中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 1
Jan.  2021
Turn off MathJax
Article Contents

Effect of glucagon-like peptide-1 receptor agonist in treatment of nonalcoholic fatty liver disease and related mechanism

DOI: 10.3969/j.issn.1001-5256.2021.01.043
  • Received Date: 2020-06-19
  • Accepted Date: 2020-09-10
  • Published Date: 2021-01-20
  • The incidence rate of nonalcoholic fatty liver disease (NAFLD) continues to rise around the world, and due to its complex pathogenesis, there is still a lack of effective treatment drugs. If NAFLD is not treated in time, it may increase the risk of related metabolic diseases such as diabetes and hyperlipidemia and even lead to liver fibrosis and liver cirrhosis. Glucagon-like peptide-1 is a hormone secreted by L-shaped cells of the small intestine and can regulate glucose-dependent stimulation of insulin secretion, reduce gastric emptying, and inhibit food intake. This article reviews the effect of glucagon-like peptide-1 receptor agonist in the treatment of NAFLD and related mechanism.

     

  • loading
  • [1]
    ESLAM M, SANYAL AJ, GEORGE J, et al. MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease[J]. Gastroenterology, 2020, 158(7): 1999-2014. e1. DOI: 10.1053/j.gastro.2019.11.312
    [2]
    IQBAL U, PERUMPAIL BJ, AKHTAR D, et al. The epidemiology, risk profiling and diagnostic challenges of nonalcoholic fatty liver disease[J]. Medicines (Basel), 2019, 6(1): 41.
    [3]
    ATHYROS VG, POLYZOS SA, KOUNTOURAS J, et al. Non-alcoholic fatty liver disease treatment in patients with type 2 diabetes mellitus; new kids on the block[J]. Curr Vasc Pharmacol, 2020, 18(2): 172-181. DOI: 10.2174/1570161117666190405164313
    [4]
    YANG Z, FU BS. Research status of liver transplantation in the treatment of non-alcoholic fatty liver disease[J]. Ogran Transplantation, 2020, 11(3): 419-423. (in Chinese) DOI: 10.3969/j.issn.1674-7445.2020.03.017

    杨洲, 傅斌生. 肝移植治疗非酒精性脂肪性肝病的研究现状[J]. 器官移植, 2020, 11(3): 419-423. DOI: 10.3969/j.issn.1674-7445.2020.03.017
    [5]
    ZHOU F, ZHOU J, WANG W, et al. Unexpected rapid increase in the burden of NAFLD in China from 2008 to 2018: A systematic review and meta-analysis[J]. Hepatology, 2019, 70(4): 1119-1133. DOI: 10.1002/hep.30702
    [6]
    LIU Q, NIU CY. From "two hit theory" to "multiple hit theory": Implications of evolution of pathogenesis concepts for treatment of non-alcoholic fatty liver disease[J]. World Chin J Dig, 2019, 27(19): 1171-1178. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-XXHB201919001.htm

    刘勤, 牛春燕. 由"二次打击"到"多重打击":发病机制的演变带给非酒精性脂肪性肝病的治疗启示[J]. 世界华人消化杂志, 2019, 27(19): 1171-1178. https://www.cnki.com.cn/Article/CJFDTOTAL-XXHB201919001.htm
    [7]
    GAO X. New thoughts about renaming nonalcoholic fatty liver disease[J]. J Clin Hepatol, 2020, 36(6): 1201-1204. (in Chinese) DOI: 10.3969/j.issn.1001-5256.2020.06.001

    高鑫. 非酒精性脂肪性肝病更名带来的新思考[J]. 临床肝胆病杂志, 2020, 36(6): 1201-1204. DOI: 10.3969/j.issn.1001-5256.2020.06.001
    [8]
    ZHOU Q, SU J, JI MY. Progress in the treatment of nonalcoholic fatty liver disease[J]. China Med Herald, 2020, 17(6): 26-29. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY202006008.htm

    周谦, 苏娟, 季梦遥. 非酒精性脂肪性肝病的治疗研究进展[J]. 中国医药导报, 2020, 17(6): 26-29. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY202006008.htm
    [9]
    MVLLER TD, FINAN B, BLOOM SR, et al. Glucagon-like peptide 1 (GLP-1)[J]. Mol Metab, 2019, 30: 72-130. DOI: 10.1016/j.molmet.2019.09.010
    [10]
    BAGGIO LL, DRUCKER DJ. Biology of incretins: GLP-1 and GIP[J]. Gastroenterology, 2007, 132(6): 2131-2157. DOI: 10.1053/j.gastro.2007.03.054
    [11]
    BULLOCK BP, HELLER RS, HABENER JF. Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor[J]. Endocrinology, 1996, 137(7): 2968-2978. DOI: 10.1210/endo.137.7.8770921
    [12]
    RICHARDS P, PARKER HE, ADRIAENSSENS AE, et al. Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model[J]. Diabetes, 2014, 63(4): 1224-1233. DOI: 10.2337/db13-1440
    [13]
    CANTINI G, MANNUCCI E, LUCONI M. Perspectives in GLP-1 Research: New targets, new receptors[J]. Trends Endocrinol Metab, 2016, 27(6): 427-438. DOI: 10.1016/j.tem.2016.03.017
    [14]
    XIAO C, BANDSMA RH, DASH S, et al. Exenatide, a glucagon-like peptide-1 receptor agonist, acutely inhibits intestinal lipoprotein production in healthy humans[J]. Arterioscler Thromb Vasc Biol, 2012, 32(6): 1513-1519. DOI: 10.1161/ATVBAHA.112.246207
    [15]
    HSIEH J, LONGUET C, BAKER CL, et al. The glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice[J]. Diabetologia, 2010, 53(3): 552-561. DOI: 10.1007/s00125-009-1611-5
    [16]
    SHARMA D, VERMA S, VAIDYA S, et al. Recent updates on GLP-1 agonists: Current advancements & challenges[J]. Biomed Pharmacother, 2018, 108: 952-962. DOI: 10.1016/j.biopha.2018.08.088
    [17]
    KHOO J, HSIANG J, TANEJA R, et al. Comparative effects of liraglutide 3 mg vs structured lifestyle modification on body weight, liver fat and liver function in obese patients with non-alcoholic fatty liver disease: A pilot randomized trial[J]. Diabetes Obes Metab, 2017, 19(12): 1814-1817. DOI: 10.1111/dom.13007
    [18]
    ARMSTRONG MJ, HULL D, GUO K, et al. Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis[J]. J Hepatol, 2016, 64(2): 399-408. DOI: 10.1016/j.jhep.2015.08.038
    [19]
    PETIT JM, CERCUEIL JP, LOFFROY R, et al. Effect of liraglutide therapy on liver fat content in patients with inadequately controlled type 2 diabetes: the lira-NAFLD study[J]. J Clin Endocrinol Metab, 2017, 102(2): 407-415. http://smartsearch.nstl.gov.cn/paper_detail.html?id=19d6760c2234e3c8576ae4a3f8dbe431
    [20]
    SHAO N, KUANG HY, HAO M, et al. Benefits of exenatide on obesity and non-alcoholic fatty liver disease with elevated liver enzymes in patients with type 2 diabetes[J]. Diabetes Metab Res Rev, 2014, 30(6): 521-529. DOI: 10.1002/dmrr.2561
    [21]
    ARMSTRONG MJ, GAUNT P, AITHAL GP, et al. Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): A multicentre, double-blind, randomised, placebo-controlled phase 2 study[J]. Lancet, 2016, 387(10019): 679-690. DOI: 10.1016/S0140-6736(15)00803-X
    [22]
    EGUCHI Y, KITAJIMA Y, HYOGO H, et al. Pilot study of liraglutide effects in non-alcoholic steatohepatitis and non-alcoholic fatty liver disease with glucose intolerance in Japanese patients (LEAN-J)[J]. Hepatol Res, 2015, 45(3): 269-278. DOI: 10.1111/hepr.12351
    [23]
    SEKO Y, SUMIDA Y, TANAKA S, et al. Effect of 12-week dulaglutide therapy in Japanese patients with biopsy-proven non-alcoholic fatty liver disease and type 2 diabetes mellitus[J]. Hepatol Res, 2017, 47(11): 1206-1211. DOI: 10.1111/hepr.12837
    [24]
    RAHMAN K, LIU Y, KUMAR P, et al. C/EBP homologous protein modulates liraglutide-mediated attenuation of non-alcoholic steatohepatitis[J]. Lab Invest, 2016, 96(8): 895-908. DOI: 10.1038/labinvest.2016.61
    [25]
    LAKOSKI SG, LAGACE TA, COHEN JC, et al. Genetic and metabolic determinants of plasma PCSK9 levels[J]. J Clin Endocrinol Metab, 2009, 94(7): 2537-2543. DOI: 10.1210/jc.2009-0141
    [26]
    YANG SH, LI S, ZHANG Y, et al. Positive correlation of plasma PCSK9 levels with HbA1c in patients with type 2 diabetes[J]. Diabetes Metab Res Rev, 2016, 32(2): 193-199. DOI: 10.1002/dmrr.2712
    [27]
    DONG B, SINGH AB, AZHAR S, et al. High-fructose feeding promotes accelerated degradation of hepatic LDL receptor and hypercholesterolemia in hamsters via elevated circulating PCSK9 levels[J]. Atherosclerosis, 2015, 239(2): 364-374. DOI: 10.1016/j.atherosclerosis.2015.01.013
    [28]
    YANG SH, XU RX, CUI CJ, et al. Liraglutide downregulates hepatic LDL receptor and PCSK9 expression in HepG2 cells and db/db mice through a HNF-1a dependent mechanism[J]. Cardiovasc Diabetol, 2018, 17(1): 48. DOI: 10.1186/s12933-018-0689-9
    [29]
    FANG QH, SHEN QL, LI JJ, et al. Inhibition of microRNA-124a attenuates non-alcoholic fatty liver disease through upregulation of adipose triglyceride lipase and the effect of liraglutide intervention[J]. Hepatol Res, 2019, 49(7): 743-757. http://www.ncbi.nlm.nih.gov/pubmed/30861258
    [30]
    CHIKKA MR, MCCABE DD, TYRA HM, et al. C/EBP homologous protein (CHOP) contributes to suppression of metabolic genes during endoplasmic reticulum stress in the liver[J]. J Biol Chem, 2013, 288(6): 4405-4415. DOI: 10.1074/jbc.M112.432344
    [31]
    SZEGEZDI E, LOGUE SE, GORMAN AM, et al. Mediators of endoplasmic reticulum stress-induced apoptosis[J]. EMBO Rep, 2006, 7(9): 880-885. DOI: 10.1038/sj.embor.7400779
    [32]
    RUTKOWSKI DT, WU J, BACK SH, et al. UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators[J]. Dev Cell, 2008, 15(6): 829-840. DOI: 10.1016/j.devcel.2008.10.015
    [33]
    YU X, HAO M, LIU Y, et al. Liraglutide ameliorates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome and pyroptosis activation via mitophagy[J]. Eur J Pharmacol, 2019, 864: 172715. DOI: 10.1016/j.ejphar.2019.172715
    [34]
    SATHYANARAYAN A, MASHEK MT, MASHEK DG. ATGL promotes autophagy/lipophagy via SIRT1 to control hepatic lipid droplet catabolism[J]. Cell Rep, 2017, 19(1): 1-9. http://www.ncbi.nlm.nih.gov/pubmed/28380348/
    [35]
    SAAD ZA, KHODEER DM, ZAITONE SA, et al. Exenatide ameliorates experimental non-alcoholic fatty liver in rats via suppression of toll-like receptor 4/NFκB signaling: Comparison to metformin[J]. Life Sci, 2020, 253: 117725. DOI: 10.1016/j.lfs.2020.117725
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)

    Article Metrics

    Article views (816) PDF downloads(42) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return