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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 9
Sep.  2018
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Article Contents

Research advances in acute liver failure

DOI: 10.3969/j.issn.1001-5256.2018.09.002
  • Received Date: 2018-06-21
  • Published Date: 2018-09-20
  • Acute liver failure (ALF) is a syndrome characterized by rapid onset, rapid progression, and poor prognosis. Although much progress has been achieved in the etiology and pathogenesis of ALF and emergency liver transplantation and comprehensive treatment have significantly increased the treatment success rate, there are still many difficult issues in clinical practice. This article reviews the research advances in the classification, etiology, main clinical types, prognostic scoring system, and treatment of ALF in recent years.

     

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  • [1]LEE WM, LARSON AM, STRAVITZ RT.AASLD position paper:The management of acute liver failure:Update 2011[J].Hepatology, 2011, 55:1-22.
    [2]European Association for the Study of the Liver.EASL clinical practical guidelines on the management of acute (fulminant) liver failure[J].J Hepatol, 2017, 66 (5) :1047-1081.
    [3]HERRINE SK, MOAYYEDI P, BROWN RS Jr, et al.American Gastroenterological Association Institute technical review on initial testing and management of acute liver disease[J].Gastroenterology, 2017, 52 (3) :648-664.e5.
    [4]WANG YM, YAN GH.A new understanding of the typing and diagnosis of liver failure[J].J Inter Intens Med, 2016, 22 (3) :161-166. (in Chinese) 王宇明, 闫国华.肝衰竭分型机制及诊断研究的新认识[J].内科急危重症杂志, 2016, 22 (3) :161-166.
    [5]BERNAL W, HYYRYLAINEN A, GERA A, et al.Lessons from look-back in acute liver failure?A single centre experience of 3300 patients[J].J Hepatol, 2013, 59 (1) :74-80.
    [6]FONTANA RJ, ELLERBE C, DURKALSKI VE, et al.2-year outcomes in initial survivors with acute liver failure:Results from a prospective, multicenter study[J].Liver Int, 2015, 35 (2) :370-380.
    [7]ESCORSELL A, MAS A, de la MATA M, et al.Acute liver failure in Spain:Analysis of 267 cases[J].Liver Transpl, 2007, 13 (10) :1389-1395.
    [8]TREY C, DAVIDSON CS.The management of fulminant hepatic failure[J].Prog Liver Dis, 1970, 3 (3) :282-298.
    [9]BERNUAU J, RUEFF B, BENHAMOU JP.Fulminant and subfulminant liver failure:Definitions and causes[J].Semin Liver Dis, 1986, 6 (2) :97-106.
    [10]O'GRADY JG, SCHALM SW, WILLIAMS R.Acute liver failure:Redefining the syndromes[J].Lancet, 1993, 342 (8866) :273-275.
    [11]TANDON BN, BERNAUAU J, O'GRADY J, et al.Recommendations of the International Association for the Study of the Liver Subcommittee on nomenclature of acute and subacute liver failure[J].JGastroenterol Hepatol, 1999, 14 (5) :403-404.
    [12]MOCHIDA S, TAKIKAWA Y, NAKAYAMA N, et al.Diagnostic criteria of acute liver failure:A report by the intractable hepatobiliary diseases study group of Japan[J].Hepatol Res, 2011, 41 (9) :805-812.
    [13] Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association;Severe Liver Diseases and Artificial Liver Group, Chinese Society of Hepatology, Chinese Medical Association.Guidelines for diagnosis and treatment liver failure[J].Chin J Clin Infect Dis, 2012, 5 (6) :321-327. (in Chinese) 中华医学会感染病学分会肝衰竭与人工肝学组, 中华医学会肝病学分会重型肝病与人工肝学组.肝衰竭诊治指南 (2012年版) [J].中华临床感染病杂志, 2012, 5 (6) :321-327.
    [14]MANKA P, VERHEYEN J, GERKEN G, et al.Liver failure due to acute viral hepatitis (A-E) [J].Visc Med, 2016, 32 (5) :80-85.
    [15]ZHAO P, WANG CY, LIU WW, et al.Causes and outcomes of acute liver failure in China[J].PLo S One, 2013, 8 (11) :e80991.
    [16]WANG CY, ZHAO P, LIU WW, et al.Acute liver failure caused by severe acute hepatitis B:A case series from a multi-center investigation[J].Ann Clin Microbiol Antimicrob, 2014, 13:23.
    [17]FUJIWARA K, YOKOSUKA O, EHATA T, et al.Association between severity of type A hepatitis and nucleotide variations in the 50non-translated region of hepatitis A virus RNA:strains from fulminant hepatitis have fewer nucleotide substitutions[J].Gut, 2002, 51 (1) :82-88.
    [18]LIU XY, CHEN J, WANG XX, et al.Etiological analysis of 3233 patients with acute liver failure, subacute liver failure and acute-onchronic liver failure[J].Clin Med Engineering, 2012, 19 (5) :823-825. (in Chinese) 刘晓燕, 陈婧, 王晓霞, 等.3233例急性、亚急性、慢加急性肝衰竭病因特点分析[J].临床医学工程, 2012, 19 (5) :823-825.
    [19]NING GX, LI L, HOU JL, et al.Etiology and clinical features of acute-on-chronic liver failure and their association with prognosis[J].Hebei Med J, 2017, 39 (2) :214-216. (in Chinese) 宁更献, 李力, 侯军良, 等.慢加急性肝衰竭病因、临床特点与预后关系分析[J].河北医药, 2017, 39 (2) :214-216.
    [20]SEBASTIANI M, ATZENI F, MILAZZO L, et al.Italian consensus guidelines for the management of hepatitis B virus infections in patients with rheumatoid arthritis[J].Joint Bone Spine, 2017, 84 (5) :525-530.
    [21]PATTULLO V.Prevention of hepatitis B reactivation in the setting of immunosuppression[J].Clin Mol Hepatol, 2016, 22 (2) :219-237.
    [22]CALLE SERRANO B, GRO HENNIG A, HOMS M, et al.Development and evaluation of a baseline-event-anticipation score for hepatitis delta[J].J Viral Hepat, 2014, 21 (11) :e154-163.
    [23]ARENDS J, GHISETTI V, IRVING W, et al.Hepatitis E:An emerging infection in high income countries[J].J Clin Virol, 2014, 59 (2) :81-88.
    [24]SHARMA S, KUMAR A, KAR P, et al.Risk factors for vertical transmission of hepatitis E virus infection[J].J Viral Hepat, 2017, 24 (11) :1067-1075.
    [25]REUBEN A, KOCH DG, LEE WM, et al.Drug induced acute liver failure:Results of a U.S.multicenter, prospective study[J].Hepatology, 2010, 52 (6) :2065-2076.
    [26]FORREST JA, CLEMENTS JA, PRESCOTT LF.Clinical pharmacokinetics of paracetamol[J].Clin Pharmacokinet, 1982, 7 (2) :93-107.
    [27]LARSON AM.Acetaminophen hepatotoxicity[J].Clin Liver Dis, 2007, 11 (3) :525-548.
    [28]HODGMAN MJ, GARRARD AR.A review of acetaminophen poisoning[J].Crit Care Clin, 2012, 28 (4) :499-516.
    [29]BUNCHORNTAVAKUL C, REDDY KR.Acetaminophen-related hepatotoxicity[J].Clin Liver Dis, 2013, 17 (4) :593.
    [30]ROBERTS DW, LEE WM, HINSON JA, et al.An immunoassay to rapidly measure acetaminophen protein adducts accurately identifies patients with acute liver injury or failure[J].Clin Gastroenterol Hepatol, 2017, 15 (4) :555-562.e3.
    [31]O'GRADY J.Timing and benefit of liver transplantation in acute liver failure[J].J Hepatol, 2013, 60 (3) :663-670.
    [32]HUO T, WU JC, SHENG WY, et al.Prognostic factor analysis of fulminant and subfulminant hepatic failure in an area endemic for hepatitis B[J].J Gastroenterol Hepatol, 1996, 11 (6) :560-565.
    [33]KAMATH PS, WIESNER RH, MALINCHOC M, et al.A model to predict survival in patients with end-stage liver disease[J].Hepatology, 2001, 33 (2) :464-470.
    [34]MALINCHOC M, KAMATH PS, GORDON FD, et al.A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts[J].Hepatology, 2000, 31 (4) :864-871.
    [35]MARTIN EF, O’BRIEN C.Update on MELD and organ allocation[J].Clin Liver Dis, 2015, 5 (4) :105-107.
    [36]CHRISTENSEN E.Prognostic models including the Child Pugh, MELDand Mayo risk scores:Where are we and where should we go?[J].JHepatol, 2004, 41 (2) :344-350.
    [37]KARKHANIS J, VERNA EC, CHANG MS, et al.Steroid use in acute liver failure[J].Hepatology, 2014, 59 (2) :612-621.
    [38]ZHAO B, ZHANG HY, XIE GJ, et al.Evaluation of the efficacy of steroid therapy on acute liver failure[J].Exp Ther Med, 2016, 12 (5) :3121-3129.
    [39]ZHANG HY, ZHANG XQ.Predictive model for the efficacy of glucocorticoids in treating acute-on-chronic preliver failure and roadmap[J].Chin J Gastroenterol Hepatol, 2016, 25 (5) :495-498. (in Chinese) 张辉艳, 张绪清.糖皮质激素治疗慢加ALF前期的疗效预测模型与路线图[J].胃肠病学和肝病学杂志, 2016, 25 (5) :495-498.
    [40]GAO L, SHI XF.Research advances in the antiviral therapy for hepatitis B-related acute-on-chronic liver failure[J].Chongqing Med, 2016, 45 (7) :980-982. (in Chinese) 高莉, 石小枫.乙型肝炎相关慢加ALF抗病毒治疗的研究进展[J].重庆医学, 2016, 45 (7) :980-982.
    [41]SALIBA F, CAMUS C, DURAND F, et al.Albumin dialysis with a noncell artificial liver support device in patients with acute liver failure:A randomized, controlled trial[J].Ann Intern Med, 2013, 159 (8) :522-531.
    [42]BERNUAU J.High volume plasma exchange in patients with acute liver failure[J].J Hepatol, 2016, 65 (3) :646-647.
    [43]LARSEN FS, SCHMIDT LE, BERNSMEIER C, et al.High-volume plasma exchange in patients with acute liver failure:An open randomised controlled trial[J].J Hepatol, 2016, 64 (1) :69-78.
    [44]DHAWAN A, STROM SC, SOKAL E, et al.Human hepatocyte transplantation[J].Methods Mol Biol, 2010, 640:525-534.
    [45]DHAWAN A, PUPPI J, HUGHES RD, et al.Human hepatocyte transplantation:Current experience and future challenges[J].Nat Rev Gastroenterol Hepatol, 2010, 7 (5) :288-298.
    [46] BERNAL W, HYYRYLAINEN A, GERA A, et al.Lessons from look-back in acute liver failure?A single centre experience of 3300 patients[J].J Hepatol, 2013, 59 (1) :74-80.
    [47]GERMANI G, THEOCHARIDOU E, ADAM R, et al.Liver transplantation for acute liver failure in Europe:Outcomes over 20 years from the ELTR database[J].J Hepatol, 2012, 57 (2) :288-296.
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