Research advances in the diagnosis of nonalcoholic fatty liver disease in children

Li Jing; Qi LingLi; Wu Jie

doi:10.3969/j.issn.1001-5256.2017.10.038

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Oct. 2017

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Article Navigation > Journal of Clinical Hepatology > 2017 > 33(10): 2025-2029

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Research advances in the diagnosis of nonalcoholic fatty liver disease in children

DOI: 10.3969/j.issn.1001-5256.2017.10.038

Department of Pediatric Gastroenterology, Shengjing Hospital of China Medical University

Received Date: 2017-05-22
Published Date: 2017-10-20

Abstract

Abstract

Nonalcoholic fatty liver disease ( NAFLD) has become one of the most common chronic liver diseases in children. Since the clinical manifestations of NAFLD lack specificity, the diagnosis of this disease is mainly based on clinical symptoms and auxiliary examinations.Serum liver enzymes, blood lipid levels and homeostasis model assessment of insulin resistance are commonly used in clinical practice, and cytokeratin-18, triglyceride glucose index may become new markers for the diagnosis of NAFLD in children. Imaging examinations such as ultrasound, magnetic resonance imaging and computed tomography have their own limitations in the diagnosis of NAFLD in children, while controlled attenuation parameter and acoustic radiation force impulse may have a high value in future. The scoring systems for NAFLD need to be validated by clinical research. At present, liver biopsy remains the“gold standard”for the diagnosis of NAFLD in children. This article summarizes the latest research advances in NAFLD in children and discusses the diagnostic values of laboratory markers and imaging examinations.
- fatty liver,
- diagnosis,
- child,
- review

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References(42)

References

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Research advances in the diagnosis of nonalcoholic fatty liver disease in children

DOI: 10.3969/j.issn.1001-5256.2017.10.038

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Research advances in the diagnosis of nonalcoholic fatty liver disease in children

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