中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 10
Oct.  2016
Turn off MathJax
Article Contents

Features of immune response during antiviral therapy in patients with chronic hepatitis B

DOI: 10.3969/j.issn.1001-5256.2016.10.007
  • Published Date: 2016-10-20
  • Host immune response is a double-edged sword and participates in liver injury and viral control in patients with HBV infection.Antiviral therapy with nucleos( t) ide analogues and interferon may improve prognosis through regulating host immune response. This article describes the role of host immune response in chronic HBV infection and its features during antiviral therapy and emphasizes the importance of host immune reconstruction in sustained control of HBV infection.

     

  • loading
  • [1]MOMENI M,ZAINODINI N,BIDAKI R,et al.Decreased expression of toll like receptor signaling molecules in chronic HBV infected patients[J].Hum Immunol,2014,75(1):15-19.
    [2]LIU S,PENG N,XIE J,et al.Human hepatitis B virus surface and e antigens inhibit major vault protein signaling in interferon induction pathways[J].J Hepatol,2015,62(5):1015-1023.
    [3]FLETCHER SP,CHIN DJ,JI Y,et al.Transcriptomic analysis of the woodchuck model of chronic hepatitis B[J].Hepatology,2012,56(3):820-830.
    [4]WIELAND S,THIMME R,PURCELL RH,et al.Genomic analysis of the host response to hepatitis B virus infection[J].Proc Natl Acad Sci U S A,2004,101(17):6669-6674.
    [5]DICKSON I.Viral hepatitis:a lack of hepatocyte STING favours HBV infection[J].Nat Rev Gastroenterol Hepatol,2016,13(8):438.
    [6]CHRISTEN V,DUONG F,BERNSMEIER C,et al.Inhibition of alpha interferon signaling by hepatitis B virus[J].J Virol,2007,81(1):159-165.
    [7]BERTOLETTI A,FERRARI C.Innate and adaptive immune responses in chronic hepatitis B virus infections:towards restoration of immune control of viral infection[J].Gut,2012,61(12):1754-1764.
    [8]DECORSIERE A,MUELLER H,van BREUGEL PC,et al.Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor[J].Nature,2016,531(7594):386-389.
    [9]MARTINET J,DUFEU-DUCHESNE T,BRUDER CJ,et al.Altered functions of plasmacytoid dendritic cells and reduced cytolytic activity of natural killer cells in patients with chronic HBV infection[J].Gastroenterology,2012,143(6):1586-1596.
    [10]GHOSH S,NANDI M,PAL S,et al.Natural killer cells contribute to hepatic injury and help in viral persistence during progression of hepatitis B e-antigen-negative chronic hepatitis B virus infection[J].Clin Microbiol Infect,2016.[Epub ahead of print]
    [11]PALLETT LJ,GILL US,QUAGLIA A,et al.Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells[J].Nat Med,2015,21(6):591-600.
    [12]XU X,SHANG Q,CHEN X,et al.Reversal of B-cell hyperactivation and functional impairment is associated with HBs Ag seroconversion in chronic hepatitis B patients[J].Cell Mol Immunol,2015,12(3):309-316.
    [13]DAS A,ELLIS G,PALLANT C,et al.IL-10-producing regulatory B cells in the pathogenesis of chronic hepatitis B virus infection[J].J Immunol,2012,189(8):3925-3935.
    [14]BERTOLETTI A,MAINI MK,FERRARI C.The host-pathogen interaction during HBV infection:immunological controversies[J].Antivir Ther,2010,15(Suppl 3):15-24.
    [15]BENGSCH B,MARTIN B,THIMME R.Restoration of HBV-specific CD8+T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation[J].J Hepatol,2014,61(6):1212-1219.
    [16]BONI C,LAMPERTICO P,TALAMONA L,et al.Natural killer cell phenotype modulation and natural killer/T-cell interplay in nucleos(t)ide analogue-treated hepatitis e antigen-negative patients with chronic hepatitis B[J].Hepatology,2015,62(6):1697-1709.
    [17]KENNEDY PT,SANDALOVA E,JO J,et al.Preserved T-cell function in children and young adults with immune-tolerant chronic hepatitis B[J].Gastroenterology,2012,143(3):637-645.
    [18]SETO WK,CHAN TS,HWANG YY,et al.Hepatitis B reactivation in patients with previous hepatitis B virus exposure undergoing rituximab-containing chemotherapy for lymphoma:a prospective study[J].J Clin Oncol,2014,32(33):3736-3743.
    [19]YAPALI S,TALAAT N,LOK AS.Management of hepatitis B:our practice and how it relates to the guidelines[J].Clin Gastroenterol Hepatol,2014,12(1):16-26.
    [20]HADZIYANNIS SJ,SEVASTIANOS V,RAPTI I,et al.Sustained responses and loss of HBs Ag in HBe Ag-negative patients with chronic hepatitis B who stop long-term treatment with adefovir[J].Gastroenterology,2012,143(3):629-636.
    [21]MELCHJORSEN J,RISOR MW,SOGAARD OS,et al.Tenofovir selectively regulates production of inflammatory cytokines and shifts the IL-12/IL-10 balance in human primary cells[J].J Acquir Immune Defic Syndr,2011,57(4):265-275.
    [22]WU ZG,YAN WM,GUO W,et al.Telbivudine preserves Thelper 1 cytokine production and downregulates programmed death ligand 1 in a mouse model of viral hepatitis[J].J Viral Hepat,2010,17(Suppl 1):24-33.
    [23]TAN AT,HOANG LT,CHIN D,et al.Reduction of HBV replication prolongs the early immunological response to IFNαtherapy[J].J Hepatol,2014,60(1):54-61.
    [24]van der MOLEN RG,SPRENGERS D,BIESTA PJ,et al.Favorable effect of adefovir on the number and functionality of myeloid dendritic cells of patients with chronic HBV[J].Hepatology,2006,44(4):907-914.
    [25]TJWA ET,van OORD GW,HEGMANS JP,et al.Viral load reduction improves activation and function of natural killer cells in patients with chronic hepatitis B[J].J Hepatol,2011,54(2):209-218.
    [26]PEPPA D,MICCO L,JAVAID A,et al.Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infection[J].PLo S Pathog,2010,6(12):e1001227.
    [27]TJWA ET,ZOUTENDIJK R,van OORD GW,et al.Similar frequencies,phenotype and activation status of intrahepatic NK cells in chronic HBV patients after long-term treatment with tenofovir disoproxil fumarate(TDF)[J].Antiviral Res,2016,132:70-75.
    [28]CHEN Y,LI X,YE B,et al.Effect of telbivudine therapy on the cellular immune response in chronic hepatitis B[J].Antiviral Res,2011,91(1):23-31.
    [29]BONI C,LACCABUE D,LAMPERTICO P,et al.Restored function of HBV-specific T cells after long-term effective therapy with nucleos(t)ide analogues[J].Gastroenterology,2012,143(4):963-973.
    [30]EVANS A,RIVA A,COOKSLEY H,et al.Programmed death 1expression during antiviral treatment of chronic hepatitis B:Impact of hepatitis B e-antigen seroconversion[J].Hepatology,2008,48(3):759-769.
    [31]LI Y,MA S,TANG L,et al.Circulating chemokine(C-X-C Motif)receptor 5(+)CD4(+)T cells benefit hepatitis B e antigen seroconversion through IL-21 in patients with chronic hepatitis B virus infection[J].Hepatology,2013,58(4):1277-1286.
    [32]BONI C,PENNA A,BERTOLETTI A,et al.Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B[J].J Hepatol,2003,39(4):595-605.
    [33]BONI C,PENNA A,OGG GS,et al.Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B:new perspectives for immune therapy[J].Hepatology,2001,33(4):963-971.
    [34]PEPPA D,GILL US,REYNOLDS G,et al.Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion[J].J Exp Med,2013,210(1):99-114.
    [35]KONDO Y,UENO Y,KOBAYASHI K,et al.Hepatitis B virus replication could enhance regulatory T cell activity by producing soluble heat shock protein 60 from hepatocytes[J].J Infect Dis,2010,202(2):202-213.
    [36]ALLWEISS L,VOLZ T,LUTGEHETMANN M,et al.Immune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration[J].J Hepatol,2014,60(3):500-507.
    [37]SADLER AJ,WILLIAMS BR.Interferon-inducible antiviral effectors[J].Nat Rev Immunol,2008,8(7):559-568.
    [38]XU C,GUO H,PAN XB,et al.Interferons accelerate decay of replication-competent nucleocapsids of hepatitis B virus[J].J Virol,2010,84(18):9332-9340.
    [39]BELLONI L,ALLWEISS L,GUERRIERI F,et al.IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear ccc DNA minichromosome[J].J Clin Invest,2012,122(2):529-537.
    [40]LUCIFORA J,XIA Y,REISINGER F,et al.Specific and nonhepatotoxic degradation of nuclear hepatitis B virus ccc DNA[J].Science,2014,343(6176):1221-1228.
    [41]MICCO L,PEPPA D,LOGGI E,et al.Differential boosting of innate and adaptive antiviral responses during pegylated-interferonalpha therapy of chronic hepatitis B[J].J Hepatol,2013,58(2):225-233.
    [42]REHERMANN B,LAU D,HOOFNAGLE JH,et al.Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection[J].J Clin Invest,1996,97(7):1655-1665.
    [43]MARCELLIN P,AHN SH,MA X,et al.Combination of tenofovir disoproxil fumarate and peginterferon alpha-2a increases loss of hepatitis B surface antigen in patients with chronic hepatitis B[J].Gastroenterology,2016,150(1):134-144.
    [44]XIE Q,ZHOU H,BAI X,et al.A randomized,open-label clinical study of combined pegylated interferon alfa-2a(40KD)and entecavir treatment for hepatitis B“e”antigen-positive chronic hepatitis B[J].Clin Infect Dis,2014,59(12):1714-1723.
    [45]CAREY I,D'ANTIGA L,BANSAL S,et al.Immune and viral profile from tolerance to hepatitis B surface antigen clearance:a longitudinal study of vertically hepatitis B virus-infected children on combined therapy[J].J Virol,2011,85(5):2416-2428.
    [46]de NIET A,STELMA F,JANSEN L,et al.Restoration of T cell function in chronic hepatitis B patients upon treatment with interferon based combination therapy[J].J Hepatol,2016,64(3):539-546.
    [47]BRUDER CJ,DUFEU-DUCHESNE T,LEROY V,et al.Pegylated interferon alpha-2a triggers NK-cell functionality and specific T-cell responses in patients with chronic HBV infection without HBs Ag seroconversion[J].PLo S One,2016,11(6):e158297.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2369) PDF downloads(560) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return