[1] HAN Q,ZHAO H,JIANG Y,et al. HCC-derived exosomes:Critical player and target for cancer immune escape[J].Cells,2019,8(6):558.
|
[2] WU Z,ZENG Q,CAO K,et al. Exosomes:Small vesicles with big roles in hepatocellular carcinoma[J]. Oncotarget,2016,7(37):60687-60697.
|
[3] MORIS D,BEAL EW,CHAKEDIS J,et al. Role of exosomes in treatment of hepatocellular carcinoma[J]. Surg Oncol,2017,26(3):219-228.
|
[4] ZHOU S,ABDOUH M,ARENA V,et al. Reprogramming malignant cancer cells toward a benign phenotype following exposure to human embryonic stem cell microenvironment[J].PLo S One,2017,12(1):e0169899.
|
[5] THAKUR BK,ZHANG H,BECKER A,et al. Double-stranded DNA in exosomes:A novel biomarker in cancer detection[J].Cell Res,2014,24(6):766-769.
|
[6] SALEEM SN,ABDEL-MAGEED AB. Tumor-derived exosomes in oncogenic reprogramming and cancer progression[J]. Cell Mol Life Sci,2015,72(1):1-10.
|
[7] WEI JX,LV LH,WAN YL,et al. Vps4A functions as a tumor suppressor by regulating the secretion and uptake of exosomal microRNAs in human hepatoma cells[J]. Hepatology,2015,61(4):1284-1294.
|
[8] CHEN L,GUO P,HE Y,et al. HCC-derived exosomes elicit HCC progression and recurrence by epithelial-mesenchymal transition through MAPK/ERK signalling pathway[J]. Cell Death Dis,2018,9(5):513.
|
[9] SZABO G,MOMEN-HERAVI F. Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets[J]. Nat Rev Gastro Hepat,2017,14(8):455-466.
|
[10] SAHA B,MOMEN-HERAVI F,FURI I,et al. Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation through heat shock protein 90[J]. Hepatology,2018,67(5):1986-2000.
|
[11] JUAN T,FRTHAUER M. Biogenesis and function of ESCRTdependent extracellular vesicles[J]. Semin Cel Dev Biol,2018,74:66-77.
|
[12] FAROOQI AA,DESAI NN,QURESHI MZ,et al. Exosome biogenesis,bioactivities and functions as new delivery systems of natural compounds[J]. Biotechnol Adv,2018,36(1):328-334.
|
[13] QU Z,FENG J,PAN H,et al. Exosomes derived from HCC cells with different invasion characteristics mediated EMT through TGF-β/Smad signaling pathway[J]. Onco Targets Ther,2019,12:6897-6905.
|
[14] LIU C,YANG Y,WU Y. Recent advances in exosomal protein detection via liquid biopsy biosensors for cancer screening,diagnosis,and prognosis[J]. AAPS J,2018,20(2):41.
|
[15] SHAO Z,PAN Q,ZHANG Y. Hepatocellular carcinoma cellderived extracellular vesicles encapsulated microRNA-584-5p facilitates angiogenesis through PCK1-mediated nuclear factor E2-related factor 2 signaling pathway[J]. Int J Biochem Cell Biol,2020:105789.
|
[16] LU Y,NI F,XU M,et al. Alcohol promotes mammary tumor growth through activation of VEGF-dependent tumor angiogenesis[J]. Oncol Lett,2014,8(2):673-678.
|
[17] LAMICHHANE TN,LEUNG CA,DOUTI LY,et al. Ethanol induces enhanced vascularization bioactivity of endothelial cellderived extracellular vesicles via regulation of microRNAs and long non-coding RNAs[J]. Sci Rep,2017,7(1):13794.
|
[18] CAO LQ,YANG XW,CHEN YB,et al. Exosomal miR-21 regulates the TETs/PTENp1/PTEN pathway to promote hepatocellular carcinoma growth[J]. Mol Cancer,2019,18(1):148.
|
[19] CHO HJ,EUN JW,BAEK GO,et al. Serum exosomal microRNA,miR-10b-5p,as a potential diagnostic biomarker for early-stage hepatocellular carcinoma[J]. J Clin Med,2020,9(1):112-115.
|
[20] LIU W,HU J,ZHOU K,et al. Serum exosomal miR-125b is a novel prognostic marker for hepatocellular carcinoma[J].Onco Targets Ther,2017,10:3843-3851.
|
[21] SRUTHI TV,EDATT L,RAJI GR,et al. Horizontal transfer of miR-23a from hypoxic tumor cell colonies can induce angiogenesis[J]. J Cell Physiol,2018,233(4):3498-3514.
|
[22] SUGIMACHI K,MATSUMURA T,HIRATA H,et al. Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation[J]. Br J Cancer,2015,112(3):532-538.
|
[23] KOGURE T,LIN WL,YAN IK,et al. Intercellular nanovesiclemediated microRNA transfer:A mechanism of environmental modulation of hepatocellular cancer cell growth[J]. Hepatology,2011,54(4):1237-1248.
|
[24] LI L,TANG J,ZHANG B,et al. Epigenetic modification of MiR-429 promotes liver tumour-initiating cell properties by targeting Rb binding protein 4[J]. Gut,2015,64(1):156-167.
|
[25] SOHN W,KIM J,KANG SH,et al. Serum exosomal microRNAs as novel biomarkers for hepatocellular carcinoma[J].Exp Mol Med,2015,47:e184.
|
[26] WANG H,LU Z,ZHAO X. Tumorigenesis,diagnosis,and therapeutic potential of exosomes in liver cancer[J]. J Hematol Oncol,2019,12(1):133.
|
[27] WANG S,XU M,LI X,et al. Exosomes released by hepatocarcinoma cells endow adipocytes with tumor-promoting properties[J]. J Hematol Oncol,2018,11(1):82.
|
[28] YIN C,HAN Q,XU D,et al. SALL4-mediated upregulation of exosomal miR-146a-5p drives T-cell exhaustion by M2tumor-associated macrophages in HCC[J]. Oncoimmunology,2019,8(7):1601479.
|
[29] FU Q,ZHANG Q,LOU Y,et al. Primary tumor-derived exosomes facilitate metastasis by regulating adhesion of circulating tumor cells via SMAD3 in liver cancer[J]. Oncogene,2018,37(47):6105-6118.
|
[30] WU Q,ZHOU L,LV D,et al. Exosome-mediated communication in the tumor microenvironment contributes to hepatocellular carcinoma development and progression[J]. J Hematol Oncol,2019,12(1):53.
|
[31] WU DM,DENG SH,LIU T,et al. TGF-β-mediated exosomal lnc-MMP2-2 regulates migration and invasion of lung cancer cells to the vasculature by promoting MMP2 expression[J]. Cancer Med,2018,7(10):5118-5129.
|
[32] LOU G,SONG X,YANG F,et al. Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma[J]. J Hematol Oncol,2015,8:122.
|
[33] LIU J,FAN L,YU H,et al. Endoplasmic reticulum stress causes liver cancer cells to release exosomal miR-23a-3p and up-regulate programmed death ligand 1 expression in macrophages[J]. Hepatology,2019,70(1):241-258.
|
[34] QU Z,JIANG C,WU J,et al. Exosomes as potent regulators of HCC malignancy and potential bio-tools in clinical application[J]. Int J Clin Exp Med,2015,8(10):17088-17095.
|
[35] PAN JH,ZHOU H,ZHAO XX,et al. Role of exosomes and exosomal microRNAs in hepatocellular carcinoma:Potential in diagnosis and antitumour treatments(Review)[J]. Int J Mol Med,2018,41(4):1809-1816.
|
[36] LU Z,ZUO B,JING R,et al. Dendritic cell-derived exosomes elicit tumor regression in autochthonous hepatocellular carcinoma mouse models[J]. J Hepatol,2017,67(4):739-748.
|
[37] MULLER L,SIMMS P,HONG CS,et al. Human tumor-derived exosomes(tex)regulate treg functions via cell surface signaling rather than uptake mechanisms[J]. Oncoimmunology,2017,6(8):e1261243.
|
[38] LI X,LEI Y,WU M,et al. Regulation of macrophage activation and polarization by HCC-derived exosomal lncRNA TUC339[J]. Int J Mol Sci,2018,19(10):2958.
|
[39] LI Z,JIANG P,LI J,et al. Tumor-derived exosomal lncSox2ot promotes EMT and stemness by acting as a ceRNA in pancreatic ductal adenocarcinoma[J]. Oncogene,2018,37(28):3822-3838.
|
[40] BRUNETTI O,GNONI A,LICCHETTA A,et al. Predictive and prognostic factors in HCC patients treated with Sorafenib[J].Medicina(Kaunas),2019,55(10):e707.
|
[41] LI LM,LIU ZX,CHENG QY. Exosome plays an important role in the development of hepatocellular carcinoma[J]. Pathol Res Pract,2019,215(8):152468.
|
[42] SAFAEI R,LARSON BJ,CHENG TC,et al. Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells[J]. Mol Cancer Ther,2005,4(10):1595-1604.
|
[43] LIU J,XU R,MAI SJ,et al. LncRNA CSMD1-1 promotes the progression of Hepatocellular carcinoma by activating MYC signaling[J]. Theranostics,2020,10(17):7527-7544.
|
[44] QU Z,WU J,WU J,et al. Exosomes derived from HCC cells induce sorafenib resistance in hepatocellular carcinoma both in vivo and in vitro[J]. J Exp Clin Cancer Res,2016,35(1):159.
|
[45] TAKAHASHI K,YAN IK,KOGURE T,et al. Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer[J].FEBS Open Bio,2014,4:458-467.
|
[46] GONZALEZ-KING H,GARCA NA,ONTORIA-OVIEDO I,et al. Hypoxia inducible factor-1αpotentiates jagged 1-mediated angiogenesis by mesenchymal stem cell-derived exosomes[J]. Stem Cells,2017,35(7):1747-1759.
|
[47] YU Y,MIN Z,ZHIHANG Z,et al. Hypoxia-induced exosomes promote hepatocellular carcinoma proliferation and metastasis via miR-1273f transfer[J]. Exp Cell Res,2019,385(1):111649.
|
[48] ZHOU L,LV T,ZHANG Q,et al. The biology,function and clinical implications of exosomes in lung cancer[J]. Cancer Lett,2017,407:84-92.
|
[49] ZHANG C,YANG X,QI Q,et al. lncRNA-HEIH in serum and exosomes as a potential biomarker in the HCV-related hepatocellular carcinoma[J]. Cancer Biomark,2018,21(3):651-659.
|
[50] QU Z,WU J,WU J,et al. Exosomal miR-665 as a novel minimal y invasive biomarker for hepatocellular carcinoma diagnosis and prognosis[J]. Oncotarget,2017,8(46):80666-80678.
|
[51] FANG T,LV H,LV G,et al. Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer[J]. Nat Commun,2018,9(1):191.
|
[52] MORROW D,CULLEN JP,CAHILL PA,et al. Ethanol stimulates endothelial cell angiogenic activity via a Notch-and angiopoietin-1-dependent pathway[J]. Cardiovasc Res,2008,79(2):313-321.
|
[53] XU Y,LIU Y,LI Z,et al. Long non-coding RNA H19 is involved in sorafenib resistance in hepatocellular carcinoma by upregulating miR-675[J]. Oncol Rep,2020,44(1):165-173.
|
[54] ABDOUH M,HAMAM D,GAO ZH,et al. Exosomes isolated from cancer patients’sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells[J]. J Exp Clin Cancer Res,2017,36(1):113.
|
[55] ZHANG H,DENG T,LIU R,et al. Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis[J]. Nat Commun,2017,8:15016.
|
[56] ZHANG PF,GAO C,HUANG XY,et al. Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma[J]. Mol Cancer,2020,19(1):110.
|
[57] DENG H,KAN A,LYU N,et al. Dual vascular endothelial growth factor receptor and fibroblast growth factor receptor inhibition elicits antitumor immunity and enhances programmed cell death-1 checkpoint blockade in hepatocellular carcinoma[J]. Liver Cancer,2020,9(3):338-357.
|
[58] LU Z,ZUO B,JING R,et al. Dendritic cell-derived exosomes elicit tumor regression in autochthonous hepatocellular carcinoma mouse models[J]. J Hepatol,2017,67(4):739-748.
|
[59] HONGYUN Z,LIFENG Y,JOELLE B,et al. Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism[J]. e Life,2016,2:10250.
|
[60] UMEZU T,OHYASHIKI K,KURODA M,et al. Leukemia cell to endothelial cell communication via exosomal miRNAs[J]. Oncogene,2013,32(22):2747-2755.
|
[61] YU Z,ZHAO S,REN L,et al. Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation[J]. Oncotarget,2017,8(38):63461-63483.
|
[62] CHENG D,DENG J,ZHANG B,et al. LncRNA HOTAIR epigenetically suppresses miR-122 expression in hepatocellular carcinoma via DNA methylation[J]. EBio Medicine,2018,36(11):159-170.
|
[63] YUKAWA H,SUZUKI K,AOKI K,et al. Imaging of angiogenesis of human umbilical vein endothelial cells by uptake of exosomes secreted from hepatocellular carcinoma cells[J]. Sci Rep,2018,8(1):6765.
|