[1] BREITFELD D,OHL L,KREMMER E,et al.Follicular B helper Tcells express CXC chemokine receptor 5,localize to B cell follicles,and support immunoglobulin production[J].J Exp Med,2000,192(11):1545-1552.
|
[2] SCHAERLI P,WILLIMANN K,LANG AB,et al.CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function[J].J Exp Med,2000,192(11):1553-1562.
|
[3]VINUESA CG,COOK MC.Blood relatives of follicular helper Tcells[J].Immunity,2011,34(1):10-12.
|
[4] ARROYO-VILLA I,BAUTISTA-CARO MB,BALSA A,et al.Constitutively altered frequencies of circulating follicular helper Tcell counterparts and their subsets in rheumatoid arthritis[J].Arthritis Res Ther,2014,16(6):500.
|
[5]SCHMITT N,BENTEBIBEL SE,UENO H.Phenotype and functions of memory TFH cells in human blood[J].Trends Immunol,2014,35(9):436-442.
|
[6]MORITA R,SCHMITTN,BENTEBIBEL,et al.Human blood CX-CR5(+)CD4(+)T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion[J].Immunity,2011,34(1):108-121.
|
[7] SILVER JS,HUNTER CA.With a little help from their friends:interleukin-21,T cells,and B cells[J].Immunity,2008,29(1):7-9.
|
[8]NURIEVA RI,CHUNG Y,HWANG D,et al.Generation of Tfollicular helper cells is mediated by IL-21 but independent of Thelper 1,2,or 17 cell lineages[J].Immunity,2008,29(1):138-149.
|
[9] KAUFMANN DE,WALKER BD.PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention[J].J Immunol,2009,182(10):5891-5897.
|
[10]HAYMAKER C,WU R,BERNATCHEZ C,et al.PD-1 and BT-LA and CD8(+)T-cell exhaustion in cancer:exercising an alternative viewpoint[J].Oncoimmunology,2012,1(5):735-738.
|
[11] NURIEVA RI,CHUNG Y.Understanding the development and function of T follicular helper cells[J].Cell Mol Immunol,2010,7(3):190-197.
|
[12] NANCE JP,BELANGER S,JOHNSTON RJ,et al.Cutting edge:Tfollicular helper cell differentiation is defective in the absence of Bcl6BTB repressor domain function[J].J Immunol,2015,194(12):5599-5603.
|
[13] YANG JA,TUBO NJ,GEARHART MD,et al.Cutting edge:Bcl6-interacting corepressor contributes to germinal center T follicular helper cell formation and B Cell helper function[J].J Immunol,2015,194(12):5604-5608.
|
[14]LINDQVIST M,VAN LUNZEN J,SOGHOIAN DZ,et al.Expansion of HIV-specific T follicular helper cells in chronic HIV infection[J].J Clin Invest,2012,122(9):3271-3280.
|
[15] WU H,XU LL,TEUSCHER P,et al.An inhibitory role for the transcription factor stat3 in controlling IL-4 and Bcl6 expression in follicular helper T cells[J].J Immunol,2015,195(5):2080-2089.
|
[16] LIN X,CHEN X,ZHONG B,et al.Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development[J].Nature,2014,507(7493):513-518.
|
[17] JOHNSTON RJ,POHOLEK AC,DITORO D,et al.Bcl-6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation[J].Science,2009,325(5943):1006-1010.
|
[18]LAURENCE A,TATO CM,DAVIDSON TS,et al.Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation[J].Immunity,2007,26(3):371-381.
|
[19]GODEFROY E,ZHONG H,PHAM P,et al.TIGIT-positive circulating follicular helper T cells display robust B cell help functions:potential role in sickle cell alloimmunization[J].Haematologica,2015,100(11):1415-1425.
|
[20]MA W,ZHAO R,YANG R,et al.Nuclear receptors of the NR4a family are not required for the development and function of follicular T helper cells[J].Int Immunopharmacol,2015,28(2):841-845.
|
[21] SEO YB,IM SJ,NAMKOONG H,et al.Crucial Roles of Interleukin-7 in the development of T follicular helper cells and in the induction of humoral immunity[J].J Virol,2014,88(16):8998-9009.
|
[22] Mc DONALD PW,READ KA,BAKER CE,et al.IL-7 signalling represses Bcl-6 and the TFH gene program[J].Nat Commun,2016.doi: 10.1038/ncomms10285.
|
[23] ZHAO PW,SHI X,LI C,et al.IL-33 Enhances Humoral Immunity Against Chronic HBV Infection Through Activating CD4+CX-CR5+TFH Cells[J].J Interferon Cytokine Res,2015,35(6):454-463.
|
[24] BATTEN M,RAMAMOORTHI N,KLJAVIN NM,et al.IL-27supports germinal center function by enhancing Il-21 production and the function of T follicular helper cells[J].J Exp Med,2010,207(13):2895-2906.
|
[25] REINHARTS RL,LIANG HE,LOCKSLEY RM.Cytokine-secreting follicular T cells shape the antibody repertoire[J].Nat Immunol,2009,10(4):385-393.
|
[26] CROTTY S,JOHNSTON RJ,SCHOENBERGER SP.Effectors and memories:Bcl-6 and Blimp-1 in T and B lymphocyte differentiation[J].Nat Immunol,2010,11(2):114-120.
|
[27] GLATMAN ZARETSKY A,TAYLOR JJ,KING IL,et al.T follicular helper cells differentiate from Th2 cells in response to helminth antigens[J].J Exp Med,2009,206(5):991-999.
|
[28]CROTTY S.Follicular helper CD4 T cells(TFH)[J].Annu Rev Immunol,2011,29:621-663.
|
[29]VINUESA CG,CYSTER JG.How T cells earn the follicular rite of passage[J].Immunity,2011,35(5):671-680.
|
[30] KROENKE MA,ETO D,LOCCI M,et al.Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation[J].JImmunol,2012,188(8):3734-3744.
|
[31]TAKEMORI T,KAJI T,TAKAHASHI Y,et al.Generation of memory B cells inside and outside germinal centers[J].Eur J Immunol,2014,44(5):1258-1264.
|
[32] FENG J,LU L,HUA C,et al.High frequency of CD4+CXCR5+TFH cells in patients with immune-active chronic hepatitis B[J].PLo S One,2011,6(7):e21698.
|
[33]MA ZY,XIE YM,WANG Y,et al.Peripheral blood CD4+CX-CR5+follicular helper T cells are related to hyperglobulinemia of patients with chronic hepatitis B[J].Chin J Cell Mol Immunol,2013,29(5):515-521.(in Chinese)马志远,谢玉梅,王宇,等.外周血CD4+CXCR5+滤泡辅助性T细胞与慢性乙型肝炎患者高球蛋白血症相关[J].细胞与分子免疫学杂志,2013,29(5):515-521.
|
[34]LI Y,MA S,TANG L,et al.Circulating chemokine(C-X-CMotif)receptor 5(+)CD4(+)T cells benefit hepatitis B e antigen seroconversion through IL-21 in patients with chronic hepatitis Bvirus infection[J].Hepatology,2013,58(4):1277-1286.
|
[35]HUANG CY,DENG H,ZHU JY,et al.Dynamic changes of circulating TFH cells during antiviral therapy in chronic hepatitis B patients[J].Chin J Pathophysiol,2014,30(2):297-301.(in Chinese)黄春燕,邓洪,朱建芸,等.慢性乙型肝炎患者抗病毒治疗前后体内TFH细胞的动态变化[J].中国病理生理杂志,2014,30(2):297-301.
|
[36] GU XB,YANG XJ,WANG JH,et al.Relationship between HBVgenotypes B,C and follicular helper T cells in patients with chronic hepatitis B and its significance[J].Hepat Mon,2013,13(1):e6221.
|
[37]FENG JY,HU XL,GUO H,et al.Patients with chronic hepatitis C express a high percentage of CD4(+)CXCR5(+)T follicular helper cells[J].J Gastroenterol,2012,47(9):1048-1056.
|
[38]SPAAN M,KREEFFT K,de GRAAV GN,et al.CD4+CXCR5+Tcells in chronic HCV infection produce less IL-21,yet are efficient at supporting B cell responses[J].J Hepatol,2015,62(2):303-310.
|
[39] TRIPODO C,PETTA S,GUARNOTTA C,et al.Liver follicular helper T cells predict the achievement of virological response following interferson-based treatment in HCV-infected patients[J].Antivir Ther,2012,17(1):111-118.
|
[40]LIU LZ,WANG J,LEI Y,et al.Preliminary study of the T follicular helper cells and interleukin-21 in patients with autoimmune hepatitis[J].Immunol J,2010,26(12):1065-1069.(in Chinese)刘良忠,王静,雷宇,等.循环滤泡型辅助性T淋巴细胞及IL-21在自身免疫性肝炎中的初步研究[J].免疫学杂志,2010,26(12):1065-1069.
|
[41]AOKI N,KIDO M,IWAMOTO S,et al.Dysregulated generation of follicular helper T cells in the spleen triggers fatal autoimmune hepatitis in mice[J].Gastroenterology,2011,140(4):1322-1333.
|
[42]WANG L,SUN XG,QIU JP,et al.Increased numbers of circulating ICOS+follicular helper T and CD38+Plasma cells in patients with newly diagnosed primary biliary cirrhosis[J].Dig Dis Sci,2015,60(2):405-413.
|
[43]WANG LF,SUN Y,ZHANG Z,et al.CXCR5+CD4+T follicular helper cells participate in the pathogenesis of primary biliary cirrhosis[J].Hepatology,2015,61(2):627-638.
|
[44]CAI W.Role and regulation of follicular helper T cells in hepatitis B patients with acute-on-chronic liver failure[R].The 13th National Conference on Infectious Diseases,Chinese Medical Association,2014.(in Chinese)蔡伟.滤泡辅助性T细胞在乙肝相关慢加急性肝衰竭患者中的作用及调控研究[R].中华医学会第十三次全国感染病学术会议,2014.
|
[45]LOU B.Predictive value of follicular helper T cells in recurrence of HBV infection in patients after liver transplantation[R].Zhejiang Academic Annual Conference on Laboratory Medicine,2014.(in Chinese)楼滨.滤泡辅助性T细胞对于预测肝移植病人术后HBV感染复发相关性的探讨[R].浙江省检验医学学术年会,2014.
|