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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2016
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Article Contents

Immunological characteristics of tumor antigen specific T cells and their possible mechanisms in hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2016.06.048
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  • Published Date: 2016-06-20
  • Hepatocellular carcinoma(HCC) is a major health problem around the world and its morbidity is increasing year by year.HCC has a low rate of early diagnosis and advanced HCC has a low survival rate.Therefore,the diagnosis and treatment of HCC has attracted great attention,and tumor specific T cell immunity plays an important role in it.This article describes the immunological characteristics of seven HCC- associated antigen specific T cells,i.e.,alpha fetal protein,phosphatidylinositol proteoglycan- 3,NY- ESO- 1,SSX- 2,melanoma antigen gene A,telomerase reverse transcriptase,and HCC- associated antigen- 519 / target protein xklp- 2,and analyzes the possible mechanisms which affect antigen specific T cell immunity from the aspects of regulatory T cells,myeloid- derived suppressor cells,antigen presenting and processing,inhibitory receptors,and CD4+T cells.

     

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