中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2016
Turn off MathJax
Article Contents

Association between dynamic changes in HBsAg and progression of chronic hepatitis B

DOI: 10.3969/j.issn.1001-5256.2016.06.044
Research funding:

 

  • Published Date: 2016-06-20
  • With the application of HBs Ag quantification in clinical practice,recent studies have found that HBs Ag level can not only reflect the transcriptional activity of double- stranded covalently closed circular DNA,but also predict the risk of disease progression and response to antiviral therapy in patients with chronic HBV infection.This article reviews the changes in HBs Ag level in the natural course of HBV infection and points out the changes in HBs Ag level can provide new ideas to the treatment of chronic hepatitis B.

     

  • loading
  • [1] SEEGER C,MASON WS.Hepatitis B virus biology[J].Microbiol Mol Biol Rev,2000,64(1):51-68.
    [2]ZHOU B,LIU M,LV G,et al.Quantification of hepatitis B surface antigen and E antigen:correlation between Elecsys and Architect assays[J].J Viral Hepat,2013,20(6):422-429.
    [3]CHAN HL,WONG VW,WONG GL,et al.Alongitudinal study on the natural history of serum hepatitis B surface antigen changes in chronic hepatitis B[J].Hepatology,2010,52(4):1232-1241.
    [4]JAROSZEWICZ J,CALLE SK,WURSTHORN K,et al.Hepatitis B surface antigen(HBs Ag)levels in the natural history of hepatitis Bvirus(HBV)-infection:a European perspective[J].J Hepatol,2010,52(4):514-522.
    [5]NGUYEN T,THOMPSON AJ,BOWDEN S,et al.Hepatitis B surface antigen levels during the natural history of chronic hepatitis B:a perspective on Asia[J].J Hepatol,2010,52(4):508-513.
    [6]ZHOU HB,LI JY,ZHAO YH,et al.Quantitation of hepatitis Bsurface antigen(HBs Ag)in the natural course of hepatitis B virus(HBV)-infection[J].J Harbin Med Univ,2013,47(4):350-352.(in Chinese)周洪波,李晶媛,赵勇华,等.乙型肝炎病毒感染不同阶段HBs Ag定量变化的研究[J].哈尔滨医科大学学报,2013,47(4):350-352.
    [7] YUEN MF,WONG DK,SABLON E,et al.HBs Ag seroclearance in chronic hepatitis B in the Chinese:virological,histological,and clinical aspects[J].Hepatology,2004,39(6):1694-1701.
    [8]RIJCKBORST V,HANSEN BE,CAKALOGLU Y,et al.Early ontreatment prediction of response to peginterferon alfa-2a for HBe Ag-negative chronic hepatitis B using HBs Ag and HBV DNA levels[J].Hepatology,2010,52(2):454-461.
    [9]BRUNETTO MR,MORICONI F,BONINO F,et al.Hepatitis Bvirus surface antigen levels:a guide to sustained response to peginterferon alfa-2a in HBe Ag-negative chronic hepatitis B[J].Hepatology,2009,49(4):1141-1150.
    [10]BRUNETTO MR,OLIVERI F,COLOMBATTO P,et al.Hepatitis B surface antigen serum levels help to distinguish active from inactive hepatitis B virus genotype D carriers[J].Gastroenterology,2010,139(2):483-490.
    [11]MARTINOT-PEIGNOUX M,CARVALHO-FILHO R,LAPA-LUS M,et al.Hepatitis B surface antigen serum level is associated with fibrosis severity in treatment-nave,e antigen-positive patients[J].J Hepatol,2013,58(6):1089-1095.
    [12] JAROSZEWICZ J,CALLE SERRANO B,WURSTHORN K,et al.Hepatitis B surface antigen(HBs Ag)levels in the natural history of hepatitis B virus(HBV)-infection:a European perspective[J].JHepatol,2010,52(4):514-522.
    [13]European Association for the Study of the Liver.EASL clinical practice guidelines:managementof chronic hepatitis B virus infection[J].J Hepatol,2012,57(1):167-185.
    [14] HAN XY,CHEN XJ,YAN ZQ,et al.Correlation among HBs Ag and HBV DNA levels with liver fibrosis in patients with hepatitis B[J].Int J Virol,2016,23(1):50-56.(in Chinese)韩晓颖,陈秀记,闫泽强,等.血清HBs Ag与HBV DNA水平与乙肝患者肝纤维化程度的相关性分析[J].国际病毒学杂志,2016,23(1):50-56.
    [15]PEI YZ,HAN T,MA XY,et al.The discrepancy of HBs Ag titre and HBV DNA in patients with chronic hepatitis B,HBV-related liver cirrhosis and hepatocellular carcinoma[J].Chin J Hepatol,2011,19(10):743-746.(in Chinese).裴彦祯,韩涛,马晓艳,等.HBs Ag及HBV DNA定量水平在慢性乙型肝炎、肝硬化和肝癌患者中的变化[J].中华肝脏病杂志,2011,19(10):743-746.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2072) PDF downloads(465) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return