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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 8
Aug.  2016
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Article Contents

Role of intestinal flora in the development and progression of spontaneous bacterial peritonitis

DOI: 10.3969/j.issn.1001-5256.2016.08.045
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  • Received Date: 2016-03-23
  • Published Date: 2016-08-20
  • Spontaneous bacterial peritonitis( SBP) is a major complication of liver cirrhosis. In recent years,with the development of biotechnology,such as high- throughput sequencing and intestinal metagenomics,the role of intestinal flora in liver diseases has been taken more and more seriously. Bacterial translocation,especially the translocation of Gram- negative enteric bacilli,is involved in the development and progression of SBP. This article briefly describes the factors related to the development and progression of SBP and the important role of intestinal flora in SBP. The improvement in biotechnology clarifies the role of intestinal flora in diseases,and restoration of balanced intestinal flora may become a new method for the prevention and treatment of SBP.

     

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  • [1]SCHIFF ER,SORRELL MR.Schiff’s Diseases of the liver[M].Beijing:Chemical Industry Press,2006:519.(in Chinese)尤金R.希夫,迈克尔F.索雷尔.希夫肝脏病学[M].北京:化学工业出版社,2006:519.
    [2]WIEST R,GARCIA-TSAO G.Bacterial translocation(BT)in cirrhosis[J].Hepatology,2005,41(3):422-433.
    [3]NOLAN JP.The role of intestinal endotoxin in liver injury:a long and evolving history[J].Hepatology,2010,52(5):1829-1835.
    [4]GILL SR,POP M,DEBOY RT,et al.Metagenomic analysis of the human distal gut microbiome[J].Science,2006,312(5778):1355-1359.
    [5]WIEST R,KRAG A,GERBES A.Spontaneous bacterial peritonitis:recent guidelines and beyond[J].Gut,2012,61(2):297-310.
    [6]BENTEN D,WIEST R.Gut microbiome and intestinal barrier failure-the“Achilles heel”in hepatology?[J].J Hepatol,2012,56(6):1221-1223.
    [7]SUCH J,FRANCES R,MUNOZ C,et al.Detection and identification of bacterial DNA in patients with cirrhosis and culture-negative,nonneutrocytic ascites[J].Hepatology,2002,36(1):135-141.
    [8]ALBILLOS A,de la HERA A,GONZALES M,et al.Increased lipopolysaccharide binding protein in cirrhotic patients with marked immune and hemodynamic derangement[J].Hepatology,2003,37(1):208-217.
    [9]KOUTSOUNAS I,KALTSA G,SIAKAVELLAS SI,et al.Markers of bacterial translocation in end-stage liver disease[J].World J Hepatol,2015,7(20):2264-2273.
    [10]BAUER TM,STEINBRCKNER B,BRINKMANN FE,et al.Small intestinal bacterial overgrowth in patients with cirrhosis:prevalence and relafion with spontaneous bacterial peritonitis[J].Am J Gastroenterol,2001,96(10):2962-2967.
    [11]ROGERS GB,van der GAST CJ,BRUCE KD,et al.Ascitic microbiota composition is correlated with clinical severity in cirrhosis withportalhypertension[J].PLo S One,2013,8(9):e74884.
    [12]QIN N,YANG F,LI A,et al.Alterations of the human gut microbiome in liver cirrhosis[J].Nature,2014,513(7516):59-64.
    [13]WANG JH,CHEN MH,SUN GY,et al.Small bowel bacterial overgrowth and endotoxemia in cirrhosis[J].Chin J Inter Med,2002,41(7):459-461.(in Chinese)王锦辉,陈旻湖,孙光裕,等.肝硬化患者小肠细菌过度生长与内毒素血症[J].中华内科杂志,2002,41(7):459-461.
    [14]WEN JB,ZHU FQ,CHEN WG,et al.Oxymatrine improves intestinal epithelial barrier function involving NF-κB-mediated signaling pathway in CCl4-induced cirrhotic rats[J].PLo S One,2014,9(8):e106082.
    [15]CEREIJIDO M,CONTRERAS RG,FLORES-BENTEZ D,et al.New diseases derived or associated with the tight junction[J].Arch Med Res,2007,38(5):465-478.
    [16]SONODA N,FURUSE M,SASAKI H,et al.Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands:evidence for direct involvement of claudins in tight junction barrier[J].J Cell Biol,1999,147(1):195-204.
    [17]ASSIMAKOPOULOS SF,TSAMANDAS AC,TSIAOUSSIS GI,et al.Altered intestinal tight junctions'expression in patients with liver cirrhosis:a pathogenetic mechanism of intestinalhyperpermeability[J].Eur J Clin Invest,2012,42(4):439-446.
    [18]CHANDER ROLAND B,GARCIA-TSAO G,CIARLEGLIO MM,et al.Decompensated cirrhotics have slower intestinal transit times as compared with compensated cirrhotics and healthy controls[J].J Clin Gastroenterol,2013,47(10):888-893.
    [19]PREZ-PARAMO M,MUOZ J,ALBILLOS A,et al.Effect of propranolol on the factors promoting bacterial translocation in cirrhotic rats with ascites[J].Hepatology,2000,31(1):43-48.
    [20]MANDORFER M,BOTA S,SCHWABL P,et al.Nonselectiveβblockers increase risk for hepatorenal syndrome and death in patients with cirrhosis and spontaneous bacterial peritonitis[J].Gastroenterology,2014,146(7):1680-1690.
    [21]ZHANG SC,WANG W,REN WY,et al.Effect of cisapride on intestinal bacterial and endotoxin translocation in cirrhosis[J].World J Gastroenterol,2003,9(3):534-538.
    [22] CASAFONT F,SNCHEZ E,MARTN L,et al.Influence of malnutrition on the prevalence of bacterial translocation and spontaneous bacterial peritonitis in experimental cirrhosis in rats[J].Hepatology,1997,25(6):1334-1337.
    [23]HODIN CM,LENAERTS K,GROOTJANS J,et al.Starvation compromises Paneth cells[J].Am J Pathol,2011,179(6):2885-2893.
    [24]DANULESCU RSM,ALIN C,CAROL S,et al.The relevance of oxidative stress balance(Superoxide dismutase versus malondialdehyde)in spontaneous bacterial peritonitis[J].Arch Biol Sci,2014,66(2):793-799.
    [25]APPENRODT B,GRNHAGE F,GENTEMANN MG,et al.Nucleotide-binding oligomerization domain containing 2(NOD2)variants are genetic risk factors for death and spontaneous bacterial peritonitis in liver cirrhosis[J].Hepatology,2010,51(4):1327-1333.
    [26]BRUNS T,PETER J,REUKEN PA,et al.NOD2 gene variants are a risk factor for culture-positive spontaneous bacterial peritonitis and monomicrobialbacterascites in cirrhosis[J].Liver Int,2012,32(2):223-230.
    [27]SNCHEZ E,NIETO JC,BOULLOSA A,et al.VSL#3 probiotic treatment decreases bacterial translocation in rats with carbon tetrachloride-induced cirrhosis[J].Liver Int,2015,35(3):735-745.
    [28]MORATALLA A,GMEZ-HURTADO I,MOYA-PREZ,et al.Bifidobacterium pseudocatenulatum CECT7765 promotes a TLR2-dependent anti-inflammatory response in intestinal lymphocytes from mice with cirrhosis[J].Eur J Nutr,2016,55(1):197-206.
    [29]GUPTA N,KUMAR A,SHARMA P.Effects of the adjunctive probiotic VSL#3 on portal haemodynamics inpatients with cirrhosis and large varices:a randomized trial[J].Liver Int,2013,33(8):1148-1157.
    [30]HUANG XY,LI GP,KOU JG,et al.Relationship between intestinal dysbacteriosis and Child-Pugh classification in patients with cirrhosis[J].J Clin Hepatol,2015,31(3):392-395.(in Chinese)黄晓宇,李刚平,寇继光,等.肝硬化患者肠道菌群失调与Child-Pugh分级的关系[J].临床肝胆病杂志,2015,31(3):392-395.
    [31]WANG WF,CAO JB,XIONG JH,et al.Effect of probiotics in improvement of minimal hepatic encephalopathy in cirrhosis patients with hepatitis B virus[J].Med&Pharm J Chin PLA,2015,27(2):17-19.(in Chinese)王伟芳,曹建彪,熊锦华,等.益生菌在乙型肝炎肝硬化患者轻微肝性脑病中的应用效果[J].解放军医药杂志,2015,27(2):17-19
    [32]ZHANG MM,FANG T,ZHANG J,et al.Efficacy of probiotics in treating liver cirrhosis:a meta analysis[J].Chin J Gastroenterol,2014,19(1):25-31.(in Chinese)张明明,方田,张静,等.益生菌制剂治疗肝硬化的meta分析[J].胃肠病学,2014,19(1):25-31.
    [33] YANG JY,QU JM,HU XJ.Effect of traditional Chinese medicine on bacterial localization and translocation[M]//LI LJ.Infectious Microecology.Beijing:People's Medical Publishing House,2012:66.(in Chinese)杨景云,瞿介明,胡新俊.中药对细菌定位转移影响的研究[M]//李兰娟.感染微生态学.北京:人民卫生出版社,2012:66.
    [34]CHANG CJ,LIN CS,LU CC,et al.Ganodermalucidum reduces obesity in mice by modulating the composition of the gut microbiota[J].Nat Commun,2015,6:7489.
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