[1]SØRENSEN KK, SIMON-SANTAMARIA J, McC USKEY RS, et al.Liver sinusoidal endothelial cells[J].Compr Physiol, 2015, 5 (4) :1751-1774.
|
[2]KAWAI T, AKIRA S.The role of pattern-recognition receptors in innate immunity:update on Toll-like receptors[J].Nat Immunol, 2010, 11 (5) :373-384.
|
[3]LIMMER A, OHL J, KURTS C, et al.Efficient presentation of exogenous antigen by liver endothelial cells to CD8+T cells results in antigen-specific T-cell tolerance[J].Nat Med, 2000, 6 (12) :1348-1354.
|
[4]IWAKIRI Y, GROSZMANN RJ.Vascular endothelial dysfunction in cirrhosis[J].J Hepatol, 2007, 46 (5) :927-934.
|
[5]ZHOU W, ZHANG Q, QIAO L.Pathogenesis of liver cirrhosis[J].World J Gastroenterol, 2014, 20 (23) :7312.
|
[6]XU B, BROOME U, UZUNEL M, et al.Capillarization of hepatic sinusoid by liver endothelial cell-reactive autoantibodies in patients with cirrhosis and chronic hepatitis[J].Am J Pathol, 2003, 163 (4) :1275-1289.
|
[7]CONNOLLY MK, BEDROSIAN AS, MALHOTRA A, et al.In hepatic fibrosis, liver sinusoidal endothelial cells acquire enhanced immunogenicity[J].J Immunol, 2010, 185 (4) :2200-2208.
|
[8]HUANG YH, GUO QL, CHEN ZX, et al.Changes of liver sinusoidal endothelial cells and basement membrane in early stage of liver fibrosis induced by carbon tetrachloride in rats[J].Chin J Pathophysiol, 2014, 30 (8) :1501-1505. (in Chinese) 黄月红, 郭杞兰, 陈治新, 等.四氯化碳诱导肝纤维化早期大鼠肝窦内皮细胞及基底膜形态改变的动态研究[J].中国病理生理杂志, 2014, 30 (8) :1501-1505.
|
[9]WANG XB, LIU P, TANG ZP, et al.Role of injury and phenotype shift of liver sinusoidal endothelial cells in the development of portal hypertension of cirrhosis in rats[J].Chin J Pathophysiol, 2005, 21 (9) :1811-1816. (in Chinese) 王宪波, 刘平, 唐志鹏, 等.肝窦内皮细胞损伤和表型改变在大鼠肝硬化门脉高压发生中的作用[J].中国病理生理杂志, 2005, 21 (9) :1811-1816.
|
[10]DOI T, YAMADA G, MIZUNO M, et al.Immunohistochemical study of the distribution of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 in chronic type B hepatitis[J].J Gastroenterol, 1994, 29 (2) :164-171.
|
[11]DeL EVE LD, WANG X, HU L, et al.Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation[J].Am J Physiol Gastrointest Liver Physiol, 2004, 287 (4) :g757-g763.
|
[12]DeL EVE LD.Liver sinusoidal endothelial cells in hepatic fibrosis[J].Hepatology, 2015, 61 (5) :1740-1746.
|
[13]LU X, LIU P, LIU CH, et al.Role of hepatic sinusoidal endothelium injury in hepatic fibrogenesis induced by dimethylnitrosamine in rats[J].Chin J Hepatol, 2002, 10 (6) :42-45. (in Chinese) 陆雄, 刘平, 刘成海, 等.肝窦内皮细胞损伤在大鼠肝纤维化形成中的作用[J].中华肝脏病杂志, 2002, 10 (6) :42-45.
|
[14]BHUNCHET E, FUJIEDA K.Capillarization and venularization of hepatic sinusoids in porcine serum-induced rat liver fibrosis:a mechanism to maintain liver blood flow[J].Hepatology, 1993, 18 (6) :1450-1458.
|
[15]WANG BY, FU BY, ZHANG J, et al.The influence of alcohol on the liver sinusoids endothelial cell fenestrae of rats[J].Chin J Hepatol, 2004, 12 (8) :43-45. (in Chinese) 王炳元, 傅宝玉, 张健, 等.乙醇对大鼠肝窦内皮细胞窗孔的影响[J].中华肝脏病杂志, 2004, 12 (8) :43-45.
|
[16]ZHAO YQ, WANF BY, LIU Q.Successive observation of liver sinusoids endothelial cell fenestrae during formation of non-alcoholic fatty liver fibrosis in rabbit[J].China J Modern Med, 2008, 18 (6) :699-701. (in Chinese) 赵迎庆, 王炳元, 刘强.实验性家兔非酒精性肝纤维化形成过程中肝窦内皮细胞的变化[J].中国现代医学杂志, 2008, 18 (6) :699-701.
|
[17]CHELUVAPPA R, DENNING GM, LAU GW, et al.Pathogenesis of the hyperlipidemia of Gram-negative bacterial sepsis may involve pathomorphological changes in liver sinusoidal endothelial cells[J].Int J Infect Dis, 2010, 14 (10) :e857-e867.
|
[18]HWANG G.Current research trends in the exploration of therapeutic targets for liver disease:foreword[J].Biol Pharm Bull, 2015, 38 (7) :960.
|
[19]ZHANG Z, ZHANG F, LU Y, et al.Update on implications and mechanisms of angiogenesis in liver fibrosis[J].Hepatol Res, 2015, 45 (2) :162-178.
|
[20]WEISKIRCHEN R, TACKE F.Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology[J].Hepatobiliary Surg Nutr, 2014, 3 (6) :344-363.
|
[21]ROCKEY DC, BISSELL DM.Noninvasive measures of liver fibrosis[J].Hepatology, 2006, 43 (2 Suppl 1) :s113-s120.
|
[22]DeL EVE LD, WANG X, GUO Y.Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence[J].Hepatology, 2008, 48 (3) :920-930.
|
[23]ALONSO CR, GEORGE J, PESCE CG, et al.Fibronectin transcription in liver cells:promoter occupation and function in sinusoidal endothelial cells and hepatocytes[J].Biochem Biophys Res Commun, 2002, 295 (5) :1077-1084.
|
[24]FERNANDEZ M.Molecular pathophysiology of portal hypertension[J].Hepatology, 2015, 61 (4) :1406-1415.
|
[25]MARVIE P, LISBONNE M, L'HELGOUALC'H A, et al.Interleukin-33 overexpression is associated with liver fibrosis in mice and humans[J].J Cell Mol Med, 2010, 14 (6B) :1726-1739.
|
[26]ELPEK GO.Cellular and molecular mechanisms in the pathogenesis of liver fibrosis:an update[J].World J Gastroenterol, 2014, 20 (23) :7260.
|
[27]LI JM, YAN J, LYU WL, et al.Mechanism of liver sinusoidal endothelial cells involved in liver fibrosis[J].J Dalian Med Univ, 2013, 35 (1) :81-83. (in Chinese) 李娟梅, 闫洁, 吕文良, 等.肝窦内皮细胞参与肝纤维化的机制[J].大连医科大学学报, 2013, 35 (1) :81-83.
|
[28]MARRONE G, SHAH VH, GRACIA-SANCHO J.Sinusoidal communication in liver fibrosis and regeneration[J].J Hepatol, 2016, 65 (3) :608-617.
|
[29]BORKHAM-KAMPHORST E, van ROEYEN CR, OSTENDORF T, et al.Pro-fibrogenic potential of PDGF-D in liver fibrosis[J].J Hepatol, 2007, 46 (6) :1064-1074.
|
[30]LIU X, HU H, YIN JQ.Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosis[J].Liver Int, 2006, 26 (1) :8-22.
|
[31]CUI Q, WANG Z, JIANG D, et al.HGF inhibits TGF-beta1-induced myofibroblast differentiation and ECM deposition via MMP-2 in Achilles tendon in rat[J].Eur J Appl Physiol, 2011, 111 (7) :1457-1463.
|
[32]ZHANG SS, LYU WL, ZHANG X, et al.Research advances of sinusoidal endothelial cell and hepatic fibrosis[J].Chin Arch Tradit Chin Med, 2012, 30 (7) :1508-1510. (in Chinese) 张莎莎, 吕文良, 张旭, 等.肝窦内皮细胞与肝纤维化形成的研究概况[J].中华中医药学刊, 2012, 30 (7) :1508-1510.
|
[33]POISSON J, LEMOINNE S, BOULANGER C, et al.Liver sinusoidal endothelial cells:physiology and role in liver diseases[J].JHepatol, 2016, 66 (1) :212-227.
|
[34]SEKI E, de MINICIS S, OSTERREICHER CH, et al.TLR4 enhances TGF-beta signaling and hepatic fibrosis[J].Nat Med, 2007, 13 (11) :1324-1332.
|
[35]YANG L, SEKI E.Toll-like receptors in liver fibrosis:cellular crosstalk and mechanisms[J].Front Physiol, 2012, 3 (138) :138.
|
[36]GRACIA-SANCHO J, LAVINA B, RODRIGUEZ-VILARRU-PLA A, et al.Increased oxidative stress in cirrhotic rat livers:a potential mechanism contributing to reduced nitric oxide bioavailability[J].Hepatology, 2008, 47 (4) :1248-1256.
|
[37]BAUER M, BAUER I, SONIN NV, et al.Functional significance of endothelin B receptors in mediating sinusoidal and extrasinusoidal effects of endothelins in the intact rat liver[J].Hepatology, 2000, 31 (4) :937-947.
|
[38]IWAKIRI Y.Endothelial dysfunction in the regulation of cirrhosis and portal hypertension[J].Liver Int, 2012, 32 (2) :199-213.
|
[39]TANG ZP, LIU P, WANG XB.Effect of Cordyceps mycelia extract on hepatic sinusoidal endothelial cells permeability in dimethylnitrosamine-induced liver fibrosis in rats[J].Chin J New Drugs Clin Remed.2006, 25 (9) :713-717. (in Chinese) 唐志鹏, 刘平, 王宪波.虫草菌丝提取物对DMN诱导肝纤维化大鼠肝窦内皮细胞通透性影响[J].中国新药与临床杂志.2006 (09) :713-717.
|
[40]MU XH, ZHANG SM.Effect of total glycosides in Radix Paeoniae Alba on liver sinusoidal endothelial cells and expression of serum tumor necrosis factor-αin rats with fibrosis[J].Guangming Tradit Chin Med, 2009, 24 (4) :745-746. (in Chinese) 穆晓红, 张双明.白芍总甙对大鼠肝纤维化形成中肝窦内皮细胞的作用及血清TNF-α的表达研究[J].光明中医, 2009, 24 (4) :745-746.
|
[41]YU YQ.Effect of Fuzhenghuayu decoction on hepatic stellate cell and liver sinusoidal endothelial cell[D].Central South University, 2012. (in Chinese) 余燕青.扶正化瘀方对肝星形细胞和肝窦内皮细胞影响的实验研究[D].中南大学, 2012.
|
[42]MORRIS JC, TAN AR, OLENCKI TE, et al.Phase I study of GC1008 (fresolimumab) :a human anti-transforming growth factor-beta (TGFbeta) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma[J].PLoS One, 2014, 9 (3) :e90353.
|
[43]RICE LM, PADILLA CM, MCLAUGHLIN SR, et al.Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients[J].J Clin Invest, 2015, 125 (7) :2795-2807.
|
[44]di SARIO A, BENDIA E, SVEGLIATI BG, et al.Effect of pirfenidone on rat hepatic stellate cell proliferation and collagen production[J].J Hepatol, 2002, 37 (5) :584-591.
|
[45]YOU Q, KONG LJ, LI FD, et al.Human recombinant endostatin Endostar attenuates hepatic sinusoidal endothelial cell capillarization in CCl4 induced fibrosis in mice[J].Mol Med Rep, 2015, 12 (4) :5594-5600.
|
[46]XIE G, WANG X, WANG L, et al.Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats[J].Gastroenterology, 2012, 142 (4) :918-927.
|
[47]HUANG Y, FENG H, KAN T, et al.Bevacizumab attenuates hepatic fibrosis in rats by inhibiting activation of hepatic stellate cells[J].PLoS One, 2013, 8 (8) :e73492.
|
[48]SCHUPPAN D, KIM YO.Evolving therapies for liver fibrosis[J].JClin Invest, 2013, 123 (5) :1887-1901.
|
[49]YAN Z, QU K, ZHANG J, et al.CD147 promotes liver fibrosis progression via VEGF-A/VEGFR2 signalling-mediated crosstalk between hepatocytes and sinusoidal endothelial cells[J].Clin Sci (Lond) , 2015, 129 (8) :699-710.
|
[50]BARRY-HAMILTON V, SPANGLER R, MARSHALL D, et al.Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment[J].Nat Med, 2010, 16 (9) :1009-1017.
|
[51]VAIRAPPAN B.Endothelial dysfunction in cirrhosis:role of inflammation and oxidative stress[J].World J Hepatol, 2015, 7 (3) :443.
|