中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2016
Turn off MathJax
Article Contents

Role of follicular helper T cells in development and progression of liver diseases

DOI: 10.3969/j.issn.1001-5256.2016.06.050
Research funding:

 

  • Published Date: 2016-06-20
  • Follicular helper T cell(TFH) is a new CD4+T lymphocyte subset which helps B lymphocytes to produce antibodies and is closely related to the development and progression of liver diseases.This article reviews the detection and differentiation of TFH and related functional molecules,the mechanism of action of TFH in helping B lymphocytes to produce antibodies through producing interleukin- 21,as well as the role of TFH in liver diseases such as chronic hepatitis B,chronic hepatitis C,autoimmune hepatitis,primary biliary cirrhosis,hepatic failure,and liver transplantation,and points out that TFH may become the new target cell in the treatment of liver diseases.

     

  • loading
  • [1] BREITFELD D,OHL L,KREMMER E,et al.Follicular B helper Tcells express CXC chemokine receptor 5,localize to B cell follicles,and support immunoglobulin production[J].J Exp Med,2000,192(11):1545-1552.
    [2] SCHAERLI P,WILLIMANN K,LANG AB,et al.CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function[J].J Exp Med,2000,192(11):1553-1562.
    [3]VINUESA CG,COOK MC.Blood relatives of follicular helper Tcells[J].Immunity,2011,34(1):10-12.
    [4] ARROYO-VILLA I,BAUTISTA-CARO MB,BALSA A,et al.Constitutively altered frequencies of circulating follicular helper Tcell counterparts and their subsets in rheumatoid arthritis[J].Arthritis Res Ther,2014,16(6):500.
    [5]SCHMITT N,BENTEBIBEL SE,UENO H.Phenotype and functions of memory TFH cells in human blood[J].Trends Immunol,2014,35(9):436-442.
    [6]MORITA R,SCHMITTN,BENTEBIBEL,et al.Human blood CX-CR5(+)CD4(+)T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion[J].Immunity,2011,34(1):108-121.
    [7] SILVER JS,HUNTER CA.With a little help from their friends:interleukin-21,T cells,and B cells[J].Immunity,2008,29(1):7-9.
    [8]NURIEVA RI,CHUNG Y,HWANG D,et al.Generation of Tfollicular helper cells is mediated by IL-21 but independent of Thelper 1,2,or 17 cell lineages[J].Immunity,2008,29(1):138-149.
    [9] KAUFMANN DE,WALKER BD.PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention[J].J Immunol,2009,182(10):5891-5897.
    [10]HAYMAKER C,WU R,BERNATCHEZ C,et al.PD-1 and BT-LA and CD8(+)T-cell exhaustion in cancer:exercising an alternative viewpoint[J].Oncoimmunology,2012,1(5):735-738.
    [11] NURIEVA RI,CHUNG Y.Understanding the development and function of T follicular helper cells[J].Cell Mol Immunol,2010,7(3):190-197.
    [12] NANCE JP,BELANGER S,JOHNSTON RJ,et al.Cutting edge:Tfollicular helper cell differentiation is defective in the absence of Bcl6BTB repressor domain function[J].J Immunol,2015,194(12):5599-5603.
    [13] YANG JA,TUBO NJ,GEARHART MD,et al.Cutting edge:Bcl6-interacting corepressor contributes to germinal center T follicular helper cell formation and B Cell helper function[J].J Immunol,2015,194(12):5604-5608.
    [14]LINDQVIST M,VAN LUNZEN J,SOGHOIAN DZ,et al.Expansion of HIV-specific T follicular helper cells in chronic HIV infection[J].J Clin Invest,2012,122(9):3271-3280.
    [15] WU H,XU LL,TEUSCHER P,et al.An inhibitory role for the transcription factor stat3 in controlling IL-4 and Bcl6 expression in follicular helper T cells[J].J Immunol,2015,195(5):2080-2089.
    [16] LIN X,CHEN X,ZHONG B,et al.Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development[J].Nature,2014,507(7493):513-518.
    [17] JOHNSTON RJ,POHOLEK AC,DITORO D,et al.Bcl-6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation[J].Science,2009,325(5943):1006-1010.
    [18]LAURENCE A,TATO CM,DAVIDSON TS,et al.Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation[J].Immunity,2007,26(3):371-381.
    [19]GODEFROY E,ZHONG H,PHAM P,et al.TIGIT-positive circulating follicular helper T cells display robust B cell help functions:potential role in sickle cell alloimmunization[J].Haematologica,2015,100(11):1415-1425.
    [20]MA W,ZHAO R,YANG R,et al.Nuclear receptors of the NR4a family are not required for the development and function of follicular T helper cells[J].Int Immunopharmacol,2015,28(2):841-845.
    [21] SEO YB,IM SJ,NAMKOONG H,et al.Crucial Roles of Interleukin-7 in the development of T follicular helper cells and in the induction of humoral immunity[J].J Virol,2014,88(16):8998-9009.
    [22] Mc DONALD PW,READ KA,BAKER CE,et al.IL-7 signalling represses Bcl-6 and the TFH gene program[J].Nat Commun,2016.doi: 10.1038/ncomms10285.
    [23] ZHAO PW,SHI X,LI C,et al.IL-33 Enhances Humoral Immunity Against Chronic HBV Infection Through Activating CD4+CX-CR5+TFH Cells[J].J Interferon Cytokine Res,2015,35(6):454-463.
    [24] BATTEN M,RAMAMOORTHI N,KLJAVIN NM,et al.IL-27supports germinal center function by enhancing Il-21 production and the function of T follicular helper cells[J].J Exp Med,2010,207(13):2895-2906.
    [25] REINHARTS RL,LIANG HE,LOCKSLEY RM.Cytokine-secreting follicular T cells shape the antibody repertoire[J].Nat Immunol,2009,10(4):385-393.
    [26] CROTTY S,JOHNSTON RJ,SCHOENBERGER SP.Effectors and memories:Bcl-6 and Blimp-1 in T and B lymphocyte differentiation[J].Nat Immunol,2010,11(2):114-120.
    [27] GLATMAN ZARETSKY A,TAYLOR JJ,KING IL,et al.T follicular helper cells differentiate from Th2 cells in response to helminth antigens[J].J Exp Med,2009,206(5):991-999.
    [28]CROTTY S.Follicular helper CD4 T cells(TFH)[J].Annu Rev Immunol,2011,29:621-663.
    [29]VINUESA CG,CYSTER JG.How T cells earn the follicular rite of passage[J].Immunity,2011,35(5):671-680.
    [30] KROENKE MA,ETO D,LOCCI M,et al.Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation[J].JImmunol,2012,188(8):3734-3744.
    [31]TAKEMORI T,KAJI T,TAKAHASHI Y,et al.Generation of memory B cells inside and outside germinal centers[J].Eur J Immunol,2014,44(5):1258-1264.
    [32] FENG J,LU L,HUA C,et al.High frequency of CD4+CXCR5+TFH cells in patients with immune-active chronic hepatitis B[J].PLo S One,2011,6(7):e21698.
    [33]MA ZY,XIE YM,WANG Y,et al.Peripheral blood CD4+CX-CR5+follicular helper T cells are related to hyperglobulinemia of patients with chronic hepatitis B[J].Chin J Cell Mol Immunol,2013,29(5):515-521.(in Chinese)马志远,谢玉梅,王宇,等.外周血CD4+CXCR5+滤泡辅助性T细胞与慢性乙型肝炎患者高球蛋白血症相关[J].细胞与分子免疫学杂志,2013,29(5):515-521.
    [34]LI Y,MA S,TANG L,et al.Circulating chemokine(C-X-CMotif)receptor 5(+)CD4(+)T cells benefit hepatitis B e antigen seroconversion through IL-21 in patients with chronic hepatitis Bvirus infection[J].Hepatology,2013,58(4):1277-1286.
    [35]HUANG CY,DENG H,ZHU JY,et al.Dynamic changes of circulating TFH cells during antiviral therapy in chronic hepatitis B patients[J].Chin J Pathophysiol,2014,30(2):297-301.(in Chinese)黄春燕,邓洪,朱建芸,等.慢性乙型肝炎患者抗病毒治疗前后体内TFH细胞的动态变化[J].中国病理生理杂志,2014,30(2):297-301.
    [36] GU XB,YANG XJ,WANG JH,et al.Relationship between HBVgenotypes B,C and follicular helper T cells in patients with chronic hepatitis B and its significance[J].Hepat Mon,2013,13(1):e6221.
    [37]FENG JY,HU XL,GUO H,et al.Patients with chronic hepatitis C express a high percentage of CD4(+)CXCR5(+)T follicular helper cells[J].J Gastroenterol,2012,47(9):1048-1056.
    [38]SPAAN M,KREEFFT K,de GRAAV GN,et al.CD4+CXCR5+Tcells in chronic HCV infection produce less IL-21,yet are efficient at supporting B cell responses[J].J Hepatol,2015,62(2):303-310.
    [39] TRIPODO C,PETTA S,GUARNOTTA C,et al.Liver follicular helper T cells predict the achievement of virological response following interferson-based treatment in HCV-infected patients[J].Antivir Ther,2012,17(1):111-118.
    [40]LIU LZ,WANG J,LEI Y,et al.Preliminary study of the T follicular helper cells and interleukin-21 in patients with autoimmune hepatitis[J].Immunol J,2010,26(12):1065-1069.(in Chinese)刘良忠,王静,雷宇,等.循环滤泡型辅助性T淋巴细胞及IL-21在自身免疫性肝炎中的初步研究[J].免疫学杂志,2010,26(12):1065-1069.
    [41]AOKI N,KIDO M,IWAMOTO S,et al.Dysregulated generation of follicular helper T cells in the spleen triggers fatal autoimmune hepatitis in mice[J].Gastroenterology,2011,140(4):1322-1333.
    [42]WANG L,SUN XG,QIU JP,et al.Increased numbers of circulating ICOS+follicular helper T and CD38+Plasma cells in patients with newly diagnosed primary biliary cirrhosis[J].Dig Dis Sci,2015,60(2):405-413.
    [43]WANG LF,SUN Y,ZHANG Z,et al.CXCR5+CD4+T follicular helper cells participate in the pathogenesis of primary biliary cirrhosis[J].Hepatology,2015,61(2):627-638.
    [44]CAI W.Role and regulation of follicular helper T cells in hepatitis B patients with acute-on-chronic liver failure[R].The 13th National Conference on Infectious Diseases,Chinese Medical Association,2014.(in Chinese)蔡伟.滤泡辅助性T细胞在乙肝相关慢加急性肝衰竭患者中的作用及调控研究[R].中华医学会第十三次全国感染病学术会议,2014.
    [45]LOU B.Predictive value of follicular helper T cells in recurrence of HBV infection in patients after liver transplantation[R].Zhejiang Academic Annual Conference on Laboratory Medicine,2014.(in Chinese)楼滨.滤泡辅助性T细胞对于预测肝移植病人术后HBV感染复发相关性的探讨[R].浙江省检验医学学术年会,2014.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1565) PDF downloads(433) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return