中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 10
Oct.  2017
Turn off MathJax
Article Contents

Etiology of pediatric acute liver failure

DOI: 10.3969/j.issn.1001-5256.2017.10.016
  • Received Date: 2017-07-14
  • Published Date: 2017-10-20
  • Pediatric acute liver failure ( PALF) is a complex syndrome with rapid progression, and the cause of PALF is age-dependent.This article analyzes the common causes of PALF in clinical practice, including infection factors, inherited metabolic factors, poisoning and drugs, abnormal perfusion, and autoimmune diseases, among which infection factors are the most common cause. With the improvement in diagnosis and treatment techniques, the diagnostic rate of PALF caused by inherited metabolic diseases and autoimmune diseases keeps increasing. Due to the small number of PALF patients, there lacks experience in etiological diagnosis. This article summarizes related reports, in order to provide a reference for screening the causes of PALF.

     

  • loading
  • [1]LEE WS, MCKIERNAN P, KELLY DA.Etiology, outcome and prognostic indicators of childhood fulminant hepatic failure in the U-nited Kingdom[J].J Pediatr Gastroenterol Nutr, 2005, 40 (5) :575-581.
    [2] WANG JS, FU HY.Progress on acute liver failure in children-Asummary of the 9th National Conference of Pediatric Hepatology[J].Chin J Clin Infect Dis, 2009, 2 (3) :190-192. (in Chinese) 王建设, 傅海燕.儿童急性肝衰竭若干研究进展---记第九次全国儿科肝病学术会议[J].中华临床感染病杂志, 2009, 2 (3) :190-192.
    [3]SQUIRES RH Jr, SHNEIDER BL, BUCUVALAS J, et al.Acute liver failure in children:the first 348 patients in the pediatric acute liver failure study group[J].J Pediatr, 2006, 148 (5) :652-658.
    [4]SUCHY FJ, SOKOL RJ, BALISTRERI WF.Liver disease in children[M].3rd ed.New York:Cambridge University Press, 2007.
    [5]KATHEMANN S, BECHMANN LP, SOWA JP, et al.Etiology, outcome and prognostic factors of childhood acute liver failure in a German Single Center[J].Ann Hepatol, 2015, 14 (5) :722-728.
    [6]ALAM S, KHANNA R, SOOD V, et al.Profile and outcome of first109 cases of paediatric acute liver failure at a specialized paediatric liver unit in India[J].Liver Int, 2017.[Epub ahead of print]
    [7]MAZUMDER MW, KARIM AB, RUKUNUZZAMAN M, et al.Aetiology and outcome of acute liver failure in children:experience at a tertiary care hospital of bangladesh[J].Mymensingh Med J, 2016, 25 (3) :492-494.
    [8]DHAWAN A.Acute liver failure in children and adolescents[J].Clin Res Hepatol Gastroenterol, 2012, 36 (3) :278-283.
    [9]FU HY, WANG XM, WANG YL, et al.Analysis of etiology and biochemical markers of acute liver failure in children[J].J Clin Pediatr, 2015, 33 (10) :841-845. (in Chinese) 付海燕, 王晓明, 王亚利, 等.儿童急性肝衰竭病因及生化指标分析[J].临床儿科杂志, 2015, 33 (10) :841-845.
    [10]NEWLAND CD.Acute liver failure[J].Pediatr Ann, 2016, 45 (12) :e433-e438.
    [11]CIOCCA M, LVAREZ F.Neonatal acute liver failure:a diagnosis challenge[J].Arch Argent Pediatr, 2017, 115 (2) :175-180.
    [12]KAYAALP C, ERSAN V, YILMAZ S.Acute liver failure in Turkey:a systematic review[J].Turk J Gastroenterol, 2014, 25 (1) :35-40.
    [13]ZAY F, KARADAGˇNCEL E, BARIS Z, et al.Etiologies, outcomes, and prognostic factors of pediatric acute liver failure:a single center's experience in Turkey[J].Turk J Gastroenterol, 2016, 27 (5) :450-457.
    [14]SCHWARZ KB, OLIO DD, LOBRITTO SJ, et al.Analysis of viral testing in nonacetamino-phen pediatric acute liver failure[J].JPediatr Gastroenterol Nutr, 2014, 59 (5) :616-623.
    [15]MCKIERNAN P, BALL S, SANTRA S, et al.Incidence of primary mitochondrial disease in children younger than 2 years presenting with acute liver failure[J].J Pediatr Gastroenterol Nutr, 2016, 63 (6) :592-597.
    [16]BINDI V, EIROA H.Citrullinemia type I with recurrent liver failure in a child[J].Arch Argent Pediatr, 2017, 115 (1) :e39-e42.
    [17]ALAM S, LAL BB.Metabolic liver diseases presenting as acute liver failure in children[J].Indian Pediatr, 2016, 53 (8) :695-701.
    [18]European Association for Study of Liver.EASL clinical practice guideline:Wilson's disease[J].J Hepatol, 2012, 56 (3) :671-685.
    [19]TIAN Y, GONG GZ, YANG X, et al.Diagnosis and management of fulminant Wilson's disease:a single center's experience[J].World J Pediatr, 2016, 12 (2) :209-214.
    [20]BHATTACHARYA K.Investigation and management of the hepatic glycogen storage diseases[J].Transl Pediatr, 2015, 4 (3) :240-248.
    [21]ZHANG MH, GONG JY, WANG JS.Citrin deficiency presenting as acute liver failure in an eight-month-old infant[J].World J Gastroenterol, 2015, 21 (23) :7331-7334.
    [22]SRIVASTAVA A.Progressive familial intrahepatic cholestasis[J].J Clin Exp Hepatol, 2014, 4 (1) :25-36.
    [23]LONG YJ, AGNES ROTIG, WANG JS.Acute liver failure caused by GFM1 mutations in a child:the relationship between GFM1 missense mutation and the peripheral amino acid and the change of clinical phenotype[J].Chin J Evid Based Pediatr, 2016, 11 (5) :369-372. (in Chinese) 龙艺杰, Agnes Rotig, 王建设.GFM1突变所致儿童急性肝衰竭1例:质疑GFM1错义突变位置决定临床表型[J].中国循证儿科杂志, 2016, 11 (5) :369-372.
    [24]KORTM F, MARQUARDT I, ALAWI M, et al.Acute liver failure meets SOPH syndrome:a case report on an intermediate phenotype[J].Pediatrics, 2017, 139 (1) .pii:e20160550.
    [25]ALONSO EM, JAMES LP, ZHANG S, et al.Acetaminophen adducts detected in serum of pediatric patients with acute liver failure[J].J Pediatr Gastroenterol Nutr, 2015, 61 (1) :102-107.
    [26]AL-SINANI S, AL-RAWAS A, DHAWAN A.Mercury as a cause of fulminant hepatic failure in a child:case report and literature review[J].Clin Res Hepatol Gastroenterol, 2011, 35 (8-9) :580-582.
    [27]DI GIORGIO A, BRAVI M, BONANOMI E, et al.Fulminant hepatic failure of autoimmune aetiology in children[J].J Pediatr Gastroenterol Nutr, 2015, 60 (2) :159-164.
    [28]NARKEWICZ MR, HORSLEN S, BELLE SH, et al.Prevalence and significance of autoantibodies in children with acute liver failure[J].J Pediatr Gastroenterol Nutr, 2017, 64 (2) :210-217.
    [29]SHI CH, JING YH.Seven cases of Reyes syndrome[J].Chin Pediatr Emerg Med, 2010, 17 (2) :151-152. (in Chinese) 史春华, 景玉华.瑞氏综合征七例临床分析[J].中国小儿急救医学, 2010, 17 (2) :151-152.
    [30]WHARTON M, CHORBA TL, VOGT RL, et al.Case definitions for public health surveillance[J].MMWR Recomm Rep, 1990, 39 (RR-13) :1-43.
    [31]HALL SM, PLASTER PA, GLASGOW JF, et al.Preadmission antipyretics in Reye's syndrome[J].Arch Dis Child, 1988, 63 (7) :857-866.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2378) PDF downloads(417) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return