[1]BRUIX J,REIG M,SHERMAN M.Evidence-based diagnosis,staging,and treatment of patients with hepatocellular carcinoma[J].Gastroenterology,2016,150(4):835-853.
|
[2]CHEN W,ZHENG R,BAADE PD,et al.Cancer statistics in China,2015[J].CA cancer J Clin,2016,66(2):115-132.
|
[3]CHOW AK,YAU TC,NG L,et al.A preclinical study on the combination therapy of everolimus and transarterial chemoembolization in hepatocellular carcinoma[J].Am J Cancer Res,2015,5(8):2376-2386.
|
[4]XUE TM,TAO LD,ZHANG M,et al.Clinicopathological significance of microRNA-20b expression in hepatocellular carcinoma and regulation of HIF-1αand VEGF effect on cell biological behaviour[J].Dis Markers,2015,2015:325176.
|
[5]LEWANDOWSKI RJ,ANDREOLI JM,HICKEY R,et al.Angiogenic response following radioembolization:results from a randomized pilot study of yttrium-90 with or without sorafenib[J].J Vasc Interv Radiol,2016,27(9):1329-1336.
|
[6]XI S,PENG Y,MINUK GY,et al.The combination effects of Shen-Ling-Bai-Zhu on promoting apoptosis of transplanted H22hepatocellular carcinoma in mice receiving chemotherapy[J].JEthnopharmacol,2016,190(1):1-12.
|
[7]BUPATHI M,KASEB A,JANKU F.Angiopoietin 2 as a therapeutic target in hepatocellular carcinoma treatment:current perspectives[J].Onco Targets Ther,2014,7:1927-1932.
|
[8]RIVIRE L,DUCROUX A,BUENDIA MA.The oncogenic role of hepatitis B virus[J].Recent Results Cancer Res,2014,193(1):59-74.
|
[9]HE YF,WANG CQ,YU Y,et al.Tie2-expressing monocytes are associated with identification and prognoses of hepatitis B virus related hepatocellular carcinoma after resection[J].PLoS One,2015,10(11):e0143657.
|
[10]LU Y,SUI J,LIU Y,et al.Association between hypoxia-inducible factor-1αgene polymorphisms and risk of chronic hepatitis Band hepatitis B virus-related liver cirrhosis in a Chinese population:a retrospective case-control study[J].Gene,2015,564(1):96-100.
|
[11]ZHU M,GUO J,LI W,et al.Hepatitis B virus X protein induces expression of alpha-fetoprotein and activates PI3K/mT OR signaling pathway in liver cells[J].Oncotarget,2015,6(14):12196-12208.
|
[12]VASSILAKI N,KALLIAMPAKOU KI,KOTTA-LOIZOU I,et al.Low oxygen tension enhances hepatitis C virus replication[J].JVirol,2013,87(5):2935-2948.
|
[13]WILSON GK,BRIMACOMBE CL,ROWE IA,et al.A dual role for hypoxia inducible factor-1αin the hepatitis C virus lifecycle and hepatoma migration[J].J Hepatol,2012,56(4):803-809.
|
[14]LEE SH,CHUNG YH,KIM JA,et al.Single nucleotide polymorphisms associated with metastatic tumour antigen 1 overexpression in patients with hepatocellular carcinoma[J].Liver Int,2012,32(3):457-466.
|
[15]NASIMUZZAMAN M,WARIS G,MIKOLN D,et al.Hepatitis Cvirus stabilizes hypoxia-inducible factor 1alpha and stimulates the synthesis of vascular endothelial growth factor[J].J Virol,2007,81(19):10249-10257.
|
[16]YAO DF,JIANG H,YAO M,et al.Quantitative analysis of hepatic hypoxia-inducible factor-1alpha and its abnormal gene expression during the formation of hepatocellular carcinoma[J].Hepatobiliary Pancreat Dis Int,2009,8(4):407-413.
|
[17]LI Y,GUO B,XIE Q,et al.STIM1 mediates hypoxia-driven hepatocarcinogenesis via interaction with HIF-1[J].Cell Rep,2015,12(3):388-395.
|
[18]YAO DF,QIU LW,WU W,et al.Dynamic alterations of VEGFand intervention of its expression on effect of hepatocyte malignant transformation[J].Natl Med J China,2010,90(42):3014-3018.(in Chinese)姚登福,邱历伟,吴玮,等.血管内皮生长因子动态表达及干预对肝细胞癌变的影响[J].中华医学杂志,2010,90(42):3014-3018.
|
[19]LAI FB,LIU WT,JING YY,et al.Lipopolysaccharide supports maintaining the stemness of CD133+hepatoma cells through activation of the NF-κB/HIF-1αpathway[J].Cancer Lett,2016,378(2):131-141.
|
[20]YE LY,CHEN W,BAI XL,et al.Hypoxia-induced epithelialto-mesenchymal transition in hepatocellular carcinoma induces an immunosuppressive tumor microenvironment to promote metastasis[J].Cancer Res,2016,76(4):818-830.
|
[21]HU F,DENG X,YANG X,et al.Hypoxia upregulates Rab11-family interacting protein 4 through HIF-1αto promote the metastasis of hepatocellular carcinoma[J].Oncogene,2015,34(49):6007-6017.
|
[22]ZHUANG PY,WANG JD,TANG ZH,et al.Higher proliferation of peritumoral endothelial cells to IL-6/sI L-6R than tumoral endothelial cells in hepatocellular carcinoma[J].BMC Cancer,2015,15:830.
|
[23]LI S,YAO D,WANG L,et al.Expression characteristics of hypoxia-inducible factor-1αand its clinical values in diagnosis and prognosis of hepatocellular carcinoma[J].Hepat Mon,2011,11(10):821-828.
|
[24]MATSUBARA T,KANTO T,KURODA S,et al.TIE2-expressing monocytes as a diagnostic marker for hepatocellular carcinoma correlates with angiogenesis[J].Hepatology,2013,57(4):1416-1425.
|
[25]SHARMA BK,SRINIVASAN R,KAPIL S,et al.Serum levels of angiogenic and anti-angiogenic factors:their prognostic relevance in locally advanced hepatocellular carcinoma[J].Mol Cell Biochem,2013,383(1-2):103-112.
|
[26]VILLA E,CRITELLI R,LEI B,et al.Neoangiogenesis-related genes are hallmarks of fast-growing hepatocellular carcinomas and worst survival.Results from a prospective study[J].Gut,2016,65(5):861-869.
|
[27]CAMPILLO A,SOLANAS E,MORANDEIRA MJ,et al.Angiogenesis and proliferation markers in adjacent cirrhotic tissue could predict hepatocellular carcinoma outcome after liver transplantation[J].Eur J Gastroenterol Hepatol,2014,26(8):871-879.
|
[28]LIU L,LI SQ,MI XG,et al.Relationship of clinical outcomes and expression of microRNA-199a/b-3p in HCC[J].Chin J Immunol,2015,31(6):806-808.(in Chinese)刘磊,李首庆,米旭光,等.microRNA-199a/b-3p表达与肝细胞癌临床预后的相关性[J].中国免疫学杂志,2015,31(6):806-808.
|
[29]HUNG CL,YEN CS,TSAI HW,et al.Upregulation of MicroRNA-19b predicts good prognosis in patients with hepatocellular carcinoma presenting with vascular invasion or multifocal disease[J].BMC Cancer,2015,15:665.
|
[30]CHAI ZT,KONG J,ZHU XD,et al.MicroRNA-26a inhibits angiogenesis by down-regulating VEGFA through the PIK3C2α/Akt/HIF-1αpathway in hepato-cellular carcinoma[J].PLoS One,2013,8(10):e77957.
|
[31]WANG YH,DONG YY,WANG WM,et al.Vascular endothelial cells facilitated HCC invasion and metastasis through the Akt and NF-κB pathways induced by paracrine cytokines[J].J Exp Clin Cancer Res,2013,32(1):51.
|
[32]WON C,KIM BH,YI EH,et al.Signal transducer and activator of transcription 3-mediated CD133 up-regulation contributes to promotion of hepatocellular carcinoma[J].Hepatology,2015,62(4):1160-1173.
|
[33]LIN D,WU J.Hypoxia inducible factor in hepatocellular carcinoma:a therapeutic target[J].World J Gastroenterol,2015,21(42):12171-12178.
|
[34]LI H,CHEN J,ZEN W,et al.Effect of hypoxia inducible factor-1 antisense oligonucleotide on liver cancer[J].Int J Clin Exp Med,2015,8(8):12650-12655.
|
[35]LAI KG,LIN YH,HO CT,et al.Paclitaxel pretreatment overcomes hypoxia inducible factor-1α-induced radioresistance acquisition of human hepatoma and lung adenocarcinoma cells[J].Life Sci,2015,136(1):7-12.
|
[36]CHOI SH,PARK JY,KANG W,et al.Knockdown of HIF-1αand IL-8 induced apoptosis of hepatocellular carcinoma triggers apoptosis of vascular endothelial cells[J].Apoptosis,2016,21(1):85-95.
|
[37]WANG L,YAO M,YAN MJ,et al.Silencing hypoxia-inducible factor-1αgene transcription on effects of human hep G2 cell proliferation and angiogenesis factors[J].J Pure App Microbiol,2013,7:461-467.
|
[38]HAN KQ,HE XQ,MA MY,et al.Targeted silencing of CXCL1 by siRNA inhibits tumor growth and apoptosis in hepatocellular carcinoma[J].Int J Oncol,2015,47(6):2131-2140.
|
[39]LU S,GAO Y,HUANG X,et al.GYY4137,a hydrogen sulfide(H2S)donor,shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway[J].Int J Oncol,2014,44(4):1259-1267.
|
[40]LIU X,CHEN S,TU J,et al.HSP90 inhibits apoptosis and promotes growth by regulating HIF-1αabundance in hepatocellular carcinoma[J].Int J Mol Med,2016,37(3):825-835.
|
[41]ZHAO HZ,QIQI G.Clinical analysis of 207 cases with promary hepatcellular carcinoma[J/CD].Chin J Liver Dis:Electronic Edition,2015,7(3):89-97.(in Chinese)赵海珍,其其格,207例原发性肝细胞癌患者临床分析[J/CD].中国肝脏病杂志:电子版,2015,7(3):89-97.
|
[42]MALVICINI M,AQUINO JB,MAZZOLINI G.Combined therapy for gastrointestinal carcinomas:exploiting synergies between gene therapy and classical chemo-radiotherapy[J].Curr Gene Ther,2015,15(2):151-160.
|
[43]MA F,HU L,YU M,et al.Emodin decreases hepatic hypoxiainducible factor-1αby inhibiting its biosynthesis[J].Am J Chin Med,2016,44(5):997-1008.
|