|
[1]MAKAROVA-RUSHER OV, MEDINA-ECHEVERZ J, DUFFY AG, et al.The yin and yang of evasion and immune activation in HCC[J].J Hepatol, 2015, 62 (6) :1420-1429.
|
|
[2]VILLAR S, ORITZ-CUARAN S, ABEDI-ARDEKANI B, et al.Aflatoxin-induced TP53 R249S mutation in hepatocellular carcinoma in Thailand:Association with tumors developing in the absence of liver cirrhosis[J].PLo S One, 2012, 7 (6) :e37707.
|
|
[3] EL-SERAG HB.Hepatocellular carcinoma[J].N Engl J Med, 2011, 365 (12) :1118-1127.
|
|
[4] DIXON LJ, BARNES M, TANG H, et al.Kupffer cells in the liver[J].Compr Physiol, 2013, 3 (2) :785-797.
|
|
[5]CARAMBIA A, FREUND B, SCHWINGE D, et al.TGF-β-dependent induction of CD4+CD25+Foxp3+Tregs by liver sinusoidal endothelial cells[J].J Hepatol, 2014, 61 (3) :594-599.
|
|
[6]BOTTCHER JP, SCHANZ O, WOHLLEBER D, et al.Liverprimed memory T cells generated under noninflammatory conditions provide anti-infectious immunity[J].Cell Rep, 2013, 3 (3) :779-795.
|
|
[7]KNOLLE PA, GERMANN T, TREICHEL U, et al.Endotoxin downregulates T cell activation by antigen-presenting liver sinusoidal endothelial cells[J].J Immunol, 1999, 162 (3) :1401-1407.
|
|
[8]MUHLBAUER M, FLECK M, SCHUTZ C, et al.PD-L1 is induced in hepatocytes by viral infection and by interferon-alpha and-gamma and mediates T cell apoptosis[J].J Hepatol, 2006, 45 (4) :520-528.
|
|
[9]XIA Y, CHEN R, YE SL, et al.Inhibition of T-cell responses by intratumoral hepatic stellate cells contribute to migration and invasion of hepatocellular carcinoma[J].Clin Exp Metastasis, 2011, 28 (7) :661-674.
|
|
[10]DIEHL L, SCHURICH A, GROCHTMANN R, et al.Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+T cell tolerance[J].Hepatology, 2008, 47 (1) :296-305.
|
|
[11]KASSEL R, CRUISE MW, IEZZONI JC, et al.Chronically inflamed livers up-regulate expression of inhibitory B7 family members[J].Hepatology, 2009, 50 (5) :1625-1637.
|
|
[12]GU X, WANG Y, XIANG J, et al.Interferon-γtriggers hepatic stellate cell-mediated immune regulation through MEK/ERK signaling pathway[J].Clin Dev Immunol, 2013, 2013:389807.
|
|
[13]LI W, KUHR CS, ZHENG XX, et al.New insights into mechanisms of spontaneous liver transplant tolerance:The role of Foxp3-expressing CD25+CD4+regulatory T cells[J].Am J Transplant, 2008, 8 (8) :1639-1651.
|
|
[14]GAO HJ, ZHANG YJ, LIANG HH, et al.Radiofrequency ablation does not induce the significant increase of CD4+CD25+Foxp3+regulatory T cells compared with surgical resection in Hepal-6 tumor model[J].Arch Immunol Ther Exp (Warsz) , 2013, 61 (4) :333-340.
|
|
[15]ZHANG HH, MEI MH, FEI R, et al.Regulatory T cells in chronic hepatitis B patients affect the immunopathogenesis of hepatocellular carcinoma by suppressing the anti-tumour immune responses[J].J Viral Hepat, 2010, 17 (Suppl 1) :34-43.
|
|
[16]ZHAO HQ, LI WM, LU ZQ, et al.Roles of Tregs in development of hepatocellular carcinoma:A meta-analysis[J].World J Gastroenterol, 2014, 20 (24) :7971-7978.
|
|
[17]ORMANDY LA, HILLEMANN T, WEDEMEYER H, et al.Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma[J].Cancer Res, 2005, 65 (6) :2457-2464.
|
|
[18]UNITT E, RUSHBROOK SM, MARSHALL A, et al.Compromised lymphocytes infiltrate hepatocellular carcinoma:The role of T-regulatory cells[J].Hepatology, 2005, 41 (4) :722-730.
|
|
[19]TU JF, DING YH, YING XH, et al.Regulatory T cells, especially ICOS+FOXP3+regulatory T cells, are increased in the hepatocellular carcinoma microenvironment and predict reduced survival[J].Sci Rep, 2016, 6:35056.
|
|
[20]ZHANG HH, MEI MH, FEI R, et al.Regulatory T cell depletion enhances tumor specific CD8 T-cell responses, elicited by tumor antigen NY-ESO-1b in hepatocellular carcinoma patients, in vitro[J].Int J Oncol, 2010, 36 (4) :841-848.
|
|
[21]BARRA MM, RICHARDS DM, HOFER AC, et al.Premature expression of Foxp3 in double-negative thymocytes[J].PLo S One, 2015, 10 (5) :e0127038.
|
|
[22]BEYER M, CLASSEN S, ENDL E, et al.Comparative approach to define increased regulatory T cells in different cancer subtypes by combined assessment of CD127 and FOXP3[J].Clin Dev Immunol, 2011, 2011:734036.
|
|
[23]KAKITA N, KANTO T, ITOSE I, et al.Comparative analyses of regulatory T cell subsets in patients with hepatocellular carcinoma:A crucial role of CD25-FOXP3-T cells[J].Int J Cancer, 2012, 131 (11) :2573-2583.
|
|
[24]HAO WB, XIANG FF, LIU QL, et al.Research advances of myeloid inhibitory cells in tumor microenvironment[J].Immunol J, 2017, 33 (8) :729-732. (in Chinese) 郝文斌, 相芬芬, 刘巧丽, 等.髓源抑制细胞在肿瘤微环境中的研究进展[J].免疫学杂志, 2017, 33 (8) :729-732.
|
|
[25]HAILE LA, GAMREKELASHVILI J, MANNS MP, et al.CD49d is a new marker for distinct myeloid-derived suppressor cell subpopulations in mice[J].J Immunol, 2010, 185 (1) :203-210.
|
|
[26]HOECHST B, ORMANDY LA, BALLMAIER M, et al.A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4+CD25+Foxp3+T cells[J].Gastroenterology, 2008, 135 (1) :234-243.
|
|
[27]CHIU DK, XU IM, LAI RK, et al.Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26[J].Hepatology, 2016, 64 (3) :797-813.
|
|
[28]XU Y, ZHAO W, XU J, et al.Activated hepatic stellate cells promote liver cancer by induction of myeloid-derived suppressor cells through cyclooxygenase-2[J].Oncotarget, 2016, 7 (8) :8866-8878.
|
|
[29]KAPANADZE T, GAMREKELASHVILI J, MA C, et al.Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma[J].J Hepatol, 2013, 59 (5) :1007-1013.
|
|
[30]DENG Y, CHENG J, FU B, et al.Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells[J].Oncogene, 2017, 36 (8) :1090-1101.
|
|
[31]SICA A, MANTOVANI A.Macrophage plasticity and polarization:In vivo veritas[J].J Clin Invest, 2012, 122 (3) :787-795.
|
|
[32]BISWAS SK, MANTOVANI A.Macrophage plasticity and interaction with lymphocyte subsets:Cancer as a paradigm[J].Nat Immunol, 2010, 11 (10) :889-896.
|
|
[33]JEANNIN P, PAOLINI L, ADAM C, et al.The roles of CSFs on the functional polarization of tumor-associated macrophages[J].FEBS J, 2018, 285 (4) :680-699.
|
|
[34]SAWA-WEJKSZA K, KANDEFER-SZERSZEN'M.Tumor-associated macrophages as target for antitumor therapy[J].Arch Immunol Ther Exp (Warsz) , 2018, 66 (2) :97-111.
|
|
[35] GABRILOVICH DI, NAQARAJ S.Myeloid-derived suppressor cells as regulators of the immune system[J].Nat Rev Immunol, 2009, 9 (3) :162-174.
|
|
[36]TAKAI H, HATO A, KATO C, et al.The expression profile of glypican-3 and its relation to macrophage population in human hepatocellular carcinoma[J].Liver Int, 2009, 29 (7) :1056-1064.
|
|
[37]WAN S, ZHAO E, KRYCZEK I, et al.Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells[J].Gastroenterology, 2014, 147 (6) :1393-1404.
|
|
[38]MANO Y, AISHIMA S, FUJITA N, et al.Tumor-associated macrophage promotes tumor progression via STAT3 signaling in hepatocellular carcinoma[J].Pathobiology, 2013, 80 (3) :146-154.
|
|
[39]YANG W, LU Y, XU Y, et al.Estrogen represses hepatocellular carcinoma (HCC) growth via inhibiting alternative activation of tumor-associated macrophages (TAMs) [J].J Biol Chem, 2012, 287 (48) :40140-40149.
|
|
[40]NAUGLER WE, SAKURAI T, KIM S, et al.Gender disparity in liver cancer due to sex differences in My D88-dependent IL-6 production[J].Science, 2007, 317 (5834) :121-124.
|
|
[41]DENG YR, LIU WB, LIAN ZX, et al.Sorafenib inhibits macrophage-mediated epithelial-mesenchymal transition in hepatocellular carcinoma[J].Oncotarget, 2016, 7 (25) :38292-38305.
|
|
[42]YANG H, ZHANG S, XIN YF.Research progress on immunotherapy in treating cancer[J].Chin J Clin Pharmacol Ther, 2016, 21 (9) :1074-1080. (in Chinese) 杨何, 张升, 辛艳飞.肿瘤免疫治疗研究进展[J].中国临床药理学与治疗学, 2016, 21 (9) :1074-1080.
|
|
[43]HAN Y, CHEN Z, YANG Y, et al.Human CD14+CTLA-4+regulatory dendritic cells suppress T-cell response by cytotoxic Tlymphocyte antigen-4-dependent IL-10 and indoleamine-2, 3-dioxygenase production in hepatocellular carcinoma[J].Hepatology 2014, 59 (2) :567-579.
|
|
[44]CHU CC, ALI N, KARAGIANNIS P, et al.Resident CD141 (BDCA3) +dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation[J].J Exp Med, 2012, 209 (5) :935-945.
|
|
[45]WU P, WU D, LI L, et al.PD-L1 and survival in solid tumors:A meta-analysis[J].PLo S One, 2015, 10 (6) :e0131403.
|
|
[46]NAKAMOTO N, CHO H, SHAKED A, et al.Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade[J].PLo S Pathog, 2009, 5 (2) :e1000313.
|
|
[47]NAKAMOTO N, KAPLAN DE, COLECLOUGH J, et al.Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization[J].Gastroenterology, 2008, 134 (7) :1927-1937.
|
DownLoad: