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Volume 35 Issue 5
May  2019
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Article Navigation >  Journal of Clinical Hepatology  > 2019  >  35(5): 1057-1060

Effect of silibinin on liver aminotransferases in patients with nonalcoholic fatty liver disease: A meta-analysis

DOI: 10.3969/j.issn.1001-5256.2019.05.024

  • Department of Hepatopancreatobiliary and Splenic Medicine, Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces

Research funding:

 

  • Received Date: 2018-11-26
  • Published Date: 2019-05-20
    Abstract
  • Objective To conduct a meta-analysis of the articles on the effect of silibinin on aminotransferases in patients with nonalcoholic fatty liver disease ( NAFLD) , and to investigate the liver-protecting effect of silibinin in patients with NAFLD. Methods CNKI, Wanfang Data, VIP, SinoMed, PubMed, MEDLINE, Embase, and ScienceDirect were searched for randomized controlled trials ( RCTs) on the treatment of NAFLD patients with silibinin, The articles were screened according to inclusion and exclusion criteria, and then quality assessment and data extraction were performed. RevMan 5. 3 was used to perform the meta-analysis. Results A total of 8 articles with 665 patients were included. After 8 weeks to 3 months of silibinin treatment, there were significant reductions in the serum levels of alanine aminotransferase ( ALT) ( weighted mean difference [WMD]=-11. 60, 95% confidence interval [CI]:-18. 68 to-4. 51, P = 0. 001) and aspartate aminotransferase ( AST) ( WMD =-11. 56, 95% CI:-16. 93 to-6. 18, P < 0. 001) . Conclusion Silibinin can significantly reduce the serum levels of ALT and AST in patients with NAFLD.

     

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