中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2017
Turn off MathJax
Article Contents

Treatment of HBV/HCV co-infected patients in DAA era

DOI: 10.3969/j.issn.1001-5256.2017.06.001
  • Received Date: 2017-05-17
  • Published Date: 2017-06-20
  • Asian-pacific area, especially China, is Hepatitis B high epidemic area. Since 2011, the first generation of oral direct anti-HCV agents (DAAs) came to clinical use, the treatment of chronic hepatitis C has switched from interferon-based regimen era to DAA era.There is an increased awareness of hepatitis B (HBV) reactivation in chronic hepatitis C (CHC) patients coinfected with HBV treated with pan-oral direct-acting antivirals (DAAs) . Compared with interferon-based regimen, HBV reactivation occurred earlier and more severe among patients received DAA regimen, and even fetal cases or case end up with liver transplantation was reported. Thus, association of liver diseases called to alert the occurrence of HBV reactivation among CHC patients who received DAAs regimen. It is hence important to have HBV serology screened in all CHC patients before initiation of pan-oral DAAs therapy and the usefulness of preemptive administration of effective anti-HBV nucleos (t) ide analogues in coinfected patients need to be further studied.

     

  • loading
  • [1]European Association for Study of Liver.EASL recommendations on treatment of hepatitis C 2015[J].J Hepatol, 2015, 63 (1) :199-236.
    [2]WEI L, LOK AS.Impact of new hepatitis C treatments in different regions of the world[J].Gastroenterology, 2014, 146 (5) :1145-1150.
    [3]YONGHAO G, JIN X, JUN L, et al.An epidemiological serosurvey of hepatitis B virus shows evidence of declining prevalence due to hepatitis B vaccination in central China[J].Int J Infect Dis, 2015, 40:75-80.
    [4]SAGNELLI E, COPPOLA N, PISATURO M, et al.HBV superinfection in HCV chronic carriers:a disease that is frequently severe but associated with the eradication of HCV[J].Hepatology, 2009, 49 (4) :1090-1097.
    [5]KONSTANTINOU D, DEUTSCH M.The spectrum of HBV/HCV coinfection:epidemiology, clinical characteristics, viralinteractions and management[J].Ann Gastroenterol, 2015, 28 (2) :221-228.
    [6]YU G, CHI X, WU R, et al.Replication inhibition of hepatitis B virus and hepatitis C virus in co-infected patients in Chinese population[J].PLo S One, 2015, 10 (9) :e0139015.
    [7]WANG C, JI D, CHEN J, et al.Hepatitis due to reactivation of hepatitis B virus in endemic areas among patients with hepatitis C treated with direct-acting antiviral agents[J].Clin Gastroenterol Hepatol, 2017, 15 (1) :132-136.
    [8]WU JC, CHEN CL, HOU MC, et al.Multiple viral infection as the most common cause of fulminant and subfulminant viral hepatitis in an area endemic for hepatitis B:application and limitations of the polymerase chain reaction[J].Hepatology, 1994, 19 (4) :836-840.
    [9]PONTISSO P, RUVOLETTO MG, FATTOVICH G, et al.Clinical and virological profiles in patients with multiple hepatitis virus infections[J].Gastroenterology, 1993, 105 (5) :1529-1533.
    [10]CHU CM, SHEEN IS, LIAW YF.The role of hepatitis C virus in fulminant viral hepatitis in an area with endemic hepatitis A and B[J].Gastroenterology, 1994, 107 (1) :189-195.
    [11]RAIMONDO G, ALLAIN JP, BRUNETTO MR, et al.Statements from the Taormina expert meeting on occult hepatitis B virus infection[J].J Hepatol, 2008, 49 (4) :652-657.
    [12]CACCIOLA I, POLLICINO T, SQUADRITO G, et al.Occult hepatitis B virus infection in patients with chronic hepatitis C liver disease[J].N Engl J Med, 1999, 341 (1) :22-26.
    [13]CHO LY, YANG JJ, KO KP, et al.Coinfection of hepatitis B and C viruses and risk of hepatocellular carcinoma:systematic review and meta-analysis[J].Int J Cancer, 2011, 128 (1) :176-184.
    [14]OH JK, SHIN HR, LIM MK, et al.Multiplicative synergistic risk of hepatocellular carcinoma development among hepatitis B and C co-infected subjects in HBV endemic area:a community-based cohort study[J].BMC Cancer, 2012, 12:452.
    [15]FONG TL, Di BISCEGLIE AM, WAGGONER JG, et al.The significance of antibody to hepatitis C virus in patients with chronic hepatitis B[J].Hepatology, 1991, 14 (1) :64-67.
    [16]DONATO F, BOFFETTA P, PUOTI M.A meta-analysis of epidemiological studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma[J].Int J Cancer, 1998, 75 (3) :347-354.
    [17]CHIARAMONTE M, STROFFOLINI T, VIAN A, et al.Rate of incidence of hepatocellular carcinoma in patients with compensated viral cirrhosis[J].Cancer, 1999, 85 (10) :2132-2137.
    [18]di BISCEGLIE AM, LOK AS, MARTIN P, et al.Recent US Food and Drug Administration warnings on hepatitis B reactivation with immune-suppressing and anticancer drugs:just the tip of the iceberg?[J].Hepatology, 2015, 61 (2) :703-711.
    [19]HWANG JP, LOK AS.Management of patients with hepatitis B who require immunosuppressive therapy[J].Nat Rev Gastroenterol Hepatol, 2014, 11 (4) :209-219.
    [20]Chinese Society of Hepatology and Chinese Society of Infectious Diseases, Chinese Medical Association.The guideline of prevention and treatment for chronic hepatitis B:a 2015 update[J].J Clin Hepatol, 2015, 31 (12) :1941-1960. (in Chinese) 中华医学会肝病学分会, 中华医学会感染病学分会.慢性乙型肝炎防治指南 (2015年更新版) [J].临床肝胆病杂志, 2015, 31 (12) :1941-1960.
    [21]CHEN G, WANG C, CHEN J, et al.Hepatitis B reactivation in hepatitis B and C coinfected patients treated with antiviral agents:a systematic review and meta-analysis[J].Hepatology, 2017.[Epub ahead of print]
    [22]COLLINS JM, RAPHAEL KL, TERRY C, et al.Hepatitis B virus reactivation during successful treatment of hepatitis C virus with sofosbuvir and simeprevir[J].Clin Infect Dis, 2015, 61 (8) :1304-1306.
    [23]ENDE AR, KIM NH, YEH MM, et al.Fulminant hepatitis B reactivation leading to liver transplantation in a patient with chronic hepatitis C treated with simeprevir and sofosbuvir:a case report[J].J Med Case Rep, 2015, 9:164.
    [24]TAKAYAMA H, SATO T, IKEDA F, et al.Reactivation of hepatitis B virus during interferon-free therapy with daclatasvir and asunaprevir in patient with hepatitis B virus/hepatitis C virus co-infection[J].Hepatol Res, 2016, 46 (5) :489-491.
    [25]HAYASHI K, ISHIGAMI M, ISHIZU Y, et al.A case of acute hepatitis B in a chronic hepatitis C patient after daclatasvir and asunaprevir combination therapy:hepatitis B virus reactivation or acute self-limited hepatitis?[J].Clin J Gastroenterol, 2016, 9 (4) :252-256.
    [26]de MONTE A, COURJON J, ANTY R, et al.Direct-acting antiviral treatment in adults infected with hepatitis C virus:reactivation of hepatitis B virus coinfection as a further challenge[J].J Clin Virol, 2016, 78:27-30.
    [27]PILLAI AA, WEDD J, NORVELL JP, et al.Simeprevir and sofosbuvir (SMV-SOF) for 12 weeks for the treatment of chronic hepatitis C genotype 1 infection:a real world (transplant) hepatology practice experience[J].Am J Gastroenterol, 2016, 111 (2) :250-260.
    [28]GANE EJ, HYLAND RH, AN D, et al.Ledipasvir and sofosbuvir for HCV-infection in patients coinfected with HBV[J].Antivir Ther, 2016, 21 (7) :605-609.
    [29]U.S.Food and Drug Adminstration.FDA Drug Safety Communication:FDA warns about the risk of hepatitis B reactivating in some patients treated with direct-acting antivirals for hepatitis C[EB/OL].[2016-10-4].https://www.fda.gov/Drugs/Drug Safety/ucm 522932.htm.
    [30]YAN LB, RAO HY, MA YJ, et al.Hepatitis B virus infection in Chinese patients with hepatitis C virus infection:prevalence, clinical characteristics, viral interactions and host genotypes:a nationwide cross-sectional study[J].BMJ Open, 2016, 6 (10) :e012016.
    [31]BERSOFF-MATCHA SJ, CAO K, JASON M, et al.Hepatitis B Virus reactivation associated with direct-acting antiviral therapy for chronic hepatitis C virus:a review of cases reported to the U.S.food and drug administration adverse event reporting system[J].Ann Intern Med, 2017.[Epub ahead of print]
    [32]LAU GK, YIU HH, FONG DY, et al.Early is superior to deferred preemptive lamivudine therapy for hepatitis B patients undergoing chemotherapy[J].Gastroenterology, 2003, 125 (6) :1742-1749.
    [33]European Association for the Study of the Liver.EASL recommendations on treatment of hepatitis C 2016[J].J Hepatol, 2017, 66 (1) :153-194.
    [34]European Association for the Study of the Liver.EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection[J].J Hepatol, 2017.[Epub ahead of print]
    [35]OMATA M, KANDA T, WEI L, et al.APASL consensus statements and recommendation on treatment of hepatitis C[J].Hepatol Int, 2016, 10 (5) :702-726.
    [36]SARIN SK, KUMAR M, LAU GK, et al.Asian-Pacific clinical practice guidelines on the management of hepatitis B:a 2015 update[J].Hepatol Int, 2016, 10 (1) :1-98.
    [37]AASLD IDSA HCV Guidance panel.Recommendations for testing, managing, and treating hepatitis C[J/OL].http://www.hcvguidelines.org/full-report/monitoring-patients-who-are-startinghepatitis-c-treatment-are-treatment-or-have.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2234) PDF downloads(575) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return