[1]WANG Q, LIU J, YANG DL.Innate immune response and acquired immune response in patients with chronic HBV infection[J].J Clin Hepatol, 2016, 32 (10) :1863-1869. (in Chinese) 王琴, 刘嘉, 杨东亮.慢性HBV感染的天然免疫与获得性免疫应答[J].临床肝胆病杂志, 2016, 32 (10) :1863-1869.
|
[2]WU J, SUN L, CHEN X, et al.Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA[J].Science, 2013, 339 (6121) :827-830.
|
[3]NASSAL M.HBV ccc DNA:Viral persistence reservoir and key obstacle for a cure of chronic hepatitis B[J].Gut, 2015, 64 (12) :1972-1984.
|
[4]HOLM CK, PALUDAN SR, FITZGERALD KA.DNA recognition in immunity and disease[J].Curr Opin Immunol, 2013, 25 (1) :13-18.
|
[5]SAUER JD, SOTELOTROHA K, VON MJ, et al.The N-ethylN-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides[J].Infect Immun, 2011, 79 (2) :688-694.
|
[6]BURDETTE DL, MONROE KM, SOTELOTROHA K, et al.STING is a direct innate immune sensor of cyclic-di-GMP[J].Nature, 2011, 478 (7370) :515-518.
|
[7]CONLON J, BURDETTE DL, SHARMA S, et al.Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5, 6-dimethylxanthenone-4-acetic acid[J].J Immunol, 2013, 190 (10) :5216-5225.
|
[8]TANER C, TOBIAS D, ABLASSER A, et al.Species-specific detection of the antiviral small-molecule compound CMA by STING[J].EMBO J, 2013, 32 (10) :1440-1450.
|
[9]CIVRIL F, DEIMLING T, de OLIVEIRA MANN CC, et al.Structural mechanism of cytosolic DNA sensing by c GAS[J].Nature, 2013, 498 (7454) :332-337.
|
[10]CAI X, CHIU YH, CHEN ZJ.The c GAS-c GAMP-STING pathway of cytosolic DNA sensing and signaling[J].Mol Cell, 2014, 54 (2) :289-296.
|
[11]KIM S, LI L, MALIGA Z, et al.Anticancer flavonoids are mouse-selective STING agonists[J].ACS Chem Biol, 2013, 8 (7) :1396-1401.
|
[12]CHIN KH, TU ZL, SU YC, et al.Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING[J].Acta Crystallogr D Biol Crystallogr, 2013, 69 (Pt 3) :352-366.
|
[13]OUYANG S, SONG X, WANG Y, et al.Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding[J].Immunity, 2012, 36 (36) :1073-1086.
|
[14]SHU C, YI G, WATTS T, et al.Structure of STING bound to cdi-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system[J].Nat Struct Mol Biol, 2012, 19 (7) :722-724.
|
[15]ELIE J, DINER, DARA L, et al.The innate immune DNA sensor c GAS produces a non-canonical cyclic-di-nucleotide that activates human STING[J].Cell Rep, 2013, 3 (5) :1355-1361.
|
[16]ZHANG X, SHI H, WU J, et al.Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high affinity ligand for STING[J].Mol Cell, 2015, 51 (2) :226-235.
|
[17]BARKER JR, KOESTLER BJ, CARPENTER VK, et al.STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during chlamydia trachomatis infection[J].MBio, 2013, 4 (3) :e00018-13.
|
[18]WIELAND S, THIMME R, PURCELL RH, et al.Genomic analysis of the host response to hepatitis B virus infection[J].Proc Natl Acad Sci U S A, 2004, 101 (17) :6669-6674.
|
[19]WIELAND SF, CHISARI FV.Stealth and cunning:Hepatitis B and hepatitis C viruses[J].J Virol, 2005, 79 (15) :9369-9380.
|
[20]CHRISTEN V, DUONG F, BERNSMEIER C, et al.Inhibition of alpha interferon signaling by hepatitis B virus[J].J Virol, 2007, 81 (1) :159-165.
|
[21]VISVANATHAN K, SKINNER NA, THOMPSON AJ, et al.Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein[J].Hepatology, 2007, 45 (1) :102-110.
|
[22]CHEN Z, CHENG Y, XU Y, et al.Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients[J].Clin Immunol, 2008, 128 (3) :400-408.
|
[23]OLIVIERO B, VARCHETTA S, PAUDICE E, et al.Natural killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infections[J].Gastroenterology, 2009, 137 (3) :1151-1160.
|
[24]GUO F, HAN Y, ZHAO X, et al.STING agonists induce an innate antiviral immune response against hepatitis B virus[J].Antimicrob Agents Chemother, 2015, 59 (2) :1273-1281.
|
[25]DANSAKO H, UEDA Y, OKUMURA N, et al.The cyclic GMPAMP synthetase-STING signaling pathway is required for both the innate immune response against HBV and the suppression of HBV assembly[J].FEBS J, 2016, 283 (1) :144-156.
|
[26]GAO D, WU J, WU YT, et al.Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses[J].Science, 2013, 341 (6148) :903-906.
|
[27]LIU Y, LI J, CHEN J, et al.Hepatitis B virus polymerase disrupts K63-linked ubiquitination of STING to block innate cytosolic DNA-sensing pathways[J].J Virol, 2014, 89 (4) :2287-2300.
|
[28]YIM SA, HEYDMANN L, VERRIER E, et al.The CGAS-sting pathway exhibits antiviral activity against hepatitis B virus infection[J].J Hepatol, 2016, 64 (2) :s396.
|
[29]HE J, HAO R, LIU D, et al.Inhibition of hepatitis B virus replication by activation of the c GAS-STING pathway[J].J Gen Virol, 2016, 97 (12) :3368-3378.
|
[30]HOSEL M, QUASDORFF M, WIEGMANN K, et al.Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection[J].Hepatology, 2009, 50 (6) :1773-1782.
|
[31]LIU Y, LI J, CHEN J, et al.Hepatitis B virus polymerase disrupts K63-linked ubiquitination of STING to block innate cytosolic DNA-sensing pathways[J].J Virol, 2015, 89 (4) :2287-2300.
|
[32]THOMSEN MK, NANDAKUMAR R, STADLER D, et al.Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection[J].Hepatology, 2016, 64 (3) :746-759.
|
[33]LI FL, HUA J, LU YP, et al.Research advances in innate immunity against hepatitis B virus[J].J Clin Hepatol, 2016, 32 (5) :992-996. (in Chinese) 李凤莉, 华娟, 卢银平, 等.HBV感染天然免疫的研究进展[J].临床肝胆病杂志, 2016, 32 (5) :992-996.
|