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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 8
Aug.  2018
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Article Contents

The association between type 2 diabetes mellitus and hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2018.08.045
  • Received Date: 2018-01-29
  • Published Date: 2018-08-20
  • Type 2 diabetes mellitus ( T2 DM) is closely associated with the development of hepatocellular carcinoma ( HCC) . T2 DM can increase the risk of HCC in many ways, which suggests that several signaling pathways or susceptibility genes might be involved in the development of these two diseases. This article discusses the role of T2 DM in the development of HCC and the association between T2 DM and HCC at genetic and molecular levels and finds that nuclear receptor co-activator 5, transcription factor 7-like 2, glycogen synthase kinase 3β, and Toll-like receptor 4 are involved in the pathogenesis of T2 DM and HCC, which is the key that links the two diseases at genetic and molecular levels.

     

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