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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 8
Aug.  2016
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Article Contents

Regulatory effect of interleukin-10 on natural killer cells in patients with chronic hepatitis B

DOI: 10.3969/j.issn.1001-5256.2016.08.040
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  • Received Date: 2016-06-07
  • Published Date: 2016-08-20
  • At present,it is very difficult to cure chronic hepatitis B( CHB) with current therapeutic methods. Natural killer( NK) cells are an important part of innate immunity and play an important role in immune surveillance and early anti- infectious immune process. Interleukin- 10( IL- 10) is a multifunctional negative regulatory factor and is involved in the biological regulation of immune cells and inflammatory cells. This article introduces the features and functions of IL- 10 and NK cells,the association of CHB with IL- 10 and NK cells,and the value of IL- 10 and NK cells in the treatment of CHB,and points out that in CHB,IL- 10 exerts a negative regulatory effect on NK cells. Further investigations are needed to confirm whether the antiviral function of NK cells can be enhanced through blocking the regulatory effect of IL- 10 on NK cells,and whether liver immunopathology induced by activation of NK cells can be avoided at the same time.

     

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