem cells improve glucose homeostasis in rats with liver cirrhosis[J].Int J Oncol,2011,39(1):137-143.
    [21]REN H,ZHAO Q,CHENG T,et al.No contribution of umbilical cord mesenchymal stromal cells to capillarization and venularization of hepatic sinusoids accompanied by hepatic differentiation in carbon tetrachloride-induced mouse liver fibrosis[J].Cytotherapy,2010,12(3):371-383.
    [22]ZHANG Z,LIN H,SHI M,et al.Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients[J].J Gastroenterol Hepatol,2012,27(Suppl 2):112-120.
    [23]WANG L,LI J,LIU H,et al.Pilot study of umbilical cord-derived mesenchymal stem cell transfusion in patients with primary biliary cirrhosis[J].J Gastroenterol Hepatol,2013,28(Suppl 1):85-92.
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