Association between γ-glutamyl transpeptidase-to-platelet ratio and hepatic fibrosis in patients with chronic hepatitis B

Dong JingJing; Guo HongHua

doi:10.3969/j.issn.1001-5256.2017.03.034

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Mar. 2017

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Article Navigation > Journal of Clinical Hepatology > 2017 > 33(3): 548-552

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Association between γ-glutamyl transpeptidase-to-platelet ratio and hepatic fibrosis in patients with chronic hepatitis B

DOI: 10.3969/j.issn.1001-5256.2017.03.034

Department of Gastroenterology, China-Japan Union Hospital of Jilin University

Research funding:

Received Date: 2016-09-14
Published Date: 2017-03-20

Abstract

Abstract

Early and accurate diagnosis of hepatic fibrosis and application of antiviral therapy are the key to improving the prognosis of patients with chronic hepatitis B (CHB) .Liver biopsy and transient elastography cannot be widely used for the diagnosis of hepatic fibrosis in clinical practice, and therefore, the serological diagnostic model has become a hot research topic in recent years.This article introduces a new serological diagnostic model, γ-glutamyl transpeptidase-to-platelet ratio (GPR) , which has a high value in the diagnosis of hepatic fibrosis in CHB patients;however, the accuracy of GPR varies between different populations and different areas.GPR is also an excellent predictor for the prognosis of hepatitis B-associated liver cancer.It is pointed out that GPR has a promising future in the diagnosis of hepatic fibrosis in CHB patients, but due to a lack of clinical research data on GPR, further studies are needed to support its application in China.
- hepatitis B,
- chronic,
- liver cirrhosis,
- gamma-glutamyltransferase,
- blood platelets

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References(28)

References

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Association between γ-glutamyl transpeptidase-to-platelet ratio and hepatic fibrosis in patients with chronic hepatitis B

DOI: 10.3969/j.issn.1001-5256.2017.03.034