中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 12
Dec.  2018
Turn off MathJax
Article Contents

Heterogeneity and homogeneity of nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2018.12.001
  • Published Date: 2018-12-20
  • Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent liver disease in China and the world. However, heterogeneity exists in the pathogenesis, pathology, and clinical phenotype of NAFLD. Metabolism/obesity and gene polymorphisms are involved in the pathogenesis of NAFLD. As for pathology, NAFLD in adults manifests as atypical fibrosis and sinus fibrosis, while NAFLD in children manifests as fibrosis in the portal area and lobular fibrosis in early stage. As for clinical phenotype, some patients may have diabetes or obesity. Such heterogeneity suggests that there are different strategies and methods for clinical diagnosis, treatment, and outcome evaluation.

     

  • loading
  • [1] ROMEO S, KOZLITINA J, XING C, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease[J]. Nat Genet, 2008, 40 (12) :1461-1465.
    [2] VICTOR RG, HALEY RW, WILLETT DL, et al, Dallas Heart Study Investigators. The Dallas Heart Study:A population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular health[J]. Am J Cardiol, 2004, 93 (12) :1473-1480.
    [3] SPELIOTES EK. Thwart your destiny; effect of nonacoholic fatty liver disease genes on steatosis, liver injury and cirrhosis varies by body mass index[J]. Hepatology, 2018, 68 (1) :372-374.
    [4] YKI-JRVINEN H, LUUKKONEN PK. Heterogeneity of non-alcoholic fatty liver disease[J]. Liver Int, 2015, 35 (12) :2498-2500.
    [5] SKOIEN R, RICHARDSON MM, JONSSON JR, et al. Heterogeneity of fibrosis patterns in non-alcoholic fatty liver disease supports the presence of multiple fibrogenic pathways[J]. Liver Int, 2013, 33 (4) :624-632.
    [6] LIU F, ZHAO JM, RAO HY, et al. Second harmonic generation reveals subtle fibrosis differences in adult and pediatric nonalcoholic fatty liver disease[J]. Am J Clin Pathol, 2017, 148 (6) :502-512.
    [7] YOUNOSSI Z, HENRY L. Contribution of alcoholic and nonalcoholic fatty liver disease to the burden of liver-related morbidity and mortality[J]. Gastroenterology, 2016, 150:1778-1785.
    [8] KOEHLER EM, PLOMPEN EP, SCHOUTEN JN, et al. Presence of diabetes mellitus and steatosis is associated with liver stiffness in a general population:The Rotterdam study[J]. Hepatology, 2016, 63 (1) :138-147.
    [9] KWOK R, CHOI KC, WONG GL, et al. Screening diabetic patients for non-alcoholic fatty liver disease with controlled attenuation parameter and liver stiffness measurements:A prospective cohort study[J].Gut, 2016, 65 (8) :1359-1368.
    [10] SOOKOIAN S, PIROLA CJ. Systematic review with meta-analysis:The significance of histological disease severity in lean patients with nonalcoholic fatty liver disease[J]. Aliment Pharmacol Ther, 2018, 47 (1) :16-25.
    [11] KUMAR R, MOHAN S. Non-alcoholic fatty liver disease in lean subjects:Characteristics and implications[J]. J Clin Transl Hepatol, 2017, 5 (3) :216-223.
    [12] European Association for the Study of the Liver (EASL) ; European Association for the Study of Diabetes (EASD) ; European Association for the Study of Obesity (EASO) . EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease[J]. J Hepatol, 2016, 64 (6) :1388-1402.
    [13] VAJRO P, LENTA S, SOCHA P, et al. Diagnosis of nonalcoholic fatty liver disease in children and adolescents:Position paper of the ESPGHAN Hepatology Committee[J]. J Pediatr Gastroenterol Nutr, 2012, 54 (5) :700-713.
    [14] VOS MB, ABRAMS SH, BARLOW SE, et al. NASPGHAN clinical practice guideline for the diagnosis and treatment of nonalcoholic fatty liver disease in children:Recommendations from the Expert Committee on NAFLD (ECON) and the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) [J]. J Pediatr Gastroenterol Nutr, 2017, 64 (2) :319-334.
    [15] JAYAKUMAR S, MIDDLETON MS, LAWITZ EJ, et al. Longitudinal correlations between MRE, MRI-PDFF, and liver histology in patients with non-alcoholic steatohepatitis:Analysis of data from a phase II trial of selonsertib[J]. J Hepatol, 2018.[Epub ahead of print]
    [16] WILDMAN-TOBRINER B, MIDDLETON MM, MOYLAN CA, et al.Association between magnetic resonance imaging-proton density fat fraction and liver histology features in patients with nonalcoholic fatty liver disease or nonalcoholic steatohepatitis[J]. Gastroenterology, 2018, 155 (5) :1428-1435.
    [17] HSU C, CAUSSY C, IMAJO K, et al. Magnetic resonance vs transient elastography analysis of patients with nonalcoholic fatty liver disease:A systematic review and pooled analysis of individual participants[J]. Clin Gastroenterol Hepatol, 2018.[Epub ahead of print]
    [18] ROMERO-GMEZ M, ZELBER-SAGI S, TRENELL M. Treatment of NAFLD with diet, physical activity and exercise[J]. J Hepatol, 2017, 67 (4) :829-846.
    [19] KONERMAN MA, JONES JC, HARRISON SA. Pharmacotherapy for NASH:Current and emerging[J]. J Hepatol, 2018, 68 (2) :362-375.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1361) PDF downloads(467) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return