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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 7
Jul.  2018
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Article Contents

Research advances in glucocorticoids for the treatment of liver failure

DOI: 10.3969/j.issn.1001-5256.2018.07.043
  • Received Date: 2017-12-26
  • Published Date: 2018-07-20
  • Glucocorticoids ( GCs) are widely used in the treatment of liver diseases accompanied by inflammation due to its strong anti-inflammatory and immunosuppressive effects, especially autoimmune hepatitis and cholestatic hepatitis. However, there are still controversies over the use of GCs in the treatment of liver failure among Chinese and foreign scholars. On the one hand, some scholars think that GCs can suppress immune function, cause immune dysfunction, induce bacterial and fungal infections, and thus increase mortality; on the other hand, some scholars believe that GCs can suppress immune response, reduce inflammatory response and hepatocyte necrosis, and thus protect hepatocytes and prolong survival. This article reviews the mechanism, opportune administration, and dosage of GCs in the treatment of liver failure, as well as the current status of the research on the application of GCs in liver failure of different etiologies and observation indices during application.

     

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