Tumor necrosis factor-alpha-induced protein 8-like 2( TIPE2) can negatively regulate innate immunity and adaptive immunity and participate in the development and progression of various liver diseases,such as hepatitis,liver cirrhosis,and hepatocellular carcinoma,by affecting a variety of signaling pathways. This article summarizes the current research on the involvement of TIPE2 in the pathogenesis of different liver diseases and points out that TIPE2 may become a new target for the treatment of liver diseases.
[1] SUN H,GONG S,CARMODY RJ,et al. TIPE2,a negative regulator of innate and adaptive immunity that maintains immune homeostasis[J]. Cell,2008,133(3):415-426.
|
[2] ZHANG X,WANG J,FAN C,et al. Crystal structure of TIPE2provides insights into immune homeostasis[J]. Nat Struct Mol Biol,2009,16(1):89-90.
|
[3] YANG PL,ALTHAGE A,CHUNG J,et al. Immune effectors required for hepatitis B virus clearance[J]. Proc Natl Acad Sci U S A,2010,107(2):798-802.
|
[4] PHILLIPS S,CHOKSHI S,RIVA A,et al. CD8(+)T cell control of hepatitis B virus replication:Direct comparison between cytolytic and noncytolytic functions[J]. J Immunol,2010,184(1):287-295.
|
[5] XI W,HU Y,LIU Y,et al. Roles of TIPE2 in hepatitis B virusinduced hepatic inflammation in humans and mice[J]. Mol Immunol,2011,48(9-10):1203-1208.
|
[6] ZHANG W,ZHANG J,ZHAO L,et al. TIPE2 protein negatively regulates HBV-specific CD8+T lymphocyte functions in humans[J]. Mol Immunol,2015,64(1):204-209.
|
[7] JIANG LN,ZHANG H,ZHAI JY,et al. TIPE2 and its role in inflammatory diseases[J]. Chin J Immunol,2019,35(19):2410-2413,2418.(in Chinese)蒋丽娜,张红,翟嘉怡,等.TIPE2及其在炎症相关疾病中的作用[J].中国免疫学杂志,2019,35(19):2410-2413,2418.
|
[8] FAN Y,ZHANG Y,WANG N,et al. Tumor necrosis factor-α-induced protein 8-like 2(TIPE2)is associated with immune phases of patients with chronic hepatitis B[J]. Oncotarget,2017,8(19):30781-30792.
|
[9] JI J,ZHANG YY,FAN YC. TIPE2 as a potential therapeutic target in chronic viral hepatitis[J]. Expert Opin Ther Targets,2019,23(6):485-493.
|
[10] WANG LY,FAN YC,ZHAO J,et al. Elevated expression of tumour necrosis factor-α-induced protein 8(TNFAIP8)-like 2 mRNA in peripheral blood mononuclear cells is associated with disease progression of acute-on-chronic hepatitis B liver failure[J]. J Viral Hepat,2014,21(1):64-73.
|
[11] FAN YC,WANG N,SUN YY,et al. TIPE2 mRNA level in PBMCs serves as a novel biomarker for predicting short-term mortality of acute-on-chronic hepatitis B liver failure:A prospective single-center study[J]. Medicine(Baltimore),2015,94(39):e1638.
|
[12] LIN MV,KING LY,CHUNG RT. Hepatitis C virus-associated cancer[J]. Annu Rev Pathol,2015,10:345-370.
|
[13] KONG L,LIU K,ZHANG YZ,et al. Downregulation of TIPE2mRNA expression in peripheral blood mononuclear cells from patients with chronic hepatitis C[J]. Hepatol Int,2013,7(3):844-849.
|
[14] MELLOR AL,BABAB B,CHANDLER PR,et al. Cutting edge:CpG oligonucleotides induce splenic CD19+dendritic cells to acquire potent indoleamine 2,3-dioxygenase-dependent T cell regulatory functions via IFN Type 1 signaling[J]. J Immunol,2005,175(9):5601-5605.
|
[15] LUAN YY,YAO YM,ZHANG L,et al. Expression of tumor necrosis factor-αinduced protein 8 like-2 contributes to the immunosuppressive property of CD4(+)CD25(+)regulatory T cells in mice[J]. Mol Immunol,2011,49(1-2):219-226.
|
[16] KONG L,JIN M,WANG WZ,et al. The mRNA expression of TIPE2,Foxp3,and CTLA-4 in peripheral blood mononucleated cells in patients with chronic hepatitis C and their clinical significance[J]. J Clin Hepatol,2019,35(2):323-327.(in Chinese)孔丽,金萌,王卫真,等.TIPE2、Foxp3、CTLA-4 mRNA在慢性丙型肝炎患者外周血单个核细胞中的表达及临床意义[J].临床肝胆病杂志,2019,35(2):323-327.
|
[17] YAO RQ,MA B. The potential role and significance of tumor necrosis factor-αinduced protein 8 like-2 in autoimmune diseases[J]. Med J Chin PLA,2017,42(8):749-752.(in Chinese)姚人骐,马兵.肿瘤坏死因子-α诱导蛋白-8样分子-2在自身免疫疾病中的作用及意义[J].解放军医学杂志,2017,42(8):749-752.
|
[18] FREUNDT EC,BIDERE N,LENARDO MJ. A different TIPE of immune homeostasis[J]. Cell,2008,133(3):401-402.
|
[19] LOU Y,LIU S. The TIPE(TNFAIP8)family in inflammation,immunity,and cancer[J]. Mol Immunol,2011,49(1-2):4-7.
|
[20] LIU RL,RUAN QG. Advances of negative immune regulator TIPE2 in the pathogenesis of autoimmune diseases[J]. Int J Immunol,2016,39(4):368-372.(in Chinese)刘芮伶,阮庆国.免疫负调控因子TIPE2在自身免疫性疾病发病过程中的作用及机制研究进展[J].国际免疫学杂志,2016,39(4):368-372.
|
[21] LI D,TAN Y. TIPE2 suppresses atherosclerosis by exerting a protective effect on macrophages via the inhibition of the Akt signaling pathway[J]. Exp Ther Med,2019,17(4):2937-2944.
|
[22] QIAN J,MENG Z,GUAN J,et al. Expression and roles of TIPE2 in autoimmune hepatitis[J]. Exp Ther Med,2017,13(3):942-946.
|
[23] QIN B,WEI T,WANG L,et al. Decreased expression of TIPE2 contributes to the hyperreactivity of monocyte to Tolllike receptor ligands in primary biliary cirrhosis[J]. J Gastroenterol Hepatol,2016,31(6):1177-1183.
|
[24] CAI SP,CHENG XY,CHEN PJ,et al. Transmembrane protein88 attenuates liver fibrosis by promoting apoptosis and reversion of activated hepatic stellate cells[J]. Mol Immunol,2016,80:58-67.
|
[25] THOMPSON MD,MONGA SP. WNT/beta-catenin signaling in liver health and disease[J]. Hepatology,2007,45(5):1298-1305.
|
[26] CHENG JH,SHE H,HAN YP,et al. Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis[J]. Am J Physiol Gastrointest Liver Physiol,2008,294(1):g39-g49.
|
[27] TOKUNAGA Y,OSAWA Y,OHTSUKI T,et al. Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model[J]. Sci Rep,2017,7(1):325.
|
[28] TUO H,WANG Y,WANG L,et al. MiR-324-3p promotes tumor growth through targeting DACT1 and activation of Wnt/β-catenin pathway in hepatocellular carcinoma[J]. Oncotarget,2017,8(39):65687-65698.
|
[29] XU DD,LI XF,LI YH,et al. TIPE2 attenuates liver fibrosis by reversing the activated hepatic stellate cells[J]. Biochem Biophys Res Commun,2018,498(1):199-206.
|
[30] CAO X,ZHANG L,SHI Y,et al. Human tumor necrosis factor(TNF)-alpha-induced protein 8-like 2 suppresses hepatocellular carcinoma metastasis through inhibiting Rac1[J]. Mol Cancer,2013,12(1):149.
|
[31] ZHANG YH,YAN HQ,WANG F,et al. TIPE2 inhibits TNF-α-induced hepatocellular carcinoma cell metastasis via Erk1/2downregulation and NF-κB activation[J]. Int J Oncol,2015,46(1):254-264.
|
[32] WANG Y,JIANG Y,ZHOU J,et al. Hepatitis C virus promotes hepatocellular carcinogenesis by targeting TIPE2, a new regulator of DNA damage response[J]. Tumour Biol,2016,37(11):15265-15274.
|
[33] WANG L,CHEN C,FENG S,et al. TIPE-2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3-kinase/AKT signaling pathway[J]. Mol Med Rep,2018,17(5):7017-7026.
|