中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 10
Oct.  2016
Turn off MathJax
Article Contents

Roles of regulatory T cells and T-helper cells in hepatitis B virus-related liver diseases

DOI: 10.3969/j.issn.1001-5256.2016.10.040
Research funding:

 

  • Published Date: 2016-10-20
  • In recent years,the role of immune cells in hepatitis B virus( HBV)-related liver diseases has attracted more and more attention. This article reviews the roles of regulatory T cells( Treg) and T-helper cell type 17( Th17) in the development,progression,and prognosis of HBV-related liver diseases,especially HBV-related liver fibrosis and liver failure,as well as hepatocellular carcinoma. It is pointed out that the dynamic changes of Treg and Th17 cells in different stages of HBV infection and their roles in hepatocellular carcinoma need further investigation,and future studies on the regulatory effects of various signaling pathways on Treg or Th17 cells are needed to provide a more precise direction for the treatment of HBV-related diseases.

     

  • loading
  • [1]IELUZZI D,COVOLO L,DONATO F,et al.Progression to cirrhosis,hepatocellular carcinoma and liver-related mortality in chronic hepatitis B patients in Italy[J].Dig Liver Dis,2014,46(5):427-432.
    [2]BALMASOVA IP,YUSHCHUK ND,MYNBAEV OA,et al.Immunopathogenesis of chronic hepatitis B[J].World J Gastroenterol,2014,20(39):14156-14171.
    [3]UTSUNOMIYA T,SSHIMADA M,KUDO M,et al.A comparison of the surgical outcomes among patients with HBV-positive,HCV-positive,and non-B non-C hepatocellular carcinoma:a nationwide study of 11,950 patients[J].Ann Surg,2015,261(3):513-520.
    [4]Mc MAHON BJ.The natural history of chronic hepatitis B virus infection[J].Hepatology,2009,49(Suppl 5):s45-s55.
    [5]HUANG Y,ZHU ZY,DU Z.Research progress on Th17/Treg involved in hepatic diseases[J].Int J Lab Med,2011,32(16):1856-1858.(in Chinese)黄勇,朱争艳,杜智.Th17/Treg在肝脏疾病中的作用研究进展[J].国际检验医学杂志,2011,32(16):1856-1858.
    [6]HE JN,ZHAO SS.Research advances in association between regulatory T cells and hepatitis B virus infection[J].J Clin Hepatol,2016,32(2):361-365.(in Chinese)何俊楠,赵守松.调节性T淋巴细胞与HBV感染慢性化的关系[J].临床肝胆病杂志,2016,32(2):361-365.
    [7]ALATRAKCHI N,KOZIEL M.Regulatory T cells and viral liver disease[J].J Viral Hepat,2009,16(4):223-229.
    [8]CMARA NO,SEBILLE F,LECHLER RI.Human CD4+CD25+regulatory cells have marked and sustained effects on CD8+T cell activation[J].Eur J Immunol,2003,33(12):3473-3483.
    [9]WANG W,SHAO S,JIAO Z,et al.The Th17/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritis[J].Rheumatol Int,2012,32(4):887-893.
    [10]YE Y,XIE X,YU J,et al.Involvement of Th17 and Th1 effector responses in patients with hepatitis B[J].J Clin Immunol,2010,30(4):546-555.
    [11]YAN J,LIU XL,XIAO G,et al.Prevalence and clinical relevance of T-helper cells,Th17 and Th1,in hepatitis B virus-related hepatocellular carcinoma[J].PLo S One,2014,9(5):e96080.
    [12]ANNUNZIATO F,COSMI L,SANTARLASCI V,et al.Phenotypic and functional features of human Th17 cells[J].J Exp Med,2007,204(8):1849-1861.
    [13]OUYANG W,KOLLS JK,ZHENG Y.The biological functions of T helper 17 cell effector cytokines in inflammation[J].Immunity,2008,28(4):454-467.
    [14]HAMMERICH L,HEYMANN F,TACKE F.Role of IL-17 and Th17 cells in liver diseases[J].Clin Dev Immunol,2011,2011:345803.
    [15]IVANOV II,Mc KENZIE BS,ZHOU L,et al.The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+T helper cells[J].Cell,2006,126(6):1121-1133.
    [16]LI J,QIU SJ,SHE WM,et al.Significance of the balance between regulatory T(Treg)and T helper 17(Th17)cells during hepatitis B virus related liver fibrosis[J].PLo S One,2012,7(6):e39307.
    [17]STOOP JN,van der MOLEN RG,BAAN CC,et al.Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection[J].Hepatology,2005,41(4):771-778.
    [18]PENG G,LI S,WU W,et al.Circulating CD4+CD25+regulatory T cells correlate with chronic hepatitis B infection[J].Immunology,2008,123(1):57-65.
    [19]XU D,FU J,JIN L,et al.Circulating and liver resident CD4+CD25+regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B[J].J Immunol,2006,177(1):739-747.
    [20]WANG Q,ZHENG Y,HUANG Z,et al.Activated IL-23/IL-17 pathway closely correlates with increased Foxp3 expression in livers of chronic hepatitis B patients[J].BMC Immunol,2011,12(1):25.
    [21]LI CD,CHEN XL,TIAN PF,et al.Correlation analysis of percentages of T lymphocyte subsets and CD4+CD25+regulatory T cells and HBV DNA level in peripheral blood of chronic hepatitis B patients[J].J Clin Hepatol,2015,31(4):541-545.(in Chinese)李彩东,陈锡莲,田鹏飞,等.慢性乙型肝炎患者外周血中T淋巴细胞亚群和CD4+CD25+调节性T淋巴细胞的表达水平与HBV DNA定量的相关分析[J].临床肝胆病杂志,2015,31(4):541-545.
    [22]WANG FS.Clinical immune characterization of hepatitis B virus infection and implications for immune intervention:progress and challenges[J].Hepatol Res,2007,37(Suppl 3):s339-s346.
    [23]FRANZESE O,KENNEDY PT,GEHRING AJ,et al.Modulation of the CD8+-T-cell response by CD4+CD25+regulatory T cells in patients with hepatitis B virus infection[J].J Virol,2005,79(6):3322-3328.
    [24]STROSS L,GNTHER J,GASTEIGER G,et al.Foxp3+regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice[J].Hepatology,2012,56(3):873-883.
    [25]CHEN Y,FANG J,CHEN X,et al.Effects of the Treg/Th17 cell balance and their associated cytokines in patients with hepatitis B infection[J].Exp Ther Med,2015,9(2):573-578.
    [26]WEI HX,CHUANG YH,LI B,et al.CD4+CD25+Foxp3+regulatory T cells protect against T cell-mediated fulminant hepatitis in a TGFβ-dependent manner in mice[J].J Immunol,2008,181(10):7221-7229.
    [27]ERHARDT A,BIBURGER M,PAPADOPOULOS T,et al.IL-10,regulatory T cells,and Kupffer cells mediate tolerance in concanavalin A-induced liver injury in mice[J].Hepatology,2007,45(2):475-485.
    [28]WANG F,JING X,LI G,et al.Foxp3+regulatory T cells are associated with the natural history of chronic hepatitis B and poor prognosis of hepatocellular carcinoma[J].Liver Int,2012,32(4):644-655.
    [29]ZHANG H,MEI M,FEI R,et al.Regulatory T cells in chronic hepatitis B patients affect the immunopathogenesis of hepatocellular carcinoma by suppressing the anti-tumour immune responses[J].J Viral Hepat,2010,17(Suppl 1):34-43.
    [30]HUANG Y,WANG F,WANG Y,et al.Intrahepatic interleukin-17+T cells and Foxp3+regulatory T cells cooperate to promote development and affect the prognosis of hepatocellular carcinoma[J].J Gastroenterol Hepatol,2014,29(4):851-859.
    [31]HUANG Y,WANG FM,WANG T,et al.Tumor-infiltrating Foxp3+Tregs and CD8+T cells affect the prognosis of hepatocellular carcinoma patients[J].Digestion,2012,86(4):329-337.
    [32]SUN H,ZHANG J,ZHANG H,et al.Increased Th17 cells contribute to disease progression in patients with HBV‐associated liver cirrhosis[J].J Viral Hepat,2012,19(6):396-403.
    [33]HUANG JF,XU T,PAN XN,et al.Measurement of peripheral blood Treg,Tr1,and Th17 cells in patients with chronic hepatitis B and its clinical significance[J].J Clin Hepatol,2015,31(4):551-555.(in Chinese)黄进发,徐涛,潘兴南,等.慢性乙型肝炎患者外周血中调节性T淋巴细胞,Ⅰ型调节性T淋巴细胞和辅助性T淋巴细胞17的表达特点及临床意义[J].临床肝胆病杂志,2015,31(4):551-555.
    [34]WANG L,CHEN S,XU K.IL-17 expression is correlated with hepatitis B-related liver diseases and fibrosis[J].Int J Mol Med,2011,27(3):385-392.
    [35]TAN Z,QIAN X,JIANG R,et al.IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation[J].J Immunol,2013,191(4):1835-1844.
    [36]ZHAO J,ZHANG Z,LUAN Y,et al.Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment[J].Hepatology,2014,59(4):1331-1342.
    [37]ZHANG F,YAO S,YUAN J,et al.Elevated IL-6 receptor expression on CD4+T cells contributes to the increased Th17 responses in patients with chronic hepatitis B[J].Virol J,2011,8:270.
    [38]NUMASAKI M,FUKUSHI JI,ONO M,et al.Interleukin-17 promotes angiogenesis and tumor growth[J].Blood,2003,101(7):2620-2627.
    [39]GRETEN TF,ZHAO F,GAMREKELASHVILI J,et al.Human Th17 cells in patients with cancer:friends or foe?[J].Oncoimmunology,2012,1(8):1438-1439.
    [40]ZHANG X,ZHENG X,HE F,et al.Expression of interleukin-17A in primary liver cancer and its clinical significance[J].Chin J Hepatobiliary Surg,2013,19(2):143-146.(in Chinese)张玄,郑翔,何凡,等.原发性肝癌中白细胞介素-17A的表达及其临床意义[J].中华肝胆外科杂志,2013,19(2):143-146.
    [41]ZHAO F,HOECHST B,GAMREKELASHVILI J,et al.Human CCR4+CCR6+Th17 cells suppress autologous CD8+T cell responses[J].J Immunol,2012,188(12):6055-6062.
    [42]LIAO Y,WANG B,HUANG ZL,et al.Increased circulating Th17cells after transarterial chemoembolization correlate with improved survival in stage III hepatocellular carcinoma:a prospective study[J].PLo S One,2013,8(4):e60444.
    [43]ZHANG GL,XIE DY,LIN BL,et al.Imbalance of interleukin-17-producing CD4 T cells/regulatory T cells axis occurs in remission stage of patients with hepatitis B virus-related acute-onchronic liver failure[J].J Gastroenterol Hepatol,2013,28(3):513-521.
    [44]LIANG XS,LI CZ,ZHOU Y,et al.Changes in circulating Foxp3+regulatory T cells and interleukin-17-producing T helper cells during HBV-related acute-on-chronic liver failure[J].World J Gastroenterol,2014,20(26):8558.
    [45]DONG X,GONG Y,ZENG H,et al.Imbalance between circulating CD4+regulatory T and conventional T lymphocytes in patients with HBV-related acute-on-chronic liver failure[J].Liver Int,2013,33(10):1517-1526.
    [46]YANG B,WANG Y,ZHAO C,et al.Increased Th17 cells and interleukin-17 contribute to immune activation and disease aggravation in patients with chronic hepatitis B virus infection[J].Immunol Lett,2013,149(1-2):41-49.
    [47]NIU Y,LIU H,YIN D,et al.The balance between intrahepatic IL-17+T cells and Foxp3+regulatory T cells plays an important role in HBV-related end-stage liver disease[J].BMC Immunol,2011,12:47.
    [48]KIM HY,JHUN JY,CHO ML,et al.Interleukin-6 upregulates Th17 response via m TOR/STAT3 pathway in acute-on-chronic hepatitis B liver failure[J].J Gastroenterol,2014,49(8):1264-1273.
    [49]YU X,GUO R,MING D,et al.Ratios of regulatory T cells/Thelper 17 cells and transforming growth factor-β1/interleukin-17to be associated with the development of hepatitis B virus-associated liver cirrhosis[J].J Gastroenterol Hepatol,2014,29(5):1065-1072.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (373) PDF downloads(102) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return