中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 7
Jul.  2017
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Article Contents

Influence of neutrophil-lymphocyte ratio on prognosis of liver cancer:a meta-analysis

DOI: 10.3969/j.issn.1001-5256.2017.07.020
  • Received Date: 2017-02-04
  • Published Date: 2017-07-20
  • Objective To investigate the association between neutrophil-lymphocyte ratio (NLR) and prognosis of liver cancer.Methods Pub Med, Embase and Cochrane Library, CBM, VIP, Wanfang Data were searched for Chinese and English articles on the association between NLR and prognosis of liver cancer published up to October 2016.Review Manager 5.3 was used for statistical analysis of data in these articles, and funnel plots were used to evaluate publication bias.Results A total of 12 studies which met the inclusion criteria were included, with 3325 liver cancer patients in total.The meta-analysis showed that liver cancer patients with an increased NLR had significant reductions in overall survival time (hazard ratio [HR]=1.56, 95% confidence interval [95% CI]:1.46-1.66, P<0.001) , disease-free survival (HR=1.57, 95% CI:1.23-2.00, P<0.001) , and recurrence-free survival (HR=1.54, 95% CI:1.36-1.74, P<0.001) .Conclusion Liver cancer patients with an increased NLR tend to have poor prognosis, and NLR should be taken seriously in clinical practice to provide timely prognostic evaluation and rational treatment for liver cancer patients.

     

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