中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 8
Aug.  2016
Turn off MathJax
Article Contents

Research advances in radiological examination for nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2016.08.009
  • Received Date: 2016-06-02
  • Published Date: 2016-08-20
  • There is a high prevalence of nonalcoholic fatty liver disease( NAFLD) around the world,and early diagnosis and evaluation of liver fatty degeneration and fibrosis degree play important roles in the early treatment and prognostic evaluation of patients with NAFLD. This article reviews the principles,diagnostic accuracy,influencing factors,and practicability of various imaging techniques applied in liver fat quantification and fibrosis prediction. Studies have shown that radiological fat quantitative diagnosis based on ultrasound and magnetic resonance and liver fibrosis evaluation based on elastography have a high level of accuracy and promising prospects; however,such techniques lack standard cut- off values and operating procedures which may provide a reference for clinical application.

     

  • loading
  • [1]HAAS JT,FRANCQUE S,STAELS B.Pathophysiology and mechanisms of nonalcoholic fatty liver disease[J].Annu Rev Physiol,2016,78(1):181-205.
    [2]YOUNOSSI ZM,KOENIG AB,ABDELATIF D,et al.Global epidemiology of non-alcoholic fatty liver disease-meta-analytic assessment of prevalence,incidence and outcomes[J].Hepatology,2016,64(1):73-84.
    [3]ZHANG F,HUANG YQ,BAO ZJ.Prevalence of nonalcoholic fatty liver disease in urban areas in China[J].Chin J Dig,2014,34(6):430-432.(in Chinese)张帆,黄一沁,保志军.非酒精性脂肪性肝病在我国城市地区的流行现状[J].中华消化杂志,2014,34(6):430-432.
    [4]LIAO XH,CAO X,LIU J,et al.Prevalence and features of fatty liver detected by physical examination in Guangzhou[J].World JGastroenterol,2013,19(32):5334-5339.
    [5]ANGULO P,KLEINER DE,DAM-LARSEN S,et al.Liver fibrosis,but no other histologic features,is associated with long-term outcomes of patients with nonalcoholic fatty liver disease[J].Gastroenterology,2015,149(2):389-397.
    [6]EKSTEDT M,HAGSTROM H,NASR P,et al.Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up[J].Hepatology,2015,61(5):1547-1554.
    [7]BEDOSSA P,PATEL K.Biopsy and noninvasive methods to assess progression of nonalcoholic fatty liver disease[J].Gastroenterology,2016,150(8):1811-1822.e4.
    [8]SHI KQ,TANG JZ,ZHU XL,et al.Controlled attenuation parameter for the detection of steatosis severity in chronic liver disease:a meta-analysis of diagnostic accuracy[J].J Gastroenterol Hepatol,2014,29(6):1149-1158.
    [9]BERZIGOTTI A.Getting closer to a point-of-care diagnostic assessment in patients with chronic liver disease:controlled attenuation parameter for steatosis[J].J Hepatol,2014,60(5):910-912.
    [10]LEDINGHEN V,WONG G L,VERGNIOL J,et al.Controlled attenuation parameter for the diagnosis of steatosis in non-alcoholic fatty liver disease[J].J Gastroenterol Hepatol,2016,31(4):848-855.
    [11]SON JY,LEE JY,YI NJ,et al.Hepatic steatosis:assessment with acoustic structure quantification of us imaging[J].Radiology,2016,278(1):257-264.
    [12]ZHANG B,DING F,CHEN T,et al.Ultrasound hepatic/renal ratio and hepatic attenuation rate for quantifying liver fat content[J].World J Gastroenterol,2014,20(47):17985-17992.
    [13]VUPPALANCHI R,CUMMINGS OW,SAXENA R,et al.Relationship among histologic,radiologic,and biochemical assessments of hepatic steatosis:a study of human liver samples[J].J Clin Gastroenterol,2007,41(2):206-210.
    [14]LE TA,CHEN J,CHANGCHIEN C,et al.Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis:a randomized controlled trial[J].Hepatology,2012,56(3):922-932.
    [15]NOUREDDIN M,LAM J,PETERSON MR,et al.Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials[J].Hepatology,2013,58(6):1930-1940.
    [16]MEISAMY S,HINES CD,HAMILTON G,et al.Quantification of hepatic steatosis with T1-independent,T2-corrected MR imaging with spectral modeling of fat:blinded comparison with MR spectroscopy[J].Radiology,2011,258(3):767-775.
    [17]IDILMAN I S,ANIKTAR H,IDILMAN R,et al.Hepatic steatosis:quantification by proton density fat fraction with MR imaging versus liver biopsy[J].Radiology,2013,267(3):767-775.
    [18]TANG A,DESAI A,HAMILTON G,et al.Accuracy of MR imaging-estimated proton density fat fraction for classification of dichotomized histologic steatosis grades in nonalcoholic fatty liver disease[J].Radiology,2015,274(2):416-425.
    [19]BANNAS P,KRAMER H,HERNANDO D,et al.Quantitative magnetic resonance imaging of hepatic steatosis:validation in ex vivo human livers[J].Hepatology,2015,62(5):1444-1455.
    [20]SOLIMAN AS,YUAN J,VIGEN KK,et al.Max-IDEAL:a max-flow based approach for IDEAL water/fat separation[J].Magn Reson Med,2014,72(2):510-521.
    [21]HU HH,KIM HW,NAYAK KS,et al.Comparison of fat-water MRI and single-voxel MRS in the assessment of hepatic and pancreatic fat fractions in humans[J].Obesity(Silver Spring),2010,18(4):841-847.
    [22]IDILMAN IS,TUZUN A,SAVAS B,et al.Quantification of liver,pancreas,kidney,and vertebral body MRI-PDFF in non-alcoholic fatty liver disease[J].Abdom Imaging,2015,40(6):1512-1519.
    [23]KWOK R,TSE YK,WONG GL,et al.Systematic review with metaanalysis:non-invasive assessment of non-alcoholic fatty liver disease-the role of transient elastography and plasma cytokeratin-18 fragments[J].Aliment Pharmacol Ther,2014,39(3):254-269.
    [24]MAHADEVA S,MAHFUDZ AS,VIJAYANATHAN A,et al.Performance of transient elastography(TE)and factors associated with discordance in non-alcoholic fatty liver disease[J].J Dig Dis,2013,14(11):604-610.
    [25]WONG VW,VERGNIOL J,WONG GL,et al.Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease[J].Hepatology,2010,51(2):454-462.
    [26]TAPPER EB,CHALLIES T,NASSER I,et al.The performance of vibration controlled transient elastography in a us cohort of patients with nonalcoholic fatty liver disease[J].Am J Gastroenterol,2016,111(5):677-684.
    [27]de LEDINGHEN V,WONG VW,VERGNIOL J,et al.Diagnosis of liver fibrosis and cirrhosis using liver stiffness measurement:comparison between M and XL probe of FibroS can(R)[J].J Hepatol,2012,56(4):833-839.
    [28]MYERS RP,POMIER-LAYRARGUES G,KIRSCH R,et al.Feasibility and diagnostic performance of the FibroS can XL probe for liver stiffness measurement in overweight and obese patients[J].Hepatology,2012,55(1):199-208.
    [29]WONG VW,VERGNIOL J,WONG GL,et al.Liver stiffness measurement using XL probe in patients with nonalcoholic fatty liver disease[J].Am J Gastroenterol,2012,107(12):1862-1871.
    [30]LIU H,FU J,HONG R,et al.Acoustic radiation force impulse elastography for the non-invasive evaluation of hepatic fibrosis in non-alcoholic fatty liver disease patients:a systematic review&Meta-analysis[J].PLoS One,2015,10(7):e127782.
    [31]FRIEDRICH-RUST M,ROMEN D,VERMEHREN J,et al.A-coustic radiation force impulse-imaging and transient elastography for non-invasive assessment of liver fibrosis and steatosis in NAFLD[J].Eur J Radiol,2012,81(3):e325-e331.
    [32]SINGH S,VENKATESH SK,LOOMBA R,et al.Magnetic resonance elastography for staging liver fibrosis in non-alcoholic fatty liver disease:a diagnostic accuracy systematic review and individual participant data pooled analysis[J].Eur Radiol,2016,26(5):1431-1440.
    [33]IMAJO K,KESSOKU T,HONDA Y,et al.Magnetic resonance imaging more accurately classifies steatosis and fibrosis in patients with nonalcoholic fatty liver disease Than Transient Elastography[J].Gastroenterology,2016,150(3):626-637.
    [34]CUI J,HEBA E,HERNANDEZ C,et al.Magnetic resonance elastography is superior to acoustic radiation force impulse for the diagnosis of fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease:a prospective study[J].Hepatology,2016,63(2):453-461.
    [35]LOOMBA R,CUI J,WOLFSON T,et al.Novel 3D magnetic resonance elastography for the noninvasive diagnosis of advanced fibrosis in nafld:a prospective study[J].Am J Gastroenterol,2016,111(7):986-994.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2319) PDF downloads(490) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return