Some achievements have been made in the research on liver diseases in children in China, with the help of several generations of physicians for 60 years. At present, liver biopsy, examination of duodenal fluid and bile, screening for inherited metabolic diseases, and new techniques of genetic diagnosis have been conducted in China. Planned immunization with hepatitis A and B vaccines significantly reduces the incidence rates of hepatitis A and B. Remarkable achievements have been obtained in the research on cytomegalovirus infection, cytomegalovirus hepatitis, nonalcoholic fatty liver disease, autoimmune liver diseases, and drug-induced liver disease. Intensive research on liver diseases in children in China may gradually narrow the gap between China and developed countries in future.