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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 7
Jul.  2018
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Article Contents

Analysis of reversal factors associated with liver fibrosis/cirrhosis in patients with chronic HBV infection after achieving virologic response

DOI: 10.3969/j.issn.1001-5256.2018.07.038
  • Received Date: 2017-12-11
  • Published Date: 2018-07-20
  • Chronic hepatitis B virus ( HBV) infection can lead to varying degrees of liver fibrosis, which is an important pathological basis of liver cirrhosis. The incidence of end-stage liver diseases such as liver cirrhosis and hepatocellular carcinoma can be reduced by controlling and even reversing liver fibrosis. After achieving virologic response ( VR) to long-term anti-HBV therapy, patients with chronic HBV infection have resolution of inflammation, varying degrees of reversal of liver fibrosis and even liver cirrhosis, or even complete recovery of normal liver structure, but the specific mechanism and influencing factors remain unclear. This article reviews the recent studies on the reversal of liver fibrosis/cirrhosis after achieving VR in patients with chronic HBV infection, and summarizes the influencing factors for reversal of liver fibrosis/cirrhosis in patients with chronic HBV infection after antiviral therapy, including age, sex, host factors, viral factors, therapeutic factors, and metabolic factors, but a lot of factors still await further investigation.

     

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