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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 1
Jan.  2021
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Article Contents

Research advances in the regulation of epithelial-mesenchymal transition and targeted therapy for liver fibrosis

DOI: 10.3969/j.issn.1001-5256.2021.01.035
  • Received Date: 2020-07-05
  • Accepted Date: 2020-08-03
  • Published Date: 2021-01-20
  • The pathological basis of liver fibrosis is the deposition of extracellular matrix (ECM), and myofibroblasts are the main source of ECM. Epithelial-mesenchymal transition (EMT) is one of production mechanisms of myofibroblasts. At present, a large number of studies have shown that intervention of key EMT molecules and signaling pathways as targets can reduce liver fibrosis. Based on literature review, this article summarizes the signaling pathways associated with EMT, important regulatory molecules, and drugs targeting EMT in the treatment of liver fibrosis, so as to provide new ideas for the treatment of liver fibrosis.

     

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