Chronic hepatitis caused by hepatitis C virus (HCV) infection is one of the leading causes of liver cirrhosis and hepatocellular carcinoma.In recent years, direct-acting antiviral agents (DAAs) have gradually become main drugs for the treatment of hepatitis C.Studies have shown that DAAs may increase the risk of the development or recurrence of liver cancer in patients with HCV-related liver cirrhosis, which causes great controversies over the clinical application of DAAs.This article reviews the influence of DAAs on the development and recurrence of liver cancer, in order to provide a better basis for the clinical application of DAAs.
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